- Cell division and cadherin-mediated adhesion regulate lens epithelial cell movement in zebrafish
Summary: Time-lapse imaging of zebrafish lens epithelium reveals that cell division and cadherin-mediated adhesion regulate lens epithelial cell movement via modulation of epithelial tension.
- R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways
Summary: R-spondin 1, a Wnt co-factor, regulates the expression of components of the parallel pathways Wnt16/DeltaC/DeltaD and Vegfa/Tgfβ1, required for specification of hematopoietic stem cells.
- An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates
Summary: Lineage tracing approaches in zebrafish reveal that intestinal smooth muscle originates from the lateral plate mesoderm. Migration and differentiation of these cells involves TGFβ signaling.
- TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control
Summary: Re-engineering the blue light-activated EL222 system, renamed TAEL, provides optogenetic gene expression that enables robust spatial and temporal regulation of gene expression in zebrafish.
- Interactions between mural cells and endothelial cells stabilize the developing zebrafish dorsal aorta
Summary: Vascular smooth muscle cells are required to help maintain the vascular basement membrane and promote vessel stabilization during development.
- Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish
Summary: Zar1 RNA binding protein represses zona pellucida RNA translation during early oogenesis. zar1 deletion mutants show ER stress and apoptosis in oocytes and result in an all-male phenotype.
- Defective adgra2 (gpr124) splicing and function in zebrafish ouchless mutants
Summary: ouchless phenotypes are attributed to an essential splice site mutation affecting adgra2 (gpr124) splicing and function, rather than to downregulated sorbs3 transcript levels, as previously thought.
- Exon- and contraction-dependent functions of titin in sarcomere assembly
Summary: A set of zebrafish titin deletion mutations in Z-disk and A-band domains provides a model to interrogate the mechanisms underlying heterogeneous functions of titin-truncating variants.
- Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca
- Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons
Summary: Tamoxifen-induced Caspase activation in zebrafish enables fast, efficient and specific cell ablation via targeted apoptosis.