- Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids
Summary: In human cerebral organoids, depletion of the tumor suppressor retinoblastoma protein disrupts proliferation, promotes entry into S-phase, and causes increased apoptosis and aberrant neuronal migration.
- Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator
Summary: Although the Drosophila insulin gene is broadly expressed, its regulation is complex - with multiple cis-regulatory elements integrating nutritional and tissue-specific inputs.
- Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma
Summary: The SWI/SNF protein Brg1 controls cell cycle length, cell cycle exit and cell survival, and is required for cell differentiation and retinal lamination, in the developing mouse retina.