Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in
  • Log out

Search

  • Advanced search
Development
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Development

  • Log in
Advanced search

RSS  Twitter  Facebook  YouTube 

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
JOURNAL ARTICLES
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
V. Wiersdorff, T. Lecuit, S. M. Cohen, M. Mlodzik
Development 1996 122: 2153-2162;
V. Wiersdorff
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Lecuit
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. M. Cohen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Mlodzik
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & metrics
  • PDF
Loading

Summary

Decapentaplegic (Dpp), a member of the TGF-betta family of cytokines, has been implicated in many patterning processes in Drosophila, including the initial steps of pattern formation in the developing eye. We show that the Mothers against dpp (Mad) gene is required for dpp signaling during eye development. Clonal analysis demonstrates a cell-autonomous function for Mad and genetic interactions indicate that Mad is an essential component of the signal transduction pathway downstream of the Dpp receptors in responding cells. Mad-mediated dpp signaling is absolutely required for the initiation of the morphogenetic furrow in the eye, but has only a minor role in its subsequent propagation across the eye

Reference

    1. Arora K.,
    2. Dai H.,
    3. Kazuko S. G.,
    4. Jamal J.,
    5. O'Connor M. B.,
    6. Letsou A.,
    7. Warrior R.
    (1995) The Drosophila schnurri gene acts in the Dpp/TGF-signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell 81, 781–790
    OpenUrlCrossRefPubMedWeb of Science
    1. Attisano L.,
    2. Wrana J. L.,
    3. Lopez-Casillas F.,
    4. Massague J.
    (1994) TGF-receptors and actions. Biochim. Biophys. Acta 1222, 71–80
    OpenUrlPubMed
    1. Blackman R. K.,
    2. Sanicola M.,
    3. Raftery L. A.,
    4. Gillevet T.,
    5. Gelbart W. M.
    (1991) An extensive 3 cis -regulatory region directs the imaginal disc expression of decapentaplegic, a member of the TGF-family in Drosophila. Development 111, 657–666
    OpenUrlAbstract
    1. Capdevila J.,
    2. Guerrero I.
    (1994) Targeted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J 13, 4459–4468
    OpenUrlPubMedWeb of Science
    1. Chanut F.,
    2. Heberlein U.
    (1995) Role of the morphogenetic furrow in establishing polarity in the Drosophila eye. Development 121, 4085–4094
    OpenUrlAbstract
    1. Diaz-Benjumea F. J.,
    2. Cohen B.,
    3. Cohen S. M.
    (1994) Cell interaction between compartments establishes the proximal-distal axis of Drosophila limbs. Nature 372, 175–179
    OpenUrlCrossRefPubMed
    1. Ellis M. C.,
    2. Weber U.,
    3. Wiersdorff V.,
    4. Mlodzik M.
    (1994) Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye. Development 120, 1959–1969
    OpenUrlAbstract
    1. Ferguson E. L.,
    2. Anderson K. V.
    (1992) decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71, 451–461
    OpenUrlCrossRefPubMedWeb of Science
    1. Grieder N. C.,
    2. Nellen D.,
    3. Burke R.,
    4. Basler K.,
    5. Affolter M.
    (1995) schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell 81, 791–800
    OpenUrlCrossRefPubMedWeb of Science
    1. Hahn S. A.,
    2. Schutte M.,
    3. Shamsul Hoque A. T. M.,
    4. Moskaluk C. A.,
    5. da Costa L. T.,
    6. Rozenblum E.,
    7. Weinstein C. L.,
    8. Fischer A.,
    9. Yeo C. J.,
    10. Hruban R. H.,
    11. Kern S. E.
    (1996). DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350–353
    OpenUrlAbstract
    1. Hay B.,
    2. Wolff T.,
    3. Rubin G. M.
    (1994) Expression of baculovirus P35 prevents cell death in Drosophila. Development 120, 2121–2129
    OpenUrlAbstract
    1. Heberlein U.,
