- Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate
Summary: SHH signaling within both the neural crest and endoderm influences thymus and parathyroid cell fate establishment and subsequent organogenesis.
- Ror2 signaling is required for local upregulation of GDF6 and activation of BMP signaling at the neural plate border
Summary: The Wnt receptor Ror2 links planar cell polarity and cell movements during gastrulation via the upregulation of BMP signaling at the neural plate border and subsequent induction of the neural crest.
- Tcf7l1 protects the anterior neural fold from adopting the neural crest fate
Summary: In developing mouse embryos, Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.
- A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network
Summary: A novel role for the Cdx proteins at the top of the trunk neural crest gene regulatory network is revealed via a neuroectoderm-directed functional knockdown approach in mouse.
- Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations
Summary: SDF1/CXCR4 signaling lies downstream of Tbx1 during pharyngeal neural crest development, and inactivating CXCR4 causes defects that phenocopy the human DiGeorge syndrome.
- WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate
Highlighted article: A new protocol for human neural crest induction from hESCs is fast and efficient, and involves TGFβ, FGF and BMP signaling to specify the neural crest independent of neural ectoderm and mesoderm.
- Neural crest cell-autonomous roles of fibronectin in cardiovascular development
Summary: Neural crest-derived fibronectin signals through integrin α5β1 to regulate Notch activity and differentiation of neural crest cells into vascular smooth muscle.
- Revising the embryonic origin of thyroid C cells in mice and humans
Highlighted article: Mouse thyroid C cell precursors arise in foregut endoderm, and not the neural crest, disproving the current concept of a neural crest origin of thyroid neuroendocrine cells.
- Human epidermal neural crest stem cells as a source of Schwann cells
Summary: Human epidermal neural crest stem cells isolated from the bulge of hair follicles are used to derive Schwann cells that could be useful for regenerative therapies, disease modelling and drug discovery.
- Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest
Highlighted article: Direct interaction between the Hippo effector Yap and the Notch intracellular domain regulates Notch target gene expression during vascular smooth muscle differentiation from neural crest.