Pluripotent stem cells
- In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development
Summary: Human embryonic stem cell-derived intestinal organoids can be patterned into duodenum-like or ileum-like tissue, recapitulating in vivo human development.
- Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish
Summary: This Development at a Glance article summarises how knowledge gained from developmental biology can be used to guide human in vitro organogenesis, and discusses the potential applications of this technology.
- Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naïve from primed pluripotent stem cells
Highlighted Article: Reporter mice harbouring gene cassettes encoding two different fluorescent proteins inserted into specific loci in the X chromosomes are used to study X chromosome status in vivo.
- An overview of mammalian pluripotency
Summary: This Development at a Glance article summarises mammalian pluripotency both in vivo and in vitro, and highlights recent and future applications of PSCs for basic and translational research.
- On human development: lessons from stem cell systems
Summary: A recent Company of Biologists Workshop brought together a diverse group of scientists with a common interest in understanding human development.