Notch signaling
- Stratum recruits Rab8 at Golgi exit sites to regulate the basolateral sorting of Notch and Sanpodo
Summary: Stratum, the putative guanine nucleotide exchange factor for Rab GTPases, is involved in restricting the apical delivery of Sanpodo to control spatiotemporal Notch activation following asymmetric cell division in Drosophila sensory organs.
- Redundancy and cooperation in Notch intercellular signaling
Summary: Modeling of Notch signaling when activated by more than one type of ligand suggests that ligands with different efficiencies can cooperate to drive new spatial coordination of cell signaling states.
- Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation
Summary: Computational analysis of transcriptome data from neural stem cells reveals key differences in the synergistic interactions between Notch and inhibitor of DNA-binding factors during embryonic and adult neurogenesis.
- Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity
Summary: Loss of expression of zinc-finger transcription factor Nerfin-1 in early-stage medullar neurons activates Notch signaling and promotes neuron-to-neuroblast reversion.
- Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling
Summary: Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, regulates morphogenesis, differentiation and cell survival of the duodenum, by modulating expression of Notch pathway ligands.
- Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons
Highlighted article: The FERM domain protein Epb41l5 competes with the Notch ligand Delta as a substrate for Mib1 E3 ligase to coordinate neuronal specification and differentiation at the post-translational level.
- Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway
Summary: In the mouse corneal epithelium, primary cilia are confined to basal cells and modulate Notch signaling and cell proliferation to maintain normal epithelial thickness.
- Meis1 coordinates a network of genes implicated in eye development and microphthalmia
Summary: The transcription factor Meis1 controls expression of a set of eye territory-specific transcription factors. Meis1 haploinsufficiency causes micropthalmia and visual impairment in adult mice.
- Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest
Highlighted article: Direct interaction between the Hippo effector Yap and the Notch intracellular domain regulates Notch target gene expression during vascular smooth muscle differentiation from neural crest.
- UXT potentiates angiogenesis by attenuating Notch signaling
Summary: UXT/ART27 is a novel repressor of Notch signaling that impairs the interaction between NICD and RBP-Jκ/CSL and is indispensable for zebrafish intersegmental vessel formation.