Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in
  • Log out

Search

  • Advanced search
Development
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Development

  • Log in
Advanced search

RSS  Twitter  Facebook  YouTube 

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
JOURNAL ARTICLES
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
F.J. Diaz-Benjumea, S.M. Cohen
Development 1995 121: 4215-4225;
F.J. Diaz-Benjumea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.M. Cohen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & metrics
  • PDF
Loading

Summary

Growth and patterning of the Drosophila wing is controlled by organizing centers located at the anterior-posterior and dorsal-ventral compartment boundaries. Interaction between cells in adjacent compartments establish the organizer. We report here that Serrate and Notch mediate the interaction between dorsal and ventral cells to direct localized expression of Wingless at the D/V boundary. Serrate serves as a spatially localized ligand which directs Wg expression through activation of Notch. Ligand independent activation of Notch is sufficient to direct Wg expression, which in turn mediates the organizing activity of the D/V boundary.

Reference

    1. Artavanis-Tsakonas S.,
    2. Matsuno K.,
    3. Fortini M.
    (1995) Notch signaling. Science 268, 225–232
    OpenUrlAbstract/FREE Full Text
    1. Baker N. E.
    (1988) Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila and the phenotype of a pupal lethal wg mutation. Development 102, 489–497
    OpenUrlAbstract
    1. Baker N. E.
    (1988) Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila. Dev. Biol 125, 96–108
    OpenUrlCrossRefPubMedWeb of Science
    1. Bang A. G.,
    2. Hartenstein V.,
    3. Posakony J. W.
    (1991) Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Development 111, 89–104
    OpenUrlAbstract
    1. Basler K.,
    2. Struhl G.
    (1994) Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208–214
    OpenUrlCrossRefPubMedWeb of Science
    1. Blair S. S.
    (1992) shaggy (zeste-white 3) and the formation of supernumerary Bristle precursors in the developing wing blade of Drosophila. Dev. Biol 152, 263–278
    OpenUrlCrossRefPubMedWeb of Science
    1. Blair S. S.
    (1993) Mechanisms of compartment formation: Evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila. Development 119, 339–351
    OpenUrlAbstract
    1. Blair S. S.,
    2. Brower D. L.,
    3. Thomas J. B.,
    4. Zavortink M.
    (1994) The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. Development 120, 1805–1815
    OpenUrlAbstract
    1. Campbell G.,
    2. Weaver T.,
    3. Tomlinson A.
    (1993) Axis specification in the developing Drosophila appendage: the role of wingless, decapentaplegic, and the homeobox gene aristaless. Cell 74, 1113–1123
    OpenUrlCrossRefPubMedWeb of Science
    1. Capdevila J.,
    2. Guerrero I.
    (1994) Targeted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alerations in Drosophila wings. EMBO J 13, 4459–4468
    OpenUrlPubMedWeb of Science
    1. Castelli-Gair J.,
    2. Muller J.,
    3. Bienz M.
    (1992) Function of an Ultrabithorax minigene in imaginal cells. Development 114, 877–886
    OpenUrlAbstract
    1. Coffman C. R.,
    2. Skoglund P.,
    3. Harris W. A.,
    4. Kintner C. R.
    (1993) Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell 73, 659–671
    OpenUrlCrossRefPubMedWeb of Science
    1. Cohen B.,
    2. McGuffin M. E.,
    3. Pfeifle C.,
    4. Segal D.,
    5. Cohen S. M.
    (1992) apterous: a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins. Genes Dev 6, 715–729
    OpenUrlAbstract/FREE Full Text
    1. Couso J. P.,
    2. Bate M.,
    3. Martinez Arias A.
    (1993) A wingless- dependent polar coordinate system in the imaginal discs of Drosophila. Science 259, 484–489
    OpenUrlAbstract/FREE Full Text
    1. Couso J. P.,
    2. Bishop S.,
    3. Martinez Arias A.
    (1994) The wingless signalling pathway and the patterning of the wing margin in Drosophila. Development 120, 621–636
    OpenUrlAbstract
    1. Couso J. P.,
    2. Martinez Arias A.
    (1994) Notch is required for wingless signalling in the epidermis of Drosophila. Cell 79, 259–272
    OpenUrlCrossRefPubMedWeb of Science
    1. De Celis J. F.,
    2. Garcia Bellido A.
    (1994) Roles of the Notch gene in Drosophila wing morphogenesis. Mech. Dev 46, 109–122
    OpenUrlCrossRefPubMedWeb of Science
    1. Diaz-Benjumea F. J.,
    2. Cohen S. M.
    (1993) Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila. Cell 75, 741–752
    OpenUrlCrossRefPubMedWeb of Science
    1. Diaz-Benjumea F. J.,
    2. Cohen S. M.
    (1994) wingless acts through the shaggy/zeste-white 3 kinase to direct dorsal-ventral axis formation in the Drosophila leg. Development 120, 1661–1670
