- The hope and the hype of organoid research
Summary: This Spotlight article discusses the exciting promise of organoid technology, as well as the current limitations and what it will take to overcome them.
- Ethical issues in human organoid and gastruloid research
Summary: This Spotlight article summarizes some of the important ethical issues associated with research involving human organoids and other complex self-organized structures.
- Lung organoids: current uses and future promise
Summary: This Review article explores the latest advances in both adult and embryonic stem cell-derived lung organoid culture, and discusses how these systems can be used to understand homeostasis and regeneration.
- The physics of organoids: a biophysical approach to understanding organogenesis
Summary: This Spotlight article discusses some interesting applications of physics in organoid research, from computational modeling of organoid biology to understanding mechanical aspects of organ development.
- Bringing together the organoid field: from early beginnings to the road ahead
Summary: This Meeting Review summarises the major findings and themes that emerged from the 2016 EMBOǀEMBL Symposium entitled ‘Organoids: modelling organ development and disease in 3D culture’.
- Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians
- Krüppel-like factors in mammalian stem cells and development
Summary: This Primer article provides an overview of Krüppel-like factors (KLFs), a family of zinc-finger transcription factors that play fundamental roles in development.
- Understanding development and stem cells using single cell-based analyses of gene expression
Summary: This Review discusses how single cell RNA sequencing has been used to study developmental and stem cell biology, providing insights into cell type diversity and developmental dynamics.
- Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells
Summary: The C. elegans PUF protein FBF-2, but not its homolog FBF-1, directly binds dynein light chain DLC-1, regulating FBF-2 localization and activity in a dynein motor-independent manner.
- Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming
Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.