Advertisement
JOURNAL ARTICLES
Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall
S.J. Gaunt, M. Blum, E.M. De Robertis
Development 1993 117: 769-778;

Summary

After an earlier, transient phase of expression in the developing primitive streak of 6.4- to 6.8-day mouse embryos, the homeobox gene goosecoid is now shown to be expressed in a later phase of mouse development, from 10.5 days onwards. The later, spatially restricted domains of goosecoid expression are detected in the head, limbs and ventrolateral body wall. At all sites, the domains of expression are first detected in undifferentiated tissue, and then expression persists as these tissues undergo subsequent morphogenesis. For example, goosecoid expression is noted in the first branchial arch at 10.5 days, and then expression persists as this tissue undergoes morphogenesis to form the lower jaw and the body of the tongue. Expression in tissues around the first branchial cleft persists as these undergo morphogenesis to form the base of the auditory meatus and eustachian tube. Expression in tissues around the newly formed nasal pits persists as these elongate to form the nasal chambers. Expression in the ventral epithelial lining of the otic vesicle persists as this eventually gives rise to the non-sensory epithelium of the cochlea. Expression in the proximal limb buds and ventrolateral body wall persists as these tissues undergo morphogenesis to form proximal limb structures and ventral ribs respectively. Our findings lead us to suggest that the goosecoid gene product plays a role in spatial programming within discrete embryonic fields, and possibly lineage compartments, during organogenesis stages of mouse development.

