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JOURNAL ARTICLES
Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions
P. Heitzler, P. Simpson
Development 1993 117: 1113-1123;

Summary

In Drosophila each neural precursor is chosen from a group of cells through cell interactions mediated by Notch and Delta which may function as receptor and ligand (signal), respectively, in a lateral signalling pathway. The cells of a group are equipotential and express both Notch and Delta. Hyperactive mutant Notch molecules, (Abruptex), probably have an enhanced affinity for the ligand. When adjacent to wild-type cells, cells bearing the Abruptex proteins are unable to produce the signal. It is suggested that in addition to the binding of Notch molecules on one cell to the Delta molecules of opposing cells, the Notch and Delta proteins on the surface of the same cell may interact. Binding between a cell's own Notch and Delta molecules would alter the availability of these proteins to interact with their counterparts on adjacent cells.

REFERENCES

    1. Andrews B. J.,
    2. Herskowitz I.
    (1989) The yeast SW14 protein contains a motif present in developmental regulators and is part of a complex involved in cell-cyle dependant transcription. Nature 342, 830–833
    OpenUrlCrossRefPubMed
    1. Boulianne G. L.,
    2. de la Concha A.,
    3. Campos-Ortega J.,
    4. Jan L. Y.,
    5. Jan Y. N.
    (1991) The Drosophila neurogenic gene neuralised encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J 10, 2975–2983
    OpenUrlPubMedWeb of Science
    1. Cubas P.,
    2. de Celis J.-F.,
    3. Campuzano S.,
    4. Modolell J.
    (1991) Proneural clusters of achaete/scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev 5, 996–1008
    OpenUrlAbstract/FREE Full Text
    1. Coffman C.,
    2. Harris W.,
    3. Kintner C.
    (1990) Xotch, the Xenopus homolog of Drosophila Notch. Sci 249, 1438–1441
    OpenUrlAbstract/FREE Full Text
    1. Doe C. Q.,
    2. Goodman C. S.
    (1985) Early events in insect neurogenesis. II. Role of cell interactions and cell lineage in the determination of neuronal precursor cells. Dev. Biol 111, 206–219
    OpenUrlCrossRefPubMedWeb of Science
    1. Ellisen L. W.,
    2. Bird J.,
    3. West D. C.,
    4. Lee Soreng A.,
    5. Reynolds T. C.,
    6. Smith S. D.,
    7. Sklar J.
    (1991) TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649–661
    OpenUrlCrossRefPubMedWeb of Science
    1. Fehon R. G.,
    2. Johansen K.,
    3. Rebay I.,
    4. Artavanis-Tsakonas S.
    (1991) Complex cellular and subcellular regulation of Notch expression during embryonic and imaginal development of Drosophila: implications for Notch function. J. Cell Biol 113, 657–669
    OpenUrlAbstract/FREE Full Text
    1. Fehon R. G.,
    2. Kooh P. J.,
    3. Rebay I.,
    4. Regan C. L.,
    5. Xu T.,
    6. Muskavitch M. A. T.,
    7. Artavanis-Tsakonas S.
    (1990) Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61, 523–534
    OpenUrlCrossRefPubMedWeb of Science
    1. Foster G. G.
    (1975) Negative complementation at the Notch locus of Drosophila melanogaster. Genetics 81, 99–120
    OpenUrlAbstract/FREE Full Text
    1. Garcia-Bellido A.
    (1979) Genetic analysis of the achaete-scute system of Drosophila melanogaster. Genetics 91, 491–520
    OpenUrlAbstract/FREE Full Text
    1. Garcia-Bellido A.,
    2. Santamaria P.
    (1978) Developmental analysis of the achaete-scute system of Drosophila melanogaster. Genetics 88, 469–486
