Notch signaling
- Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity
Summary: Loss of expression of zinc-finger transcription factor Nerfin-1 in early-stage medullar neurons activates Notch signaling and promotes neuron-to-neuroblast reversion.
- Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling
Summary: Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, regulates morphogenesis, differentiation and cell survival of the duodenum, by modulating expression of Notch pathway ligands.
- Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons
Highlighted article: The FERM domain protein Epb41l5 competes with the Notch ligand Delta as a substrate for Mib1 E3 ligase to coordinate neuronal specification and differentiation at the post-translational level.
- Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway
Summary: In the mouse corneal epithelium, primary cilia are confined to basal cells and modulate Notch signaling and cell proliferation to maintain normal epithelial thickness.
- Meis1 coordinates a network of genes implicated in eye development and microphthalmia
Summary: The transcription factor Meis1 controls expression of a set of eye territory-specific transcription factors. Meis1 haploinsufficiency causes micropthalmia and visual impairment in adult mice.
- Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest
Highlighted article: Direct interaction between the Hippo effector Yap and the Notch intracellular domain regulates Notch target gene expression during vascular smooth muscle differentiation from neural crest.
- UXT potentiates angiogenesis by attenuating Notch signaling
Summary: UXT/ART27 is a novel repressor of Notch signaling that impairs the interaction between NICD and RBP-Jκ/CSL and is indispensable for zebrafish intersegmental vessel formation.