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JOURNAL ARTICLES
Segmental repetition of neuronal phenotype sets in the chick embryo hindbrain
J.D. Clarke, A. Lumsden
Development 1993 118: 151-162;

Summary

The neurons within the segmented hindbrain of the early chick embryo have been mapped with the neuronal tracers HRP and fluorescent lysinated dextran. We have categorised neurons according to their axonal pathways and have then compared rhombomeres with respect to the number and class of neurons present. The results indicate that most rhombomeres are similar in that they contain the same set of basic neuronal types but differ in that particular neuronal types are more abundant in some rhombomeres than others. The data support the concept that the hindbrain develops according to ‘variations on a segmental theme’ rather than ‘each segment is unique’. Many of the cell types occupy distinct mediolateral domains that are probably established by both the differential migration of some neuronal classes and the spatial segregation of distinct precursors. The caudal rhombomeres 7 and 8 are exceptional in that they do not have the full set of basic neuronal types and also contain two additional medial cell types that are not present rostrally. The mechanisms that may generate the regional diversity apparent in the more mature hindbrain are discussed.

Reference

    1. Burns F. R.,
    2. von Kannen S.,
    3. Guy L.,
    4. Raper J. A.,
    5. Kamholz J.,
    6. Chang S.
    (1991) DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension. Neuron 7, 209–220
    OpenUrlCrossRefPubMedWeb of Science
    1. Doe C. Q.,
    2. Goodman C. S.
    (1985) Early events in insect neurogenesis. The role of cell interactions and cell lineage in the determination of neuronal precursor cells. Dev. Biol 111, 206–219
    OpenUrlCrossRefPubMedWeb of Science
    1. Fraser S.,
    2. Keynes R.,
    3. Lumsden A.
    (1990) Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions. Nature 344, 431–435
    OpenUrlCrossRefPubMed
    1. Glover J. C.,
    2. Petursdottir G.
    (1988) Pathway specificity of reticulospinal and vestibulospinal projections in the 11-day chicken embryo. J. Comp. Neurol 270, 25–38
    OpenUrlCrossRefPubMedWeb of Science
    1. Glover J. C.,
    2. Petursdottir G.
    (1991) Regional specificity ofdeveloping reticulospinal, vestibulospinal and vestibulo-ocular projections in the chicken embryo. J. Neurobiol 22, 352–376
    OpenUrl
    1. Guthrie S.,
    2. Lumsden A.
    (1992) Motor neuron pathfinding following rhombomere reversals in the chick hindbrain. Development 114, 663–673
    OpenUrlAbstract
    1. Hannemann E.,
    2. Trevarrow B.,
    3. Metcalfe W. K.,
    4. Kimmel C. B.,
    5. Westerfield M.
    (1988) Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo. Development 103, 49–58
    OpenUrlAbstract
    1. Holt C. E.,
    2. Bertsch T. W.,
    3. Ellis H. M.,
    4. Harris W. A.
    (1988) Cellular determination in the Xenopus retina is independent of lineage and birth date. Neuron 1, 15–26
    OpenUrlCrossRefPubMedWeb of Science
    1. Kimmel C. B.,
    2. Powell S. L.,
    3. Metcalfe W. K.
    (1982) Brain neurons which project to the spinal cord in young larvae of the zebrafish. J. Comp. Neurol 205, 112–127
    OpenUrlCrossRefPubMedWeb of Science
    1. Kuwada J. Y.,
    2. Goodman C. S.
    (1985) Neuronal determination during embryonic development of the grasshopper nervous system. Dev. Biol 110, 114–126
    OpenUrlCrossRefPubMedWeb of Science
    1. Lumsden A.
    (1990) The cellular basis of segmentation in the developing hindbrain. Trends Neurosci 13, 329–335
    OpenUrlCrossRefPubMedWeb of Science
    1. Lumsden A.,
    2. Keynes R.
    (1989) Segmental patterns of neuronal development in the chick hindbrain. Nature 337, 424–428
    OpenUrlCrossRefPubMed
    1. Marshall H.,
    2. Nonchev S.,
    3. Sham M.H.,
    4. Muchamore I.,
    5. Lumsden A.,
    6. Krumlauf R.
    (1992) Retinoic acid alters the hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Nature 360, 737–741
    OpenUrlCrossRefPubMed
    1. McConnell S. K.,
    2. Kaznowski C. E.
    (1991) Cell cycle dependence of laminar determination in developing neocortex. Science 254, 282–285
    OpenUrlAbstract/FREE Full Text
    1. Mendelson B.
    (1986) Development of reticulospinal neurons of the zebrafish. I. Time of origin. J. Comp. Neurol 251, 160–171
    OpenUrlCrossRefPubMedWeb of Science
    1. Mendelson B.
    (1986) Development of reticulospinal neurons of the zebrafish. II. Early axonal outgrowth and cell body position. J. Comp. Neurol 251, 172–184
    OpenUrlCrossRefPubMedWeb of Science
    1. Metcalfe W. K.,
    2. Mendelson B.,
    3. Kimmel C. B.
    (1986) Segmental homologies among reticulospinal neurons in the hindbrain of the zebrafish larvae. J. Comp. Neurol 251, 147–159
    OpenUrlCrossRefPubMedWeb of Science
    1. Moody S. A.,
    2. Heaton M. B.
    (1981) Morphology of migrating trigeminal neuroblasts as revealed by horseradish peroxidase retrograde labelling techniques. Neuroscience 6, 1707–1723
    OpenUrlCrossRefPubMedWeb of Science
    1. Nordlander R. H.,
    2. Baden S. T.,
    3. Ryba T. M. J.
    (1985) Development of early brainstem projections to the tail spinal cord in Xenopus. J. Comp. Neurol 231, 519–529
    OpenUrlCrossRefPubMedWeb of Science
    1. Petursdottir G.
    (1990) Vestibulo-ocular projections in the 11-day chicken embryo: pathway specificity. J. Comp. Neurol 297, 283–297
    OpenUrlCrossRefPubMedWeb of Science
    1. Rovainen C.
    (1967) Physiological and anatomical studies on large neurons of the central nervous system of the sea lamprey (Petromyzon marinus) Muller and Mauthner cells. J. Neurophysiol 30, 1024–1042
    OpenUrlFREE Full Text
    1. Trevarrow B.,
    2. Marks D. L.,
    3. Kimmel C. B.
    (1990) Organisation of hindbrain segments in the zebrafish embryo. Neuron 4, 669–679
    OpenUrlCrossRefPubMedWeb of Science
    1. Van Mier P.,
    2. ten Donkelaar H. J.
    (1984) Early development of the descending pathways from the brain stem to the spinal cord in Xenopus laevis. Anat. Embryol 170, 259–306
    OpenUrl
    1. Walsh C.,
    2. Cepko C. L.
    (1992) Widespread dispersion of neuronal clones across functional regions of the cerebral cortex. Science 255, 434–440
    OpenUrlAbstract/FREE Full Text
    1. Wetts R.,
    2. Fraser S. E.
    (1988) Multipotent precursors can give rise to all major cell groups of the frog retina. Science 239, 1142–1145
    OpenUrlAbstract/FREE Full Text
    1. Windle W. F.,
    2. Austin M. F.
    (1936) Neurofibrillar development in the central nervous system of chick embryos up to 5 days incubation. J. Comp. Neurol 63, 431–463
    OpenUrlCrossRef
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JOURNAL ARTICLES
Segmental repetition of neuronal phenotype sets in the chick embryo hindbrain
J.D. Clarke, A. Lumsden
Development 1993 118: 151-162;
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