    OpenUrlAbstract
    1. Diaz-Benjumea F. J.,
    2. Cohen B.,
    3. Cohen S. M.
    (1994) Cell interactions between compartments establishes the proximal-distal axis of Drosophila limbs. Nature 372, 175–179
    OpenUrlCrossRefPubMed
    1. Fleming R. J.,
    2. Scottgale T. N.,
    3. Diederich R. J.,
    4. Artavanis-Tsakonas S.
    (1990) The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev 4, 2188–2201
    OpenUrlAbstract/FREE Full Text
    1. Fortini M. E.,
    2. Artavanis-Tsakonas S.
    (1994) The suppressor of hairless protein participates in Notch receptor signalling. Cell 79, 273–282
    OpenUrlCrossRefPubMedWeb of Science
    1. Fortini M. E.,
    2. Rebay I.,
    3. Caron L. A.,
    4. Artavanis-Tsakonas S.
    (1993) An activated Notch receptor blocks cell fate commitment in the developing Drosophila eye. Nature 365, 555–557
    OpenUrlCrossRefPubMedWeb of Science
    1. García-Bellido A.,
    2. Ripoll P.,
    3. Morata G.
    (1973) Developmental compartmentalisation of the wing disk of Drosophila. Nature New Biol 245, 251–253
    OpenUrlCrossRefPubMedWeb of Science
    1. González-Gaitán M.,
    2. Paz Capdevila M.,
    3. García-Bellido A.
    (1994) Cell proliferation patterns in the wing imaginal disc of Drosophila. Mech. Dev 40, 183–200
    1. Greenwald I.,
    2. Rubin G.
    (1992) Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68, 271–281
    OpenUrlCrossRefPubMedWeb of Science
    1. Heitzler P.,
    2. Simpson P.
    (1991) The choice of cell fate in the epidermis of Drosophila. Cell 64, 1083–1092
    OpenUrlCrossRefPubMedWeb of Science
    1. Henderson S. T.,
    2. Gao D.,
    3. Lambie E. J.,
    4. Kimble J.
    (1994) lag-2 may encode a signaling ligand for the GLP-1 and LIN12 receptors of C. elegans. Development 120, 2913–2924
    OpenUrlAbstract
    1. Hing H. K.,
    2. Sun X.,
    3. Artavanis-Tsakonas S.
    (1994) Modulation of wingless signaling by Notch in Drosophila. Mech. Dev 47, 261–268
    OpenUrlCrossRefPubMedWeb of Science
    1. Hooper J.
    (1994) Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature 372, 461–464
    OpenUrlCrossRefPubMedWeb of Science
    1. Ingham P. W.
    (1993) Localized hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo. Nature 366, 560–562
    OpenUrlCrossRefPubMedWeb of Science
    1. Ingham P. W.,
    2. Fietz M. J.
    (1995) Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. Curr. Biol 5, 432–440
    OpenUrlCrossRefPubMedWeb of Science
    1. Ingham P. W.,
    2. Taylor A. M.,
    3. Nakano Y.
    (1991) Role of the Drosophila patched gene in positional signalling. Nature 353, 184–187
    OpenUrlCrossRefPubMedWeb of Science
    1. Irvine K.,
    2. Wieschaus E.
    (1994) fringe, a boundary specific signalling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79, 595–606
    OpenUrlCrossRefPubMedWeb of Science
    1. Jiang J.,
    2. Struhl G.
    (1995) Protein kinase A and Hedgehog signaling in Drosophila limb development. Cell 80, 563–572
    OpenUrlCrossRefPubMedWeb of Science
    1. Lawrence P. A.,
    2. Morata G.
    (1994) Homeobox genes: their function in Drosophila segmentation and pattern formation. Cell 78, 181–189
    OpenUrlCrossRefPubMedWeb of Science
    1. Lee J. J.,
    2. von Kessler D. P.,
    3. Parks S.,
    4. Beachy P. A.
    (1992) Secretionand localized transcript suggest a role in positional signalling for products of the segmentation gene hedgehog. Cell 71, 33–50
    OpenUrlCrossRefPubMedWeb of Science
    1. Lepage T.,
    2. Cohen S. M.,
    3. Diaz-Benjumea F. J.,
    4. Parkhurst S. M.
    (1995) Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711–715
    OpenUrlCrossRefPubMedWeb of Science
    1. Li W.,
    2. Ohlmeyer J. T.,
    3. Lane M. E.,
    4. Kalderon D.
    (1995) Function of protein kinase A in Hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553–562
    OpenUrlCrossRefPubMedWeb of Science
    1. Maves L.,
    2. Schubiger G.
    (1995) wingless induces transdetermination in developing Drosophila imaginal discs. Development 121, 1263–1272
    OpenUrlAbstract
    1. Mohler J.
    (1988) Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 120, 1061–1072
    OpenUrlAbstract/FREE Full Text
    1. Mohler J.,
    2. Vani K.
    (1992) Molecular organisation and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115, 957–971
    OpenUrlAbstract
    1. Morata G.,
    2. Ripoll P.
    (1975) Minutes: mutants of drosophila autonomously affecting cell division rate. Dev. Biol 42, 211–221
    OpenUrlCrossRefPubMedWeb of Science
    1. Ng M.,
    2. Diaz-Benjumea F. J.,
    3. Cohen S. M.
    (1995) nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing. Development 121, 589–599
    OpenUrlAbstract
    1. Niswander L.,
    2. Martin G. R.
