- Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs
Summary: Genome-wide analysis of Wnt and BMP targets in the Xenopus gut endoderm reveals cooperation and crosstalk between these pathways through integration of Smad1 and β-catenin on cis-regulatory elements.
- Reciprocal signaling by Wnt and Notch specifies a muscle precursor in the C. elegans embryo
Highlighted article: Generation of muscle from one specific C. elegans 8-cell stage blastomere requires two cell-cell interactions. Notch-induced zygotic MOM-2 (Wnt) is responsible for both interactions.
- An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation
Summary: The analysis of Xenopus loss-of-function mutants reveals that Sipa1l3 – a gene associated with congenital cataracts in humans – interacts with Epha4 signaling to regulate retinal and lens development.
- Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition
Summary: Epithelial morphogenesis during the transition from the early to late stage of lung development is coordinated by the activity of Wnt signaling.
- Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development
Summary: In the meibomian glands of the mouse eyelid, dynamic regulation of Dkk4 activity by proteolytic cleavage and interaction with Lrp6 modulates Wnt pathway activity and hence gland development.
- Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2
Summary: Osteoblast specification requires regulatory inputs from BMP2 at the Runx2/Osx1 transition by a mechanism that is not compensated for by canonical Wnt signaling and involves Grhl3.
- Localization of planarian β-CATENIN-1 reveals multiple roles during anterior-posterior regeneration and organogenesis
Summary: Immunohistochemistry reveals an anteroposterior gradient of nuclear β-CATENIN-1 in the adult planarian, with the lowest levels in the pre-pharyngeal region and the highest levels at the tip of the tail.
- Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner
Summary: Forced activation of Wnt signaling in the sensory domain of the developing cochlea impacts radial patterning and downstream gene expression in a spatiotemporal manner.