Self-organization
- Generation of thalamic neurons from mouse embryonic stem cells
Highlighted article: Using 3D self-organizing culture techniques, thalamic progenitors can be induced from mouse embryonic stem cells, and show appropriate gene expression and axonal projection patterns.
- Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscle in vivo
Summary: In Drosophila, immature myofibrils are built simultaneously across an entire muscle fiber, and then self-organize in a manner dependent on spontaneous contractions and mechanical tension.
- Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis
Summary: This Review article discusses the basic physical and biological principles that underlie the self-organization of embryonic stem cells into organoids, and how this informs human development.
- Inhibition of Shh signalling in the chick wing gives insights into digit patterning and evolution
Highlighted Article: In the chick wing, the relative timing of the specification of antero-posterior positional values and self-organising mechanisms determines digit patterning and identity.