- Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscle in vivo
Summary: In Drosophila, immature myofibrils are built simultaneously across an entire muscle fiber, and then self-organize in a manner dependent on spontaneous contractions and mechanical tension.
- Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle
Summary: Deletion of tropomodulin 4 induces compensatory upregulation of tropomodulin 1 to preserve thin filament lengths in mouse skeletal muscle. Knockdown of tropomodulin 1 results in increased thin filament lengths.