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JOURNAL ARTICLES
Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
J.F. de Celis, A. Garcia-Bellido, S.J. Bray
Development 1996 122: 359-369;

Summary

The cells along the dorsoventral boundary of the Drosophila wing imaginal disc have distinctive properties and their specification requires Notch activity. Later in development, these cells will form the wing margin, where sensory organs and specialised trichomes appear in a characteristic pattern. We find that Notch is locally activated in these cells, as demonstrated by the restricted expression of the Enhancer of split proteins in dorsal and ventral cells abutting the D/V boundary throughout the third larval instar. Furthermore other genes identified by their involvement in Notch signaling during neurogenesis, such as Delta and Suppressor of Hairless, also participate in Notch function at the dorsoventral boundary. In addition, Serrate, a similar transmembrane protein to Delta, behaves as a ligand required in dorsal cells to activate Notch at the boundary. Notch gain-of-function alleles in which Notch activity is not restricted to the dorsoventral boundary cause miss-expression of cut and wingless and overgrowth of the disc, illustrating the importance of localised Notch activation for wing development.

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JOURNAL ARTICLES
Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
J.F. de Celis, A. Garcia-Bellido, S.J. Bray
Development 1996 122: 359-369;
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