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Notch signaling

  • RESEARCH ARTICLE
    Redundancy and cooperation in Notch intercellular signaling
    Juan C. Luna-Escalante, Pau Formosa-Jordan, Marta Ibañes
    Development 2018 145: dev154807 doi: 10.1242/dev.154807 Published 10 January 2018

    Summary: Modeling of Notch signaling when activated by more than one type of ligand suggests that ligands with different efficiencies can cooperate to drive new spatial coordination of cell signaling states.

  • STEM CELLS AND REGENERATION
    Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation
    Marcelo Boareto, Dagmar Iber, Verdon Taylor
    Development 2017 144: 3465-3474; doi: 10.1242/dev.152520

    Summary: Computational analysis of transcriptome data from neural stem cells reveals key differences in the synergistic interactions between Notch and inhibitor of DNA-binding factors during embryonic and adult neurogenesis.

  • RESEARCH ARTICLE
    Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity
    Jiajun Xu, Xue Hao, Meng-Xin Yin, Yi Lu, Yunyun Jin, Jinjin Xu, Ling Ge, Wenqing Wu, Margaret Ho, Yingzi Yang, Yun Zhao, Lei Zhang
    Development 2017 144: 1510-1517; doi: 10.1242/dev.141341

    Summary: Loss of expression of zinc-finger transcription factor Nerfin-1 in early-stage medullar neurons activates Notch signaling and promotes neuron-to-neuroblast reversion.

  • RESEARCH ARTICLE
    Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling
    Yutaka Takada, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
    Development 2016 143: 3532-3539; doi: 10.1242/dev.141549

    Summary: Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, regulates morphogenesis, differentiation and cell survival of the duodenum, by modulating expression of Notch pathway ligands.

  • STEM CELLS AND REGENERATION
    Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons
    Miho Matsuda, Kinneret Rand, Greg Palardy, Nobuyuki Shimizu, Hiromi Ikeda, Damian Dalle Nogare, Motoyuki Itoh, Ajay B. Chitnis
    Development 2016 143: 3085-3096; doi: 10.1242/dev.138743

    Highlighted article: The FERM domain protein Epb41l5 competes with the Notch ligand Delta as a substrate for Mib1 E3 ligase to coordinate neuronal specification and differentiation at the post-translational level.

  • RESEARCH ARTICLE
    Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway
    Laura Grisanti, Ekaterina Revenkova, Ronald E. Gordon, Carlo Iomini
    Development 2016 143: 2160-2171; doi: 10.1242/dev.132704

    Summary: In the mouse corneal epithelium, primary cilia are confined to basal cells and modulate Notch signaling and cell proliferation to maintain normal epithelial thickness.

  • RESEARCH ARTICLE
    Meis1 coordinates a network of genes implicated in eye development and microphthalmia
    Séverine Marcos, Monica González-Lázaro, Leonardo Beccari, Laura Carramolino, Maria Jesus Martin-Bermejo, Oana Amarie, Daniel Mateos-San Martín, Carlos Torroja, Ozren Bogdanović, Roisin Doohan, Oliver Puk, Martin Hrabě de Angelis, Jochen Graw, Jose Luis Gomez-Skarmeta, Fernando Casares, Miguel Torres, Paola Bovolenta
    Development 2015 142: 3009-3020; doi: 10.1242/dev.122176

    Summary: The transcription factor Meis1 controls expression of a set of eye territory-specific transcription factors. Meis1 haploinsufficiency causes micropthalmia and visual impairment in adult mice.

  • RESEARCH ARTICLE
    Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest
    Lauren J. Manderfield, Haig Aghajanian, Kurt A. Engleka, Lillian Y. Lim, Feiyan Liu, Rajan Jain, Li Li, Eric N. Olson, Jonathan A. Epstein
    Development 2015 142: 2962-2971; doi: 10.1242/dev.125807

    Highlighted article: Direct interaction between the Hippo effector Yap and the Notch intracellular domain regulates Notch target gene expression during vascular smooth muscle differentiation from neural crest.

  • RESEARCH ARTICLES
    UXT potentiates angiogenesis by attenuating Notch signaling
    Yi Zhou, Rui Ge, Rui Wang, Feng Liu, Yuefeng Huang, Heng Liu, Yan Hao, Qin Zhou, Chen Wang
    Development 2015 142: 774-786; doi: 10.1242/dev.112532

    Summary: UXT/ART27 is a novel repressor of Notch signaling that impairs the interaction between NICD and RBP-Jκ/CSL and is indispensable for zebrafish intersegmental vessel formation.

  • STEM CELLS AND REGENERATION
    RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche
    Thomas Xavier Garcia, Jaspreet Kaur Farmaha, Sean Kow, Marie-Claude Hofmann
    Development 2014 141: 4468-4478; doi: 10.1242/dev.113969

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