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JOURNAL ARTICLES
hedgehog, wingless and orthodenticle specify adult head development in Drosophila
J. Royet, R. Finkelstein
Development 1996 122: 1849-1858;
J. Royet
University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia, 19104, USA.
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R. Finkelstein
University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia, 19104, USA.
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Summary

The adult head capsule of Drosophila forms primarily from the eye-antennal imaginal discs. Here, we demonstrate that the head primordium is patterned differently from the discs which give rise to the appendages. We show that the segment polarity genes hedgehog and wingless specify the identities of specific regions of the head capsule. During eye-antennal disc development, hedgehog and wingless expression initially overlap, but subsequently segregate. This regional segregation is critical to head specification and is regulated by the orthodenticle homeobox gene. We also show that orthodenticle is a candidate hedgehog target gene during early eye-antennal disc development.

Reference

    1. Ang S. L.,
    2. Rossant J.
    (1994) HNF-3 is essential for node and notochord formation in mouse development. Cell 78, 561–574
    OpenUrlCrossRefPubMedWeb of Science
    1. Baker N. E.
    (1988) Embryonic and imaginal requirements for wingless, a segment polarity gene in Drosophila. Dev. Biol 125, 96–108
    OpenUrlCrossRefPubMedWeb of Science
    1. Bally-Cuif L.,
    2. Cholley B.,
    3. Wassef M.
    (1995) Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech. Dev 53, 23–34
    OpenUrlCrossRefPubMedWeb of Science
    1. Bally-Cuif L.,
    2. Wassef M.
    (1995) Determination events in the nervous system of the vertebrate embryo. Curr. Op. Gen. Dev 5, 450–458
    OpenUrlCrossRefPubMedWeb of Science
    1. Basler K.,
    2. Struhl G.
    (1994) Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208–214
    OpenUrlCrossRefPubMedWeb of Science
    1. Bedichek S.
    (1934) New mutants. Dros. Inf. Serv 2, 9–.
    OpenUrl
    1. Bejsovec A.,
    2. Martinez Arias A.
    (1991) Roles of wingless in patterning the larval epidermis of Drosophila. Development 113, 471–485
    OpenUrlAbstract/FREE Full Text
    1. Blair S. S.
    (1995) Compartments and appendage development in Drosophila. BioEssays 17, 299–309
    OpenUrlCrossRefPubMedWeb of Science
    1. Brand A.,
    2. Perrimon N.
    (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401–415
    OpenUrlAbstract
    1. Brower D. L.
    (1986) engrailed gene expression in Drosophila imaginal discs. EMBO J 5, 2649–2656
    OpenUrlPubMedWeb of Science
    1. Campbell G.,
    2. Tomlinson A.
    (1995) Initiation of the proximodistal axis in insect legs. Development 121, 619–628
    OpenUrlAbstract
    1. Campbell G.,
    2. Weaver T.,
    3. Tomlinson A.
    (1993) Axis specification in the developing Drosophila appendage; the role of wingless, decapentaplegic, and the homeobox gene aristaless. Cell 74, 1113–1123
    OpenUrlCrossRefPubMedWeb of Science
    1. Capdevila J.,
    2. Estrada M. P.,
    3. Sanchez-Herrero E.,
    4. Guerrero I.
    (1994) The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBOJ 13, 71–82
    OpenUrlPubMedWeb of Science
    1. Cohen S. M.,
    2. Jurgens G.
    (1990) Gap-like segmentation genes that mediate Drosophila head development. Nature 346, 482–485
    OpenUrlCrossRefPubMedWeb of Science
    1. Cohen S. M.,
    2. Jurgens G.
    (1991) Drosophila headlines. Trends Genet 7, 267–272
    OpenUrlPubMedWeb of Science
    1. Couso J. P.,
    2. Bate M.,
    3. Martinez Arias A.
    (1993) A wingless -dependent polar coordinate system in Drosophila imaginal discs. Science 259, 484–489
    OpenUrlAbstract/FREE Full Text
    1. Diaz-Benjumea F. J.,
    2. Cohen B.,
    3. Cohen S.
    (1994) Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs. Nature 372, 175–179