    (1993) FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361, 68–71
    OpenUrlCrossRefPubMed
    1. Niswander L.,
    2. Tickle C.,
    3. Vogel A.,
    4. Booth I.,
    5. Martin G. R.
    (1993) FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579–587
    OpenUrlCrossRefPubMedWeb of Science
    1. Pan D. J.,
    2. Rubin G.
    (1995) Protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543–552
    OpenUrlCrossRefPubMedWeb of Science
    1. Perrimon N.,
    2. Smouse D.
    (1989) Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis. Dev. Biol 135, 287–305
    OpenUrlCrossRefPubMed
    1. Phillips R.,
    2. Whittle R.
    (1993) wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development. Development 118, 427–438
    OpenUrlAbstract
    1. Rebay I.,
    2. Fehon R. G.,
    3. Artavanis-Tsakonas S.
    (1993) Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74, 319–329
    OpenUrlCrossRefPubMedWeb of Science
    1. Rebay I.,
    2. Fleming R. J.,
    3. Fehon R. G.,
    4. Cherbas L.,
    5. Cherbas P.,
    6. Artavanis-Tsakonas S.
    (1991) Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67, 687–699
    OpenUrlCrossRefPubMedWeb of Science
    1. Ruel L.,
    2. Pantesco V.,
    3. Lutz Y.,
    4. Simpson P.,
    5. Bourouis M.
    (1993) Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila. EMBO J 12, 1657–1669
    OpenUrlPubMedWeb of Science
    1. Sanicola M.,
    2. Sekelsky J. S. E.,
    3. Gelbart W. M.
    (1995) Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139, 745–756
    OpenUrlAbstract/FREE Full Text
    1. Schallenberger D. L.,
    2. Mohler J. D.
    (1978) Temperature sensitive periods and autonomy of pleiotropic effects of l(1)N ts, a conditional Notch lethal in Drosophila. Dev. Biol 62, 432–446
    OpenUrlCrossRefPubMedWeb of Science
    1. Schweisguth F.
    (1995) Suppressor of Hairless is required for signal receptionduring lateral inhibition in the Drosophila pupal notum. Development 121, 1875–1884
    OpenUrlAbstract
    1. Siegfried E.,
    2. Chou T.-B.,
    3. Perrimon N.
    (1992) wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell 71, 1167–1179
    OpenUrlCrossRefPubMedWeb of Science
    1. Simpson P.,
    2. El Messal M.,
    3. Moscoso del Prado J.,
    4. Ripoll P.
    (1988) Stripes of positional homologies across the wing blade of Drosophila melanogaster. Development 103, 391–401
    OpenUrlAbstract
    1. Speicher S. A.,
    2. Thomas U.,
    3. Hinz U.,
    4. Knust E.
    (1994) The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development 120, 535–544
    OpenUrlAbstract
    1. Struhl G.,
    2. Basler K.
    (1993) Organizing activity of wingless protein in Drosophila. Cell 72, 527–540
    OpenUrlCrossRefPubMedWeb of Science
    1. Struhl G.,
    2. Fitzgerald K.,
    3. Greenwald I.
    (1993) Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331–345
    OpenUrlCrossRefPubMedWeb of Science
    1. Tabata T.,
    2. Eaton S.,
    3. Kornberg T. B.
    (1992) The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev 6, 2635–2645
    OpenUrlAbstract/FREE Full Text
    1. Tabata T.,
    2. Kornberg T.
    (1994) Hedgehog is a signalling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89–102
    OpenUrlCrossRefPubMedWeb of Science
    1. Thomas U.,
    2. Jönsson F.,
    3. Speicher S. A.,
    4. Knust E.
    (1995) Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate. Genetics 139, 203–213
    OpenUrlAbstract/FREE Full Text
    1. Thomas U.,
    2. Speicher S. A.,
    3. Knust E.
    (1991) The Drosophila gene Serrate encodes an EGF-like transmembrane protein with complex expression patterns in embryos and wing discs. Development 111, 749–761
    OpenUrlAbstract
    1. Vachon G.,
    2. Cohen B.,
    3. Pfeifle C.,
    4. McGuffin M. E.,
    5. Botas J.,
    6. Cohen S. M.
    (1992) Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell 71, 437–450
    OpenUrlCrossRefPubMedWeb of Science
    1. van den Heuvel M.,
    2. Nusse R.,
    3. Johnston P.,
    4. Lawrence P. A.
    (1989) Distribution of the wingless gene product in Drosophila embryos: A protein involved in cell-cell communication. Cell 59, 739–749
    OpenUrlCrossRefPubMedWeb of Science
    1. Williams J. A.,
    2. Paddock S. W.,
    3. Carroll S. B.
    (1993) Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. Development 117, 571–584
    OpenUrlAbstract
    1. Williams J. A.,
    2. Paddock S. W.,
    3. Vorwerk K.,
    4. Carroll S. B.
    (1994) Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary. Nature 368, 299–305
    OpenUrlCrossRefPubMed
    1. Zecca M.,
    2. Basler K.,
    3. Struhl G.
    (1995) Sequential organizing activities of engrailed hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265–2278
    OpenUrlAbstract
Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

