- Dissecting the stem cell niche with organoid models: an engineering-based approach
Summary: This Review article discusses how organoids have been used to model and characterize stem cell-niche interactions and how new engineering approaches enable systematic study of the stem cell niche.
- Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion
Summary: PI3-kinase-dependent regulation of DE-cadherin controls cell adhesion between Drosophila neuroblasts and neighboring cortex glia, and between neuroblasts and their daughter cells.
- DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary.
- The stem cell niche finds its true north
Summary: This Meeting Review highlights the advances presented at the third ‘Stem Cell Niche’ meeting, which was held in Denmark in May 2016 and covered diverse aspects of embryonic and adult stem cell biology.
- Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary
Highlighted article: Manipulating expression of the transcription factor Chinmo in Drosophila gonads shows that sexual identity can be reprogrammed, and must be actively maintained throughout life.
- COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary
Summary: A COP9-Hh signaling axis, which partly represses BMP signaling, is required in the Drosophila ovary to control germline stem cell lineage specification within the differentiation niche.
- Activin signaling balances proliferation and differentiation of ovarian niche precursors and enables adjustment of niche numbers
Summary: In the Drosophila ovary, terminal filament cell development is regulated by activin, which, along with the hormone ecdysone, controls expression of the key transcription factor Broad-Z1.