    OpenUrlCrossRefPubMed
    1. DiNardo S.,
    2. Kuner J. M.,
    3. Theis J.,
    4. O'Farrell P. H.
    (1985) Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell 43, 59–69
    OpenUrlCrossRefPubMedWeb of Science
    1. Echelard Y.,
    2. Epstein D. J.,
    3. St-Jacques B.,
    4. Shen L.,
    5. Mohler J.,
    6. McMahon J. A.,
    7. McMahon A. P.
    (1993) Sonic Hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417–1430
    OpenUrlCrossRefPubMedWeb of Science
    1. Felsenfeld A. L.,
    2. Kennison J. A.
    (1995) Positional signaling by hedgehog in Drosophila imaginal disc development. Development 121, 1–10
    OpenUrlAbstract
    1. Finkelstein R.,
    2. Perrimon N.
    (1990) The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature 346, 485–488
    OpenUrlCrossRefPubMedWeb of Science
    1. Finkelstein R.,
    2. Perrimon N.
    (1991) The molecular genetics of head development in Drosophila melanogaster. Development 112, 899–912
    OpenUrlPubMedWeb of Science
    1. Gonzalez F.,
    2. Swales L.,
    3. Bejsovec A.,
    4. Skaer H.,
    5. Martinez Arias A.
    (1991) Secretion and movement of the wingless protein in the Drosophila embryo. Mech. Dev 35, 43–54
    OpenUrlCrossRefPubMedWeb of Science
    1. Hama C.,
    2. Ali Z.,
    3. Kornberg T. B.
    (1990) Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter. Genes Dev 4, 1079–1089
    OpenUrlAbstract/FREE Full Text
    1. Haynie J. L.,
    2. Bryant P. J.
    (1986) Development of the eye-antenna imaginal disc and morphogenesis of the adult head in Drosophila melanogaster. J. Exp. Zool 237, 293–308
    OpenUrlCrossRefPubMedWeb of Science
    1. Huang F.,
    2. Dambly-Chaudiere C.,
    3. Ghysen A.
    (1991) The emergence of sense organs in the wing disc of Drosophila. Development 111, 1087–1096
    OpenUrlAbstract/FREE Full Text
    1. Ingham P. W.
    (1988) The molecular genetics of embryonic pattern formation in Drosophila. Nature 335, 25–34
    OpenUrlCrossRefPubMedWeb of Science
    1. Ingham P. W.,
    2. Hidalgo A.
    (1993) Regulation of wingless transcription in the Drosophila embryo. Development 117, 283–291
    OpenUrlAbstract/FREE Full Text
    1. Ingham P. W.,
    2. Martinez Arias A.,
    3. Lawrence P. A.,
    4. Howard K.
    (1985) Expression of engrailed in the parasegment of Drosophila. Nature 317, 634–636
    OpenUrlCrossRef
    1. Kassis J.,
    2. Noll E.,
    3. VanSickle E. P.,
    4. Odenwald W. F.,
    5. Perrimon N.
    (1992) Altering the insertional specificity of a Drosophila transposable element. Proc. Natl. Acad. Sci. USA 89, 1919–1923
    OpenUrlAbstract/FREE Full Text
    1. Kornberg T.,
    2. Siden I.,
    3. O'Farrell P.,
    4. Simon M.
    (1985) The engrailed locus of Drosophila: In situ localization of transcripts reveals compartment-specific expression. Cell 40, 43–53
    OpenUrl
    1. Lee J. J.,
    2. Von Kessler D. P.,
    3. Parks S.,
    4. Beachy P. A.
    (1992) Secretion and localized transcription suggest a role in positional signalling for production of the segmentation gene hedgehog. Cell 70, 777–789
    OpenUrlCrossRefPubMedWeb of Science
    1. Ma C.,
    2. Moses K.
    (1995) wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye. Development 121, 2279–2289
    OpenUrlAbstract
    1. Ma C.,
    2. Zhou Y.,
    3. Beachy P. A.,
    4. Moses K.
    (1993) The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927–938
    OpenUrlCrossRefPubMedWeb of Science
    1. Mohler D.
    (1984) New mutants. Dros. Inf. Serv 60, 236–.
