- Conserved and novel functions of programmed cellular senescence during vertebrate development
Summary: Cellular senescence is an intrinsic part of the developmental programme in amphibians and has a conserved role in vertebrate organogenesis.
- On the development of the patella
HIGHLIGHTED ARTICLE: The patella originates from a pool of Sox9- and Scx-positive progenitors that is separated from the femur during the process of joint formation, which in turn is regulated by mechanical load.
- Regulation by a TGFβ-ROCK-actomyosin axis secures a non-linear lumen expansion that is essential for tubulogenesis
Highlighted article: Tubule morphogenesis in the Ciona intestinalis notochord is a non-linear process driven by the TGFβ-ROCK-mediated regulation of actomyosin contractility and Slc26-induced osmotic pressure.