 Download PDF

Email

Thank you for your interest in spreading the word on Development.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
(Your Name) has sent you a message from Development
(Your Name) thought you would like to see the Development web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
JOURNAL ARTICLES
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
F.J. Diaz-Benjumea, S.M. Cohen
Development 1995 121: 4215-4225;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
JOURNAL ARTICLES
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
F.J. Diaz-Benjumea, S.M. Cohen
Development 1995 121: 4215-4225;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
  • Info & metrics
  • PDF

Related articles

Cited by...

More in this TOC section

  • A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development
  • Visualization and functional characterization of the developing murine cardiac conduction system
  • Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
Show more JOURNAL ARTICLES

Similar articles

Other journals from The Company of Biologists

Journal of Cell Science

Journal of Experimental Biology

Disease Models & Mechanisms

Biology Open

Advertisement

Kathryn Virginia Anderson (1952-2020)

Developmental geneticist Kathryn Anderson passed away at home on 30 November 2020. Tamara Caspary, a former postdoc and friend, remembers Kathryn and her remarkable contribution to developmental biology.


Zooming into 2021

In a new Editorial, Editor-in-Chief James Briscoe and Executive Editor Katherine Brown reflect on the triumphs and tribulations of the last 12 months, and look towards a hopefully calmer and more predictable year.


Read & Publish participation extends worldwide

Over 60 institutions in 12 countries are now participating in our Read & Publish initiative. Here, James Briscoe explains what this means for his institution, The Francis Crick Institute. Find out more and view our full list of participating institutions.


Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.


Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Sign up to join our next session:

10 February
Time: 13:00 (GMT)
Chaired by: preLights

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Sign up for alerts

About us

  • About Development
  • About the Node
  • Editors and board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact Development
  • Subscriptions
  • Advertising
  • Feedback

 Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992