    OpenUrlAbstract/FREE Full Text
    1. Ghysen A.,
    2. Dambly-Chaudiere C.
    (1988) From DNA to form: the achaete-scute complex. Genes Dev 2, 495–501
    OpenUrlFREE Full Text
    1. Goriely A.,
    2. Dumont N.,
    3. Dambly-Chaudiere C.,
    4. Ghysen A.
    (1991) The determination of sense organs in Drosophila: effect of the neurogenic mutations in the embryo. Development 113, 1395–1404
    OpenUrlAbstract
    1. Greenwald I.,
    2. Rubin G.
    (1992) Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68, 271–281
    OpenUrlCrossRefPubMedWeb of Science
    1. Greenwald I.,
    2. Seydoux G.
    (1990) Analysis of gain of function mutations of the lin-12 gene of Caenorhabditis elegans. Nature 346, 197–199
    OpenUrlCrossRefPubMed
    1. Hartenstein V.,
    2. Posakony J. W.
    (1989) Development of adult sensilla on the wing and notum of Drosophila melanogaster. Development 107, 389–405
    OpenUrlAbstract
    1. Hartenstein V.,
    2. Posakony J. W.
    (1990) A dual function of the Notch gene in Drosophila sensillum development. Dev. Biol 142, 13–30
    OpenUrlCrossRefPubMedWeb of Science
    1. Hartley D.,
    2. Xu T.,
    3. Artavanis-Tsakonas S.
    (1987) The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein. EMBO J 6, 3407–3417
    OpenUrlPubMedWeb of Science
    1. Haskill S.,
    2. Beg A. A.,
    3. Tompkins S. M.,
    4. Morris J. S.,
    5. Yuochko A. D.,
    6. Sampson-Johannes A.,
    7. Mondal K.,
    8. Ralph P.,
    9. Baldwin A. S., Jr.
    (1991) Characterisation of an immediate early gene induced in adherent monocytes that encodes IkB-like activity. Cell 65, 1281–1289
    OpenUrlCrossRefPubMedWeb of Science
    1. Hoppe P. E.,
    2. Greenspan R. J.
    (1986) Local function of the Notch gene for embryonic ectodermal pathway choice in Drosophila. Cell 46, 773–783
    OpenUrlCrossRefPubMedWeb of Science
    1. Horvitz H. R.,
    2. Sternberg P. W.
    (1991) Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva. Nature 351, 535–541
    OpenUrlCrossRefPubMedWeb of Science
    1. Kelley M. R.,
    2. Kidd S.,
    3. Deutsch W. A.,
    4. Young M. W.
    (1987) Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus. Cell 51, 539–548
    OpenUrlCrossRefPubMedWeb of Science
    1. Kidd S.,
    2. Kelley M. R.,
    3. Young M. W.
    (1986) Sequence of the Notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Mol. Cell Biol 6, 3094–3108
    OpenUrlAbstract/FREE Full Text
    1. Kidd S.,
    2. Baylies M. K.,
    3. Gasic G. P.,
    4. Young M. W.
    (1989) Structure and distribution of the Notch protein in developing Drosophila. Genes Dev 3, 1113–1129
    OpenUrlAbstract/FREE Full Text
    1. Kopczynski C. C.,
    2. Alton A. K.,
    3. Fechtel K.,
    4. Kooh P. J.,
    5. Muskavitch M. A. T.
    (1988) Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. Genes Dev 2, 1723–1735
    OpenUrlAbstract/FREE Full Text
    1. Lux S. E.,
    2. John K. M.,
    3. Bennett V.
    (1990) Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell cycle control proteins. Nature 344, 36–42
    OpenUrlCrossRefPubMedWeb of Science
    1. Mitchell H. K.,
    2. Edens J.,
    3. Petersen N. S.
    (1990) Stages of hair construction in Drosophila. Dev. Genet 11, 133–140
    OpenUrlCrossRefPubMed
    1. Palka J.,
    2. Scubiger M.,
    3. Schwanniger H.
    (1990) Neurogenic and antineurogenic effects from modifications at the Notch locus. Development 109, 167–175
