- A systems-level approach reveals new gene regulatory modules in the developing ear
Summary: Transcriptome analysis and knock down of select transcription factors reveals a genetic hierarchy as cells become committed to inner ear fate.
- LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development
Summary: In different regions of the mouse oral epithelium, differential subcellular localization of the spindle orientation protein LGN regulates distinct patterns of cell division.
- Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth
Summary: Loss of LHX2 replicates a subset of the phenotypes seen in embryos with reduced NF-κB signaling, while exogenous TGFβ2 can rescue this effect in Lhx2 knockout skin explants.
- Epithelial stratification and placode invagination are separable functions in early morphogenesis of the molar tooth
Summary: During tooth development in mice, FGF-dependent vertical cell divisions thicken the tooth placode while Shh drives cell rearrangements that cause invagination.