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JOURNAL ARTICLES
Homeobox genes and connective tissue patterning
G. Oliver, R. Wehr, N.A. Jenkins, N.G. Copeland, B.N. Cheyette, V. Hartenstein, S.L. Zipursky, P. Gruss
Development 1995 121: 693-705;
G. Oliver
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R. Wehr
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N.A. Jenkins
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N.G. Copeland
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B.N. Cheyette
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V. Hartenstein
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S.L. Zipursky
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P. Gruss
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Summary

In vertebrates, limb tendons are derived from cells that migrate from the lateral plate mesoderm during early development. While some of the developmental steps leading to the formation of these tissues are known, little is known about the molecular mechanisms controlling them. We have identified two murine homeobox-containing genes, Six 1 and Six 2, which are expressed in a complementary fashion during the development of limb tendons. Transcripts for both genes are found in different sets of phalangeal tendons. Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes.

Reference

    1. Auffray C.,
    2. Rougeon F.
    (1980) Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur. J. Biochem 107, 303–314
    OpenUrlPubMedWeb of Science
    1. Bober E.,
    2. Franz T.,
    3. Arnold H. H.,
    4. Gruss P.,
    5. Tremblay P.
    (1994) Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development 120, 603–612
    OpenUrlAbstract
    1. Butler J.,
    2. Cosmos E.,
    3. Cauwenbergs P. C.
    (1988) Positional signals: evidence for a possible role in muscle fibre-type patterning of the embryonic avian limb. Development 102, 763–772
    OpenUrlAbstract/FREE Full Text
    1. Cheyette B. N. R.,
    2. Green P. J.,
    3. Martin K.,
    4. Garren H.,
    5. Hartenstein V.,
    6. Zipursky S. L.
    (1994) The Drosophilasineoculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12, 977–996
    OpenUrlCrossRefPubMedWeb of Science
    1. Copeland N. G.,
    2. Jenkins N. A.
    (1991) Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet 7, 113–118
    OpenUrlPubMedWeb of Science
    1. Fishel R.,
    2. Lescoe M. K.,
    3. Rao M. R. S.,
    4. Copeland N. G.,
    5. Jenkins N. A.,
    6. Garber J.,
    7. Kane M.,
    8. Kolodner R.
    (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 1027–1038
    OpenUrlCrossRefPubMedWeb of Science
    1. Frohman M. A.,
    2. Dush M. K.,
    3. Martin G. R.
    (1988) Rapid production of full-length cDNAs from rare transcripts amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85, 8998–9002
    OpenUrlAbstract/FREE Full Text
    1. Hurle J. M.,
    2. Ros M. A.,
    3. Ganan Y.,
    4. Macias D.,
    5. Critchlow M.,
    6. Hinchliffe J. R.
    (1990) Experimental analysis of the role of ECM in the patterning of the distal tendons of the developing limb bud. Cell Differ. Dev 30, 97–108
    OpenUrlCrossRefPubMedWeb of Science
    1. Jenkins N. A.,
    2. Copeland N. G.,
    3. Taylor B. A.,
    4. Lee B. K.
    (1982) Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomed of Mus musculus. J. Virol 43, 26–36
    OpenUrlAbstract/FREE Full Text
    1. Kessel M.,
    2. Gruss P.
    (1991) Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67, 89–104
    OpenUrlCrossRefPubMedWeb of Science
    1. Kieny M.,
    2. Chevallier A.
    (1979) Autonomy of tendon development in the embryonic chick wing. J. Embryol. Exp. Morphol 49, 153–165
    OpenUrlPubMedWeb of Science
    1. Logan C.,
    2. Khoo W. K.,
    3. Cado D.,
    4. Joyner A. L.
    (1993) Two enhancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts. Development 117, 905–916
    OpenUrlAbstract
    1. Morgan B. A.,
    2. Tabin C. J.
    (1993) The role of homeobox genes in limb development. Current Op. Genet. Dev 3, 668–674
    OpenUrlCrossRefPubMed
    1. Oliver G.,
    2. Sidell N.,
    3. Fiske W.,
    4. Heinzmann C.,
    5. Mohandas T.,
    6. Sparkes R. S.,
    7. De Robertis E. M.
    (1989) Complementary homeo protein gradients in developing limb buds. Genes Dev 3, 641–650
    OpenUrlAbstract/FREE Full Text
    1. Robson L. G.,
    2. Kara T.,
    3. Crawley A.,
    4. Tickle C.
    (1994) Tissue and cellular patterning of the musculature in chick wings. Development 120, 1265–1276
    OpenUrlAbstract
    1. Sassoon D.,
    2. Garner I.,
    3. Buckingham M. E.
    (1988) Transcripts for a-cardiac and a-skeletal actins are early markers for myogenesis in the mouse embryo. Development 104, 155–164
    OpenUrlAbstract
    1. Sullivan G. E.
    (1962) Anatomy and embryology of the wing musculature of the domestic fowl (Gallus). Aust. J. Zool 10, 458–516
    OpenUrlCrossRef
    1. Webb G. C.,
    2. Jenkins N. A.,
    3. Largaespada D. A.,
    4. Copeland N. G.,
    5. Fernandez C. S.,
    6. Bowtell D. D. L.
    (1993) Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. Genomics 18, 14–19
    OpenUrlCrossRefPubMedWeb of Science
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JOURNAL ARTICLES
Homeobox genes and connective tissue patterning
G. Oliver, R. Wehr, N.A. Jenkins, N.G. Copeland, B.N. Cheyette, V. Hartenstein, S.L. Zipursky, P. Gruss
Development 1995 121: 693-705;
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JOURNAL ARTICLES
Homeobox genes and connective tissue patterning
G. Oliver, R. Wehr, N.A. Jenkins, N.G. Copeland, B.N. Cheyette, V. Hartenstein, S.L. Zipursky, P. Gruss
Development 1995 121: 693-705;

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