- Control of lens development by Lhx2-regulated neuroretinal FGFs
Summary: The LIM homeodomain transcription factor Lhx2 regulates FGF3, FGF9 and FGF15 and is essential for lens cell proliferation, survival and differentiation in mice.
- cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner
Summary: During zebrafish angiogenesis, endothelial PKA activity regulates the transition from sprouting to stabilisation of nascent vessels, preventing excessive tip cell formation and hypersprouting.
- Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals
Summary: During mouse retinogenesis, the Sip1 transcription factor participates in the gene regulatory network that controls timely cell cycle exit and differentiation of a subset of retinal progenitor cells.
- mTor signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina
Highlighted article: Inhibition of mTor signaling in vivo prevents the proliferation of Müller glia cells and blocks the regenerative response in the chick retina.
- De novo neurogenesis by targeted expression of atoh7 to Müller glia cells
Highlighted article: Induced activation of atoh7 in Müller glia cells in vivo is sufficient to drive cell cycle re-entry and proliferation, followed by the formation of neurogenic clusters and de novo neurogenesis.
- Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors
Summary: Bmi1 is required to prevent postnatal degeneration of cone photoreceptors and bipolar neurons, while BMI1 inactivation in human embryonic stem cells impairs cone terminal differentiation.
- The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue
Summary: A quantitative study of cell proliferation and fate choice in the zebrafish retina - a continuously growing neural tissue - reveals key features of late retinal neurogenesis.
- The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina
Highlighted article: LGN inactivation in mice disrupts spindle orientation in both the retina and neocortex but leads to very different outcomes with regards to cell fate in each context.
- Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina
Summary: In the fish eye, Hh signalling from the ventral forebrain regulates spatial identity in the retina by promoting foxd1 expression. This role is required only in the presence of Fgf activity.
- Photoreceptor cell fate specification in vertebrates
Summary: This Review discusses recent progress in the understanding of the mechanisms of photoreceptor specification from neural progenitors and their implications for the treatment of retinal diseases.