- R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways
Summary: R-spondin 1, a Wnt co-factor, regulates the expression of components of the parallel pathways Wnt16/DeltaC/DeltaD and Vegfa/Tgfβ1, required for specification of hematopoietic stem cells.
- The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance
Summary: Mammalian neurogenins are proneural factors, but the Drosophila homolog Tap is not, instead acting to prevent axonal outgrowth, likely by regulating the planar cell polarity pathway via Dishevelled.
- Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin
Summary: The analysis of Drosophila embryos lacking APC reveals a diverse set of post-translational modifications that are dependent on APC, one of which regulates β-catenin abundance.
- Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS
Summary: The tumour suppressor APC is required by Schwann cells for their timely differentiation to mature myelinating cells; conditional knockout mice display hindlimb weakness and impaired axonal conduction.
- Tcf7l1 protects the anterior neural fold from adopting the neural crest fate
Summary: In developing mouse embryos, Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient.
- Development of the aboral domain in Nematostella requires β-catenin and the opposing activities of Six3/6 and Frizzled5/8
Summary: Wnt signalling and the Six3/6 transcription factors play conserved functions in primary axis patterning in bilateria, controlling aboral/anterior identity in Nematostella.
- Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point
Summary: Calsyntenin 1 and RabGDI contribute to cargo-specific vesicle trafficking in axonal pathfinding, leading to tightly regulated surface expression of guidance receptors at choice points.
- Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling
Summary: Radial glia in the larval zebrafish hypothalamus exhibit stem cell-like properties. Their self-renewal is Wnt independent, although Wnt signalling does regulate their differentiation.
- Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain
Highlighted article: Restoration of brain:body proportion after injury in planarians involves spatial Wnt/Notum feedback inhibition to control brain cell differentiation and target organ size.
- Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling
Highlighted article: Hoxc8 misexpression in cervical somites and the overlying ectoderm of mice can convert skin into mammary ectoderm, with subsequent placode, bud and sprout development.