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JOURNAL ARTICLES
Cell fate specification by even-skipped expression in the Drosophila nervous system is coupled to cell cycle progression
K. Weigmann, C.F. Lehner
Development 1995 121: 3713-3721;

Summary

The correct specification of defined neurons in the Drosophila central nervous system is dependent on even-skipped. During CNS development, even-skipped expression starts in the ganglion mother cell resulting from the first asymmetric division of neuroblast NB 1–1. This first division of NB 1–1 (and of the other early neuroblasts as well) is temporally controlled by the transcriptional regulation of string expression, which we have manipulated experimentally, even-skipped expression still occurs if the first neuroblast division is delayed, but not if the division is prohibited. Moreover, even-skipped expression is also dependent on progression through S phase which follows immediately after the first division. However, cytokinesis during the first NB division is not required for even-skipped expression as revealed by observations in pebble mutant embryos. Our results demonstrate therefore that even-skipped expression is coupled to cell cycle progression, presumably in order to prevent a premature activation of expression by a positive regulator which is produced already in the neuroblast during G2 and segregated asymmetrically into the ganglion mother cell during mitosis.

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JOURNAL ARTICLES
Cell fate specification by even-skipped expression in the Drosophila nervous system is coupled to cell cycle progression
K. Weigmann, C.F. Lehner
Development 1995 121: 3713-3721;
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