REFERENCES

    1. Blum M.,
    2. Gaunt S. J.,
    3. Cho K. W. Y.,
    4. Steinbeisser H.,
    5. Blumberg B.,
    6. Bittner D.,
    7. De Robertis E. M.
    (1992) Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097–1106
    OpenUrlCrossRefPubMedWeb of Science
    1. Blumberg B.,
    2. Wright C. V. E.,
    3. De Robertis E. M.,
    4. Cho K. W. Y.
    (1991) Organizer-specific homeobox genes in Xenopus Laevis embryos. Science 253, 194–196
    OpenUrlAbstract/FREE Full Text
    1. Cho K. W. Y.,
    2. Blumberg B.,
    3. Steinbeisser H.,
    4. De Robertis E. M.
    (1991) Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111–1120
    OpenUrlCrossRefPubMedWeb of Science
    1. De Robertis E. M.,
    2. Morita E. A.,
    3. Cho K. W. Y.
    (1991) Gradient fields and homeobox genes. Development 112, 669–678
    OpenUrlAbstract
    1. Dolle P.,
    2. Izpisùa-Belmonte J. C.,
    3. Falkenstein H.,
    4. Renucci A.,
    5. Duboule D.
    (1989) Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation. Nature 342, 767–772
    OpenUrlCrossRefPubMed
    1. Dolle P.,
    2. Price M.,
    3. Duboule D.
    (1992) Expression of the murine D1x-1 homeobox gene during facial, ocular and limb development. Differentiation 49, 93–99
    OpenUrlCrossRefPubMedWeb of Science
    1. Frohman M. A.,
    2. Boyle M.,
    3. Martin G. A.
    (1990) Isolation of the mouse Hox-2. 9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development 110, 589–607
    OpenUrlAbstract/FREE Full Text
    1. Gaunt S. J.
    (1987) Homeobox gene Hox-1. 5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation. Development 101, 51–60
    OpenUrlAbstract/FREE Full Text
    1. Gaunt S. J.
    (1991) Expression patterns of mouse Hox genes: clues to an understanding of developmental and evolutionary strategies. BioEssays 13, 505–513
    OpenUrlCrossRefPubMedWeb of Science
    1. Gaunt S. J.,
    2. Krumlauf R.,
    3. Duboule D.
    (1989) Mouse homeogenes within a subfamily, Hox-1.4, −2. 6 and -5. 1, display similar anteroposterior domains of expression in the embryo, but show stage-and tissue-dependent differences in their regulation. Development 107, 131–141
    OpenUrlAbstract
    1. Gaunt S. J.,
    2. Sharpe P. T.,
    3. Duboule D.
    (1988) Spatially restricted domains of homeogene transcripts in mouse embryos: relation to a segmented body plan. Development Suppl 104, 169–179
    OpenUrl
    1. Gavin B. J.,
    2. McMahon J. A.,
    3. McMahon A. P.
    (1990) Expression of multiple novel Wnt-1/int-1 -related genes during fetal and adult mouse development. Genes Dev 4, 2319–2332
    OpenUrlAbstract/FREE Full Text
    1. Goulding M. D.,
    2. Chalepakis G.,
    3. Deutsch U.,
    4. Erselius J. R.,
    5. Gruss P.
    (1991) Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10, 1135–1147
    OpenUrlPubMedWeb of Science
    1. Hill R. E.,
    2. Jones P. F.,
    3. Rees A. R.,
    4. Sime C. M.,
    5. Justice M. J.,
    6. Copeland N. G.,
    7. Jenkins N. A.,
    8. Graham E.,
    9. Davidson D. R.
    (1989) A new family of mouse homeobox-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7. 1. Genes Dev 3, 26–37
    OpenUrlAbstract/FREE Full Text
    1. Hunt P.,
    2. Gulisano M.,
    3. Cook M.,
    4. Sham M.,
    5. Faiella A.,
    6. Wilkinson D.,
    7. 778Boncinelli E.,
    8. Krumlauf R.
    (1991) A distinct Hox code for the branchial region of vertebrate head. Nature 353, 861–864
    OpenUrlCrossRefPubMed
    1. Hunt P.,
    2. Krumlauf R.
    (1991) Deciphering the Hox code: clues to patterning branchial regions of the head. Cell 66, 1075–1078
    OpenUrlCrossRefPubMedWeb of Science
    1. Hunt P.,
    2. Whiting J.,
    3. Muchamore I.,
    4. Marshall H.,
    5. Krumlauf R.
    (1991) Homeobox genes and models for patterning the hindbrain and branchial arches. Development 1, 187–196
    OpenUrlPubMed
    1. Ingham P. W.,
    2. Arias A. Martinez
    (1992) Boundaries and fields in early embryos. Cell 68, 221–235
    OpenUrlCrossRefPubMedWeb of Science
    1. Kirby M. L.
    (1989) Plasticity and predetermination of mesencephalic and trunk neural crest transplanted into the region of the cardiac neural crest. Dev. Biol 134, 402–412
    OpenUrlCrossRefPubMedWeb of Science
    1. Lawrence P. A.
    (1990) Compartments in vertebrates?. Nature 334, 382–383
    OpenUrl
    1. Lawson K. A.,
    2. Meneses J. J.,
    3. Pedersen R. A.
    (1991) Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891–911
    OpenUrlAbstract
    1. Lumsden A.,
    2. Sprawson N.,
    3. Graham A.
    (1991) Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113, 1281–1291
    OpenUrlAbstract
    1. Mackenzie A.,
    2. Ferguson M. W. J.,
    3. Sharpe P. T.
    (1991) Hox-7 expression during murine craniofacial development. Development 113, 601–611
    OpenUrlAbstract
    1. Mitchell P. J.,
    2. Timmons P. M.,
    3. Hebert J. M.,
    4. Rigby P. W. J.,
    5. Tjian R.
    (1991) Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev 5, 105–119
    OpenUrlAbstract/FREE Full Text
    1. Noden D. M.
    (1983) The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues. Dev. Biol 96, 144–165
    OpenUrlCrossRefPubMedWeb of Science
    1. Noden D. M.
    (1988) Interactions and fates of avian craniofacial mesenchyme. Development 103, 121–140
    OpenUrlAbstract/FREE Full Text
    1. Ott M.,
    2. Bober E.,
    3. Lyons G.,
    4. Arnold H.,
    5. Buckingham M.
    (1991) Early expression of the myogenic regulatory gene, myf −5, in precursor cells of skeletal muscle in the mouse embryo. Development 111, 1097–1107
    OpenUrlAbstract/FREE Full Text
    1. Richman J. M.,
    2. Tickle C.
    (1989) Epithelia are interchangeable between facial primordia of chick embryos and morphogenesis is controlled by the mesenchyme. Dev. Biol 136, 201–210
    OpenUrlCrossRefPubMed
    1. Robert B.,
    2. Sassoon D.,
    3. Jacq B.,
    4. Gehring W.,
    5. Buckingham M.
    (1989) Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J 8, 91–100
    OpenUrlPubMedWeb of Science
    1. Sassoon D.,
    2. Lyons G.,
    3. Wright W. E.,
    4. Lin V.,
    5. Lassar A.,
    6. Weintraub H.,
    7. Buckingham M.
    (1989) Expression of two myogenic regulatory factors myogenin and Myo D1 during mouse embryogenesis. Nature 341, 303–307
    OpenUrlCrossRefPubMed
    1. Tabin C. J.
    (1991) Retinoids, homeoboxes, and growth factors: toward molecular models for limb development. Cell 66, 199–217
    OpenUrlCrossRefPubMedWeb of Science
    1. Treisman J.,
    2. Harris E.,
    3. Wilson D.,
    4. Desplan C.
    (1992) The homeodomain: a new face for the helix-turn-helix. BioEssays 14, 145–150
    OpenUrlCrossRefPubMedWeb of Science
    1. Wilkinson D. G.,
    2. Bhatt S.,
    3. McMahon A. P.
    (1989) Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development 105, 131–136
    OpenUrlAbstract
    1. Wolf C.,
    2. Thisse C.,
    3. Stoetzel C.,
    4. Thisse B.,
    5. Gerlinger P.,
    6. Perrin-Schmitt F.
    (1991) M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus x-twi and the Drosophilatwist genes. Dev. Biol 143, 363–373
    OpenUrlCrossRefPubMedWeb of Science
Back to top

 Download PDF

Email
JOURNAL ARTICLES
Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall
S.J. Gaunt, M. Blum, E.M. De Robertis
Development 1993 117: 769-778;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Alerts

Article navigation

Other journals from The Company of Biologists

Advertisement

Kathryn Virginia Anderson (1952-2020)

Developmental geneticist Kathryn Anderson passed away at home on 30 November 2020. Tamara Caspary, a former postdoc and friend, remembers Kathryn and her remarkable contribution to developmental biology.

Zooming into 2021

In a new Editorial, Editor-in-Chief James Briscoe and Executive Editor Katherine Brown reflect on the triumphs and tribulations of the last 12 months, and look towards a hopefully calmer and more predictable year.

Read & Publish participation extends worldwide

Over 60 institutions in 12 countries are now participating in our Read & Publish initiative. Here, James Briscoe explains what this means for his institution, The Francis Crick Institute. Find out more and view our full list of participating institutions.

Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.

Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Sign up to join our next session:

10 February
Time: 13:00 (GMT)
Chaired by: preLights