- FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition
Summary: FGF signaling is required for post-gastrula paraxial mesoderm induction through a unique mechanism that differs from its role during gastrula stage mesoderm induction.
- Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis
Summary: Genetic analyses of Esama function in mutant zebrafish embryos reveal specific and redundant functions of Esama and VE-cadherin proteins in endothelial cell recognition and blood vessel morphogenesis.
- Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration
Summary: Neuroepithelial cells are the predominant stem cell type to support cerebellar regeneration after injury in Zebrafish, as opposed to radial glia-like cells, which play a relatively minor role.
- Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone
- FGF signaling enforces cardiac chamber identity in the developing ventricle
Summary: The FGF signaling pathway suppresses plasticity in the developing ventricle by promoting ventricular chamber characteristics and inhibiting atrial gene expression via Nkx factors.
- R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways
Summary: R-spondin 1, a Wnt co-factor, regulates the expression of components of the parallel pathways Wnt16/DeltaC/DeltaD and Vegfa/Tgfβ1, required for specification of hematopoietic stem cells.
- Cell division and cadherin-mediated adhesion regulate lens epithelial cell movement in zebrafish
Summary: Time-lapse imaging of zebrafish lens epithelium reveals that cell division and cadherin-mediated adhesion regulate lens epithelial cell movement via modulation of epithelial tension.
- An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates
Summary: Lineage tracing approaches in zebrafish reveal that intestinal smooth muscle originates from the lateral plate mesoderm. Migration and differentiation of these cells involves TGFβ signaling.
- TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control
Summary: Re-engineering the blue light-activated EL222 system, renamed TAEL, provides optogenetic gene expression that enables robust spatial and temporal regulation of gene expression in zebrafish.