- Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Summary: The transcription factor Helios regulates G1-S transition to promote neuronal differentiation of a striatopallidal neuronal subpopulation involved in motor skill acquisition.
- Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration
Summary: Neuroepithelial cells are the predominant stem cell type to support cerebellar regeneration after injury in Zebrafish, as opposed to radial glia-like cells, which play a relatively minor role.
- Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster
Summary: Drosophila A2BP1 regulates sensory organ specification by potentiating Notch signaling, forming part of the Suppressor of Hairless complex and acting in a context-dependent manner.
- Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo
Summary: Adult c-KIT+ olfactory basal stem cells may be propagated as expansion-competent BMI1+ progenitors in culture and provide insight into olfactory homeostasis.
- A gene regulatory network for apical organ neurogenesis and its spatial control in sea star embryos
Summary: The progression of apical organ neurogenesis in sea star larvae is controlled by the formation of nested concentric domains of gene expression along the anteroposterior axis.
- Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons
Highlighted article: The FERM domain protein Epb41l5 competes with the Notch ligand Delta as a substrate for Mib1 E3 ligase to coordinate neuronal specification and differentiation at the post-translational level.
- Minibrain drives the Dacapo-dependent cell cycle exit of neurons in the Drosophila brain by promoting asense and prospero expression
Summary: Minibrain regulates the birth of neurons in the Drosophila brain by driving a transcriptional network that coordinates neurogenesis, cell cycle and terminal differentiation.
- Crucial roles of the Arp2/3 complex during mammalian corticogenesis
Summary: During mouse cortical development, the Arp2/3 actin branching complex regulates process formation and the maintenance of radial glial cell polarity, as well as affecting neuronal migration.
- Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals
Summary: During mouse retinogenesis, the Sip1 transcription factor participates in the gene regulatory network that controls timely cell cycle exit and differentiation of a subset of retinal progenitor cells.
- Direct neuronal reprogramming: learning from and for development
Summary: This Review discusses how developmental studies have set the stage for direct neuronal reprogramming approaches and how direct conversion can shed light on unsolved questions in developmental biology.