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JOURNAL ARTICLES
The involvement of the Notch locus in Drosophila oogenesis
T. Xu, L.A. Caron, R.G. Fehon, S. Artavanis-Tsakonas
Development 1992 115: 913-922;

Summary

The Notch gene in Drosophila encodes a transmembrane protein with homology to EGF that, in a variety of tissues, appears to mediate cell interactions necessary for cell fate choices. Here we demonstrate that oogenesis and spermatogenesis depend on Notch. We examine the phenotypes of the temperature-sensitive Notch allele, Nts1, and, using a monoclonal antibody, determine the cellular and subcellular distribution of Notch protein during oogenesis. We show that Nts1 is associated with a missense mutation in the extracellular, EGF homologous region of Notch and that at non-permissive temperatures oogenesis is blocked and the subcellular distribution of the protein is altered. In wild-type ovaries, Notch protein is found on the apical surface of somatically derived follicle cells, while in the germline-derived cells the protein is not polarized. These findings are discussed in view of the hypothesis that Notch acts as a multifunctional receptor to mediate developmentally important cell interactions.

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JOURNAL ARTICLES
The involvement of the Notch locus in Drosophila oogenesis
T. Xu, L.A. Caron, R.G. Fehon, S. Artavanis-Tsakonas
Development 1992 115: 913-922;
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