    2. Moses K.
    (1995) Mechanisms of Drosophila retinal morphogenesis: the virtues of being progressive. Cell 81, 987–990
    OpenUrlCrossRefPubMedWeb of Science
    1. Heberlein U.,
    2. Singh C. M.,
    3. Luk A. Y.,
    4. Donohue T. J.
    (1995) Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 373, 709–711
    OpenUrlCrossRefPubMedWeb of Science
    1. Heberlein U.,
    2. Wolff T.,
    3. Rubin G. M.
    (1993) The TGFhomolog dpp and the segment polarity gene hedgehog are required for the propagation of a morphogenetic wave in the Drosophila retina. Cell 75, 913–926
    OpenUrlCrossRefPubMedWeb of Science
    1. Jiang J.,
    2. Struhl G.
    (1995) Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563–572
    OpenUrlCrossRefPubMedWeb of Science
    1. Lepage T.,
    2. Cohen S. M.,
    3. Diaz-Benjumea F. J.,
    4. Parkhurst S. M.
    (1995) Signal transduction by cAMP-dependent protein kinase A in Drosophila limb pattern. Nature 373, 711–715
    OpenUrlCrossRefPubMedWeb of Science
    1. Letsou A.,
    2. Arora K.,
    3. Wrana J. L.,
    4. Simin K.,
    5. Twombly V.,
    6. Jamal J.,
    7. Staeheling-Hampton K.,
    8. Hofmann F. M.,
    9. Gelbart W. M.,
    10. Massague J.,
    11. O'Connor M. B.
    (1995) Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF-receptor family. Cell 80, 899–908
    OpenUrlCrossRefPubMedWeb of Science
    1. Li W.,
    2. Ohlmeyer J. T.,
    3. Lane M. E.,
    4. Kalderon D.
    (1995) Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553–562
    OpenUrlCrossRefPubMedWeb of Science
    1. Ma C.,
    2. Moses K.
    (1995) wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye. Development 121, 2279–2289
    OpenUrlAbstract
    1. Ma C.,
    2. Zhou Y.,
    3. Beachy P. A.,
    4. Moses K.
    (1993) The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927–938
    OpenUrlCrossRefPubMedWeb of Science
    1. Mardon G.,
    2. Solomon N. M.,
    3. Rubin G. M.
    (1994) dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development 120, 3473–3486
    OpenUrlAbstract
    1. Massague J.
    (1992) Receptors for the TGF-family. Cell 69, 1067–1070
    OpenUrlCrossRefPubMedWeb of Science
    1. Masucci J. D.,
    2. Miltenberger R. J.,
    3. Hoffmann F. M.
    (1990) Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal discs is regulated by 3 cis -regulatory elements. Genes Dev 4, 2011–2023
    OpenUrlAbstract/FREE Full Text
    1. Mlodzik M.,
    2. Hiromi Y.,
    3. Weber U.,
    4. Goodman C. S.,
    5. Rubin G. M.
    (1990) The Drosophilaseven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell 60, 211–224
    OpenUrlCrossRefPubMedWeb of Science
    1. Nellen D.,
    2. Affolter M.,
    3. Basler K.
    (1994) Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78, 225–237
    OpenUrlCrossRefPubMedWeb of Science
    1. Newfeld S. J.,
    2. Chartoff E. H.,
    3. Graff J. M.,
    4. Melton D. A.,
    5. Gelbart W. M.
    (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-responsive cells. Development 122, 2099–2108
    OpenUrlAbstract
    1. Padgett R. W.,
    2. Wozney J. M.,
    3. Gelbart W. M.
    (1993) Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 90, 2905–2909
    OpenUrlAbstract/FREE Full Text
    1. Pan D.,
    2. Rubin G. M.
    (1995) cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543–552
    OpenUrlCrossRefPubMedWeb of Science
    1. Raftery L. A.,
    2. Twombly V.,
    3. Wharton K.,
    4. Gelbart W. M.
    (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139, 241–254
    OpenUrlAbstract/FREE Full Text
    1. Ready D. F.
    (1989) A multifaceted approach to neural development. Trends Neurosci 12, 102–110
    OpenUrlCrossRefPubMedWeb of Science
    1. Ruberte E.,
    2. Marty T.,
    3. Nellen D.,
    4. Affolter M.,
    5. Basler K.