    OpenUrlAbstract
    1. Portin P.
    (1975) Allelic negative complementation at the Abruptex locus of Drosophila melanogaster. Genetics 81, 121–133
    OpenUrlAbstract/FREE Full Text
    1. Portin P.
    (1981) The antimorphic mode of action of lethal Abruptex alleles of the Notch locus in Drosophila melanogaster. Hereditas 95, 247–251
    OpenUrl
    1. Ramos R. G. P.,
    2. Grimwade B. G.,
    3. Wharton K. A.,
    4. Scottgale T. N.,
    5. Artavanis-Tsakonas S.
    (1989) Physical and functional definition of the Drosophila Notch locus by P element transformation. Genetics 123, 337–348
    OpenUrlAbstract/FREE Full Text
    1. Rebay I.,
    2. Fleming R. J.,
    3. Fehon R. G.,
    4. Cherbas L.,
    5. Cherbas P.,
    6. Artavanis-Tsakonas S.
    (1991) Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor. Cell 67, 687–699
    OpenUrlCrossRefPubMedWeb of Science
    1. Rubin G. M.
    (1991) Signal transduction and the fate of the R7 photoreceptor in Drosophila. Trends Genet 7, 372–377
    OpenUrlCrossRefPubMedWeb of Science
    1. Simpson P.
    (1990) Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. Development 109, 509–519
    OpenUrlAbstract
    1. Simpson P.,
    2. Carteret C.
    (1990) Proneural clusters: equivalence groups in the epithelium of Drosophila. Development 110, 927–932
    OpenUrlAbstract/FREE Full Text
    1. Skeath J. B.,
    2. Caroll S. B.
    (1991) Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev 5, 984–995
    OpenUrlAbstract/FREE Full Text
    1. Stern C.
    (1954) Two or three bristles. Am. Scientist 42, 213–247
    OpenUrl
    1. Thompson C. C.,
    2. Brown T. A.,
    3. McKnight S. L.
    (1991) Convergence of Ets-and Notch-related structural motifs in a heteromeric DNA binding complex. Science 253, 762–768
    OpenUrlAbstract/FREE Full Text
    1. Vässin H.,
    2. Bremer K. A.,
    3. Knust E.,
    4. Campos-Ortega J. A.
    (1987) The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J 6, 3433–3440
    OpenUrl
    1. Weinmaster G.,
    2. Roberts V. J.,
    3. Lemke G.
    (1991) A homolog of DrosophilaNotch expressed during mammalian development. Development 113, 199–205
    OpenUrlAbstract
    1. Welshons W. J.
    (1971) Genetic basis for two types of recessive lethality at the Notch locus of Drosophila. Genetics 68, 259–268
    OpenUrlFREE Full Text
    1. Wharton K. A.,
    2. Johansen K. M.,
    3. Xu T.,
    4. Artavanis-Tsakonas S.
    (1985) Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43, 567–581
    OpenUrlCrossRefPubMedWeb of Science
    1. Wigglesworth V. B.
    (1940) Local and general factors in the development of ‘pattern' in Rhodnius prolixus (Hemiptera). J. Exp. Biol 17, 180–200
    OpenUrlAbstract
    1. Xu T.,
    2. Rebay I.,
    3. Fleming R. J.,
    4. Scotgale T. N.,
    5. Artavanis-Tsakonas S.
    (1990) The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev 4, 464–475
    OpenUrlAbstract/FREE Full Text
    1. Xu T.,
    2. Caron L.,
    3. Fehon R.,
    4. Artavanis-Tsakonas S.
    (1992) The involvement of the Notch locus in Drosophila oogenesis. Development 115, 913–922
    OpenUrlAbstract
    1. Yochem J.,
    2. Weston K.,
    3. Greenwald I.
    (1988) The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Nature 335, 547–550
    OpenUrlCrossRefPubMed
    1. Yochem J.,
    2. Greenwald I.
    (1989) glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins. Cell 58, 553–563
    OpenUrlCrossRefPubMedWeb of Science
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JOURNAL ARTICLES
Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions
P. Heitzler, P. Simpson
Development 1993 117: 1113-1123;
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