- TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway
Summary: Transactivation response element RNA-binding protein (TRBP) acts as a transcriptional coactivator of the Notch pathway and regulates neural stem cells during brain development in mice.
- Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster
Summary: Drosophila A2BP1 regulates sensory organ specification by potentiating Notch signaling, forming part of the Suppressor of Hairless complex and acting in a context-dependent manner.
- Reciprocal signaling by Wnt and Notch specifies a muscle precursor in the C. elegans embryo
Highlighted article: Generation of muscle from one specific C. elegans 8-cell stage blastomere requires two cell-cell interactions. Notch-induced zygotic MOM-2 (Wnt) is responsible for both interactions.
- Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner
Summary: Forced activation of Wnt signaling in the sensory domain of the developing cochlea impacts radial patterning and downstream gene expression in a spatiotemporal manner.
- Notch signaling promotes nephrogenesis by downregulating Six2
Summary: Notch is necessary and sufficient for downregulation of Six2 during nephrogenesis, while nephron progenitors that lack Notch signaling fail to form all segments of the nephron, not just proximal tubules.
- Mapping lineage progression of somatic progenitor cells in the mouse fetal testis
Highlighted Article: Somatic progenitor cell populations in the mouse testis are defined by progressive lineage-specific acquirement of WT1, HES1, SOX9 and GLI1 beginning at the time of sex determination.
- sequoia controls the type I>0 daughter proliferation switch in the developing Drosophila nervous system
Summary: During Drosophila embryonic CNS development, the zinc-finger protein Sequoia interacts with the Notch pathway to control lineage progression.
- The evolutionarily conserved transcription factor Sp1 controls appendage growth through Notch signaling
Summary: Analysis of the transcription factor Sp1 in the fly leg reveals its key role in regulating segmentation, acting at least in part through the Notch ligand Serrate.
- Ebi modulates wing growth by ubiquitin-dependent downregulation of Crumbs in Drosophila
Summary: In the fly wing, the transmembrane protein Crumbs antagonises Notch signalling. Crumbs, in turn, is inhibited by the WD40 domain protein Ebi, thus promoting Notch activity.