    (1995) An absolute requirement for both the type II and type I receptors, punt and thickveins, for Dpp signaling in vivo. Cell 80, 889–897
    OpenUrlCrossRefPubMedWeb of Science
    1. Sampath T. K.,
    2. Rashka K. E.,
    3. Doctor J. S.,
    4. Tucker R. F.,
    5. Hoffmann F. M.
    (1993) Drosophila TGF-superfamily proteins induce endochondrial bone formation in mammals. Proc. Natl. Acad. Sci. USA 90, 6004–6008
    OpenUrlAbstract/FREE Full Text
    1. Savage C.,
    2. Das P.,
    3. Finelli A. L.,
    4. Townsend S. R.,
    5. Sun C.-Y.,
    6. Baird S. E.,
    7. Padgett R. W.
    (1996) C. elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factorpathway components. Proc. Natl. Acad. Sci. USA 93, 790–794
    OpenUrlAbstract/FREE Full Text
    1. Sekelsky J. J.,
    2. Newfeld S. J.,
    3. Raftery L. A.,
    4. Chartoff E. H.,
    5. Gelbart W. M.
    (1995) Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophilamelanogaster. Genetics 139, 1347–1358
    OpenUrlAbstract/FREE Full Text
    1. Spradling A. C.,
    2. Rubin G. M.
    (1982) Transposition of cloned P-elements into Drosophila germ line chromosomes. Science 218, 341–347
    OpenUrlAbstract/FREE Full Text
    1. Strutt D. I.,
    2. Mlodzik M.
    (1995) Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. Development 121, 4247–4256
    OpenUrlAbstract
    1. Strutt D. I.,
    2. Wiersdorff V.,
    3. Mlodzik M.
    (1995) Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373, 705–709
    OpenUrlCrossRefPubMed
    1. Tomlinson A.
    (1988) Cellular interactions in the developing Drosophila eye. Development 104, 183–193
    OpenUrlPubMedWeb of Science
    1. Tomlinson A.,
    2. Ready D. F.
    (1987) Cell fate in the Drosophila Ommatidium. Dev. Biol 123, 264–275
    OpenUrlCrossRefPubMedWeb of Science
    1. Török T.,
    2. Tick G.,
    3. Alvarado M.,
    4. Kiss I.
    (1993) P-lacW insertional mutagenesis on the second chromosome of Drosophilamelanogaster: isolation of lethals with different overgrowth phenotypes. Genetics 135, 71–80
    OpenUrlAbstract/FREE Full Text
    1. Treisman J. E.,
    2. Lai Z.-C.,
    3. Rubin G. M.
    (1995) shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-responsive gene. Development 121, 2835–2845
    OpenUrlAbstract
    1. Treisman J. E.,
    2. Rubin G. M.
    (1995) wingless inhibits morphogenetic furrow movement in the Drosophila eye disc. Development 121, 3519–3527
    OpenUrlAbstract
    1. Vincent J.-P.,
    2. Girdham C. H.,
    3. O'Farrell P. H.
    (1994) A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev. Biol 164, 328–331
    OpenUrlCrossRefPubMedWeb of Science
    1. Wall N. A.,
    2. Hogan B. L. M.
    (1994) TGFrelated genes in development. Curr. Opin. Genet. Dev 4, 517–522
    OpenUrlCrossRefPubMed
    1. Wehrli M.,
    2. Tomlinson A.
    (1995) Epithelial planar polarity in the developing Drosophila eye. Development 121, 2451–2459
    OpenUrlAbstract
    1. Wharton K. A.,
    2. Ray R. P.,
    3. Gelbart W. M.
    (1993) An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo. Development 117, 807–822
    OpenUrlAbstract
    1. Wieser R.,
    2. Wrana J.,
    3. Massague J.
    (1995) GS domain mutants that constitutively activate TR-1, the downstream signaling component in the TGF-b receptor complex. EMBO J 14, 2199–2208
    OpenUrlPubMedWeb of Science
    1. Wrana J. L.,
    2. Attisano L.,
    3. Wieser R.,
    4. Ventura F.,
    5. Massague J.
    (1994) Mechanism of activation of the TGF-receptor. Nature 370, 341–347
    OpenUrlCrossRefPubMedWeb of Science
    1. Xu T.,
    2. Rubin G. M.
    (1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223–1237
    OpenUrlAbstract
    1. Zecca M.,
    2. Basler K.,
    3. Struhl G.
    (1995) Sequential organising activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265–2278
    OpenUrlAbstract
Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

