- Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids
Summary: In human cerebral organoids, depletion of the tumor suppressor retinoblastoma protein disrupts proliferation, promotes entry into S-phase, and causes increased apoptosis and aberrant neuronal migration.
- In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development
Summary: Human embryonic stem cell-derived intestinal organoids can be patterned into duodenum-like or ileum-like tissue, recapitulating in vivo human development.
- Self-organising aggregates of zebrafish retinal cells for investigating mechanisms of neural lamination
Summary: Müller glia cells, but not retinal pigmented epithelial cells, are crucial for retinal cell lamination in retinal organoids grown in vitro.
- Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels
Summary: Culturing conventional mouse intestinal organoid cultures in contracting collagen gel induces the formation of macroscopic tubes, with all major cell types and crypt- and villus-like domains.
- Dissecting the stem cell niche with organoid models: an engineering-based approach
Summary: This Review article discusses how organoids have been used to model and characterize stem cell-niche interactions and how new engineering approaches enable systematic study of the stem cell niche.
- From stem cells to human development: a distinctly human perspective on early embryology, cellular differentiation and translational research
Summary: This Meeting Review summarises the major themes and results presented at the second 'From Stem Cells to Human Development' meeting, held in October 2016.
- The stem cell niche finds its true north
Summary: This Meeting Review highlights the advances presented at the third ‘Stem Cell Niche’ meeting, which was held in Denmark in May 2016 and covered diverse aspects of embryonic and adult stem cell biology.
- Quantification of regenerative potential in primary human mammary epithelial cells
Summary: An assay in which single, freshly isolated human mammary epithelial cells are cultured in a matrix environment is developed and used to quantify the regenerative potential of human mammary cells.