Myogenesis
- Distinct roles and requirements for Ras pathway signaling in visceral versus somatic muscle founder specification
Summary: A fundamentally different mechanism is demonstrated for how Ras signaling governs cell fate specification in the Drosophila somatic versus visceral mesoderms, providing insight into how signaling specificity is achieved.
- Myocardin-related transcription factors are required for skeletal muscle development
Summary: MRTFs are regulators of actin cycling and cytoskeletal gene expression. Loss of MRTFs in the mouse skeletal muscle causes muscle hypoplasia due to defects in sarcomere formation.
- Noncanonical roles for Tropomyosin during myogenesis
Summary: During myogenesis in Drosophila embryos, Tropomyosin, previously known to regulate muscle contraction, promotes myotube elongation, myoblast fusion and sarcomeric gene expression.
- HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo
Highlighted article: Hypoxia inducible factor 1α is dispensable for embryonic myogenesis but, via the inhibition of canonical Wnt signaling, negatively regulates muscle regeneration in adult mice.
- Intrinsic and extrinsic mechanisms regulating satellite cell function
Summary: This Review discusses how satellite stem cell behaviour is regulated during regeneration and degeneration by a complex balance between extrinsic cues and intrinsic regulatory mechanisms.