- Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues
Summary: Proper differentiation of somatic cyst stem cells as they move away from their niche requires an increase in PI3K/Tor signaling, downstream of Insulin receptor activation.
- Mapping lineage progression of somatic progenitor cells in the mouse fetal testis
Highlighted Article: Somatic progenitor cell populations in the mouse testis are defined by progressive lineage-specific acquirement of WT1, HES1, SOX9 and GLI1 beginning at the time of sex determination.
- Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes
Summary: A large-scale RNAi screen in Drosophila testes reveals that many genes involved in protein synthesis and degradation are required for the homeostasis of germline stem cells and their niches.
- SUMO regulates somatic cyst stem cell maintenance and directly targets the Hedgehog pathway in adult Drosophila testis
Summary: SUMOylation promotes proliferation of cyst stem cells in the Drosophila testis. The transcription factor Ci is SUMOylated, enhancing Hedgehog pathway activity in these cells.
- Of sex and determination: marking 25 years of Randy, the sex-reversed mouse
Summary: This Spotlight revisits a landmark paper in developmental biology, published 25 years ago, that reported the sex reversal of an XX mouse carrying an Sry transgene.
- Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes
Highlighted article: Upregulation of replication-dependent core histone genes by retinoic acid signaling contributes to spermatogonial differentiation in mice.
- Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary
Highlighted article: Manipulating expression of the transcription factor Chinmo in Drosophila gonads shows that sexual identity can be reprogrammed, and must be actively maintained throughout life.
- Bi-directional gap junction-mediated soma-germline communication is essential for spermatogenesis
Summary: Soma and germline communicate bi-directionally through gap-junctions to promote germline differentiation and stem cell maintenance during fly spermatogenesis.
- UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome
Summary: Sertoli cell-specific disruption of upf2, a component of the nonsense-mediated decay machinery, leads to global defects in transcription, Sertoli and germ cell depletion, and sterility.