    OpenUrl
    1. Mohler J.
    (1995) Spatial regulation of segment polarity gene expression in the anterior terminal region of the Drosophila blastoderm embryo. Mech. Dev 50, 151–161
    OpenUrlCrossRefPubMed
    1. Mohler J.,
    2. Vani K.
    (1992) Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication and segmental patterning of Drosophila. Development 115, 957–971
    OpenUrlAbstract
    1. Morata G.,
    2. Lawrence P. A.
    (1975) Control of compartment development by the engrailed gene in Drosophila. Nature 255, 614–617
    OpenUrlCrossRefPubMed
    1. Morata G.,
    2. Lawrence P. A.
    (1978) Anterior and posterior compartments in the head of Drosophila. Nature 274, 473–474
    OpenUrlCrossRefPubMed
    1. Morata G.,
    2. Lawrence P. A.
    (1979) Development of the eye-antenna imaginal disc of Drosophila. Dev. Biol 70, 355–371
    OpenUrlCrossRefPubMed
    1. Mozer B. A.,
    2. Benzer S.
    (1993) Ingrowth by photoreceptor axons induces transcription of a retrotransposon in the developing Drosophila brain. Development 120, 1049–1058
    OpenUrlAbstract
    1. Patel N. H.,
    2. Martin-Blanco E.,
    3. Coleman K. G.,
    4. Poole S. F.,
    5. Ellis M. C.,
    6. Kornberg T. B.,
    7. Goodman C. S.
    (1989) Expression of engrailed proteins in arthropods, annelids, and chordates. Cell 58, 955–968
    OpenUrlCrossRefPubMedWeb of Science
    1. Perrimon N.
    (1995) Hedgehog and beyond. Cell 80, 517–520
    OpenUrlCrossRefPubMedWeb of Science
    1. Perrimon N.,
    2. Mahowald A. P.
    (1987) Multiple functions of segment polarity genes in Drosophila. Dev. Biol 119, 587–600
    OpenUrlCrossRefPubMedWeb of Science
    1. Royet J.,
    2. Finkelstein R.
    (1995) Pattern formation in Drosophila head development: the role of the orthodenticle homeobox gene. Development 121, 3561–3572
    OpenUrlAbstract
    1. Rubenstein J. L. R.,
    2. Martinez S.,
    3. Shimamura K.,
    4. Puelles L.
    (1994) The embryonic vertebrate forebrain: the prosomeric model. Science 266, 578–580
    OpenUrlFREE Full Text
    1. Schneider I.
    (1964) Differentiation of larval Drosophila eye-antennal discs in vitro. J. Exp. Zool 156, 91–104
    OpenUrlCrossRefPubMedWeb of Science
    1. Struhl G.,
    2. Basler K.
    (1993) Organizing activity of wingless protein in Drosophila. Cell 72, 527–540
    OpenUrlCrossRefPubMedWeb of Science
    1. Tabata T.,
    2. Eaton S.,
    3. Kornberg T. B.
    (1992) The Drosophilahedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev 6, 2635–2645
    OpenUrlAbstract/FREE Full Text
    1. Tabata T.,
    2. Kornberg T. B.
    (1994) Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89–102
    OpenUrlCrossRefPubMedWeb of Science
    1. Tashiro S.,
    2. Michiue T.,
    3. Higashijima S.,
    4. Zenno S.,
    5. Ishimaru S.,
    6. Takahashi F.,
    7. Orihara M.,
    8. Kojima T.,
    9. Saigo K.
    (1993) Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication. Gene 124, 183–189
    OpenUrlCrossRefPubMedWeb of Science
    1. van den Heuvel M.,
    2. Nusse R.,
    3. Johnston P.,
    4. Lawrence P.
    (1989) Distribution of the wingless gene product in Drosophila embryos: A protein involved in cell-cell communication. Cell 59, 739–749
    OpenUrlCrossRefPubMedWeb of Science
    1. Wieschaus E.,
    2. Perrimon N.,
    3. Finkelstein R.
    (1992) orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila. Development 115, 801–811
    OpenUrlAbstract/FREE Full Text
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JOURNAL ARTICLES
hedgehog, wingless and orthodenticle specify adult head development in Drosophila
J. Royet, R. Finkelstein
Development 1996 122: 1849-1858;
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JOURNAL ARTICLES
hedgehog, wingless and orthodenticle specify adult head development in Drosophila
J. Royet, R. Finkelstein
Development 1996 122: 1849-1858;

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