- In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development
Summary: Human embryonic stem cell-derived intestinal organoids can be patterned into duodenum-like or ileum-like tissue, recapitulating in vivo human development.
- Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish
Summary: This Development at a Glance article summarises how knowledge gained from developmental biology can be used to guide human in vitro organogenesis, and discusses the potential applications of this technology.
- Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis
Summary: This Review article discusses the basic physical and biological principles that underlie the self-organization of embryonic stem cells into organoids, and how this informs human development.
- Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians
- Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl
Summary: A unique transcriptional program that regulates the coordination of positional information and tissue differentiation in regenerating salamander limbs and tails .
- Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints
Summary: Analyses of Drosophila BMP ligands suggest that structural changes based on N-glycosylation motifs are subject to evolutionary constraints and can impact developmental processes.
- An ancestral stomatal patterning module revealed in the non-vascular land plant Physcomitrella patens
Summary: The genetic module controlling patterning of stomata in vascular plants also functions in non-vascular plants, consistent with the idea that it represents an ancestral mechanism in plant evolution.
- A unique stylopod patterning mechanism by Shox2-controlled osteogenesis
Highlighted article: A Shox2-coordinated transcriptional program functions in the osteogenic lineage to regulate Hox-TALE factors and skeletogenesis, and to pattern the mouse limb.
- Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning
Summary: In the fly notum, a reciprocal relationship between Notch signalling and cell cycle progression acts like a clock, providing a delimited window of time during which cells decide their fate.
- Development-on-chip: in vitro neural tube patterning with a microfluidic device
Summary: A microfluidic device mimics the spatial and temporal environment of neural tube development in vivo and enables the correct spatial organization of neural tube formation from stem cells in vitro.