- Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells
Summary: This Review article summarizes the current state-of-the-art retinal stem cell therapies, and highlights the essential role of developmental biology in moving this field forward.
- Enthesis regeneration: a role for Gli1+ progenitor cells
Summary: Tendon enthesis progenitor cells are capable of healing enthesis injuries in immature mice, in a hedgehog pathway-dependent manner. This capacity is lost in mature animals.
- Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion
Summary: PI3-kinase-dependent regulation of DE-cadherin controls cell adhesion between Drosophila neuroblasts and neighboring cortex glia, and between neuroblasts and their daughter cells.
- Metabolic remodeling during the loss and acquisition of pluripotency
Summary: This Review discusses the metabolic remodelling that occurs during the transitions between different states of pluripotency and commitment, both in vitro and in the early mammalian embryo.
- Nipped-A regulates intestinal stem cell proliferation in Drosophila
Summary: Balanced expression of Nipped-A prevents hyperproliferation of intestinal stem cells in aged Drosophila midguts, identifying Nipped-A as a novel regulator of stem cell proliferation.
- ID4 levels dictate the stem cell state in mouse spermatogonia
Summary: The level of ID4 expression distinguishes stem cells and immediate progenitors in mammalian spermatogonial cells, while downregulation of ID4 is required for transition between the functional states.
- Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling
Summary: Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, regulates morphogenesis, differentiation and cell survival of the duodenum, by modulating expression of Notch pathway ligands.
- The stem cell niche finds its true north
Summary: This Meeting Review highlights the advances presented at the third ‘Stem Cell Niche’ meeting, which was held in Denmark in May 2016 and covered diverse aspects of embryonic and adult stem cell biology.
- The EGFR signaling pathway controls gut progenitor differentiation during planarian regeneration and homeostasis
Summary: EGFR signaling promotes the differentiation of stem cell-derived progenitors into mature gut cells during both normal homeostasis and regeneration of the planarian Schmidtea mediterranea.
- Development-on-chip: in vitro neural tube patterning with a microfluidic device
Summary: A microfluidic device mimics the spatial and temporal environment of neural tube development in vivo and enables the correct spatial organization of neural tube formation from stem cells in vitro.