Vascular patterning
- Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology
Highlighted article: Collagen I is deposited by osteoblasts onto endothelial cells within bone and serves as a template for mineralisation, with ossification thus spatially and temporally following vascular patterning.
- Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning
Summary: Intravital dye labeling and 3D imaging reveal that Pbx1-mediated vascular mural cell differentiation is required for the repression of PDGFRβ signaling and functional renal vascularization in mice.
- Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism
Highlighted article: The vascularization of limb interdigital regions leads to an increase in tissue oxygenation that, in turn, triggers ROS production and cell death during mouse limb development.