 Download PDF

Email

Thank you for your interest in spreading the word on Development.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
(Your Name) has sent you a message from Development
(Your Name) thought you would like to see the Development web site.
Share
JOURNAL ARTICLES
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
V. Wiersdorff, T. Lecuit, S. M. Cohen, M. Mlodzik
Development 1996 122: 2153-2162;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
JOURNAL ARTICLES
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
V. Wiersdorff, T. Lecuit, S. M. Cohen, M. Mlodzik
Development 1996 122: 2153-2162;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
  • Info & metrics
  • PDF

Related articles

Cited by...

More in this TOC section

  • Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice
  • The dermomyotome dorsomedial lip drives growth and morphogenesis of both the primary myotome and dermomyotome epithelium
  • REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity
Show more JOURNAL ARTICLES

Similar articles

Other journals from The Company of Biologists

Journal of Cell Science

Journal of Experimental Biology

Disease Models & Mechanisms

Biology Open

Advertisement

The people behind the papers – George Britton and Aryeh Warmflash

George and Aryeh

First author George Britton and his supervisor Aryeh Warmflash discuss their new Development paper in which they apply advanced in vitro culturing techniques to investigate embryonic ectoderm patterning.


Travelling Fellowship – New imaging approach unveils a bigger picture

Highlights from Travelling Fellowship trips

Find out how Pamela Imperadore’s Travelling Fellowship grant from The Company of Biologists took her to Germany, where she used new imaging techniques to investigate the cellular machinery underlying octopus arm regeneration. Don’t miss the next application deadline for 2020 travel, coming up on 29 November. Where will your research take you?


Primer – Principles and applications of optogenetics in developmental biology

Schematic demonstrating the approaches to controlling protein activity using optogenetics.

Protein function can be controlled by light using optogenetic techniques. In their new Primer, Stefano De Renzis and his colleagues in Heidelberg provide an overview of the most commonly used optogenetic tools and their application in developmental biology.


preLights – Self-organised symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation

Sundar Naganathan

preLighter Sundar Naganathan explains his selected preprint by Vikas Trivedi, Benjamin Steventon and their co-workers on pescoids, a new in vitro model system to study early zebrafish embryogenesis.


Spotlight – Can laboratory model systems instruct human limb regeneration?

An extract from a schematic demonstrating the possible pipeline for how discovery in lab model systems can influence applications for regenerative therapies.

One of the most challenging objectives of tissue regeneration research is regrowth of a lost or amputated limb. Here, Ben Cox, Maximina Yun and Kenneth Poss outline the research avenues yet to be explored to move closer to this capstone achievement.


Articles of interest in our sister journals

Tox4 modulates cell fate reprogramming

Lotte Vanheer, Juan Song, Natalie De Geest, Adrian Janiszewski, Irene Talon, Caterina Provenzano, Taeho Oh, Joel Chappell, Vincent Pasque
Journal of Cell Science

Drosophila melanogaster: a simple system for understanding complexity

Stephanie E. Mohr, Norbert Perrimon
Disease Models & Mechanisms

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Sign up for alerts

About us

  • About Development
  • About the Node
  • Editors and board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact Development
  • Subscriptions
  • Advertising
  • Feedback

 Twitter   YouTube   LinkedIn

© 2019   The Company of Biologists Ltd   Registered Charity 277992