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JOURNAL ARTICLES
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
S.H. Johnston, C. Rauskolb, R. Wilson, B. Prabhakaran, K.D. Irvine, T.F. Vogt
Development 1997 124: 2245-2254;

Summary

The formation of boundaries between groups of cells is a universal feature of metazoan development. Drosophila fringe modulates the activation of the Notch signal transduction pathway at the dorsal-ventral boundary of the wing imaginal disc. Three mammalian fringe-related family members have been cloned and characterized: Manic, Radical and Lunatic Fringe. Expression studies in mouse embryos support a conserved role for mammalian Fringe family members in participation in the Notch signaling pathway leading to boundary determination during segmentation. In mammalian cells, Drosophila fringe and the mouse Fringe proteins are subject to posttranslational regulation at the levels of differential secretion and proteolytic processing. When misexpressed in the developing Drosophila wing imaginal disc the mouse Fringe genes exhibit conserved and differential effects on boundary determination.

REFERENCES

    1. Altschul S. F.,
    2. Gish W.,
    3. Miller W.,
    4. Meyers E. W.,
    5. Lipman D.
    (1990) Basic local alignment search tool. J. Mol Biol 215, 403–410
    OpenUrlCrossRefPubMedWeb of Science
    1. Amo F. F. d.,
    2. Smith D. E.,
    3. Swiatek P. J.,
    4. Gendron-Maguire M.,
    5. Greenspan R. J.,
    6. McMahon A. P.,
    7. Gridley T.
    (1992) Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development 115, 737–744
    OpenUrlAbstract/FREE Full Text
    1. Artavanis-Tsakonas S.,
    2. Matsuno K.,
    3. Fortini M. E.
    (1995) Notch signaling. Science 268, 225–232
    OpenUrlAbstract/FREE Full Text
    1. Barr P. J.
    (1991) Mammalian Subtilisins: The long-sought dibasic processing endoproteases. Cell 66, 1–3
    OpenUrlCrossRefPubMedWeb of Science
    1. Bettenhausen B.,
    2. Angelis M. H. d.,
    3. Simon D.,
    4. Guenet J.-L.,
    5. Gossler A.
    (1995) Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121, 2407–2418
    OpenUrlAbstract
    1. Bie I. D.,
    2. Savaria D.,
    3. Roebroeck A. J.,
    4. Day R.,
    5. Lazeure C.,
    6. Ven W. J. v. d.,
    7. Seidah N. G.
    (1995) Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1-CRR, dfurin1-X, and dfurin2. J. Biol. Chem 270, 1020–1028
    OpenUrlAbstract/FREE Full Text
    1. Blair S. S.
    (1993) Mechanism of compartment formation: evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila. Development 119, 339–351
    OpenUrlAbstract
    1. Boone C.,
    2. Bussey H.,
    3. Greene D.,
    4. Thomas D. Y.,
    5. Vernet T.
    (1986) Yeast killer toxin: site-directed mutations implicate the precursor protein as the immunity component. Cell 46, 105–113
    OpenUrlCrossRefPubMedWeb of Science
    1. Bradley R. S.,
    2. Brown A. M. C.
    (1990) The proto-oncogene int - 1 encodes a secreted protein associated with the extracellular matrix. EMBO J 9, 1569–1575
    OpenUrlPubMedWeb of Science
    1. Brand A.,
    2. Perrimon N.
    (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401–415
    OpenUrlAbstract
    1. Bussey H.
    (1991) K1 killer toxin, a pore-forming protein from yeast. Molecular Microbiology 5, 2339–2343
    OpenUrlCrossRefPubMedWeb of Science
    1. Candia A. F.,
    2. Hu H.,
    3. Crosby J.,
    4. Lalley P. A.,
    5. Noden D.,
    6. Nadeau J. H.,
    7. Wright C. V. E.
    (1992) Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development 116, 1123–1136
    OpenUrlAbstract/FREE Full Text
    1. Cheng H. J.,
    2. Nakamoto M.,
    3. Bergemann A. D.,
    4. Flanagan J. G.
    (1995) Complementary gradients in expression and binding of Elf-1 and Mek-4 in development of the topographic retinotectal projection map. Cell 82, 371–381
    OpenUrlCrossRefPubMedWeb of Science
    1. Chitnis A.,
    2. Henrique D.,
    3. Lewis J.,
    4. Ish-Horowicz D.,
    5. Kintner C.
    (1995) Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature 375, 761–766
    OpenUrlCrossRefPubMedWeb of Science
    1. Conlon R. A.,
    2. Reaume A. G.,
    3. Rossant J.
    (1995) Notch1 is required for the coordinate segmentation of somites. Development 121, 1533–1545
    OpenUrlAbstract
    1. de Celis J. F.,
    2. Garcia-Bellido A.,
    3. Bray S. J.
    (1996) Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 122, 359–369
    OpenUrlAbstract
    1. Diaz-Benjumea F. J.,
    2. Cohen S. M.
    (1995) Serrate signals through Notch to establish a Wingless -dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121, 4215–4225
    OpenUrlAbstract
    1. Doherty D.,
    2. Feger G.,
    3. Younger-Shepherd S.,
    4. Jan L. Y.,
    5. Jan Y. N.
    (1996) Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev 10, 421–434
    OpenUrlAbstract/FREE Full Text
    1. Ellisen L. W.,
    2. Bird J.,
    3. West D. C.,
    4. Soreng A. L.,
    5. Reynolds T. C.,
    6. Smith S. D.,
    7. Sklar J.
    (1991) TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649–661
    OpenUrlCrossRefPubMedWeb of Science
    1. Fahrner K.,
    2. Hogan B. L. M.,
    3. Flavell R. A.
    (1987) Transcription of the H-2 and Qa genes in embryonic and adult mice. EMBO J 6, 1265–1271
    OpenUrlPubMed
    1. Flanagan J. G.,
    2. Leder P.
    (1990) The Kit ligand: a cell surface molecule altered in Steel mutant fibroblasts. Cell 63, 185–194
    OpenUrlCrossRefPubMedWeb of Science
    1. Garcia-Bellido A.
    (1975) Genetic control of wing disc development in Drosophila. Ciba Foundation Symposium 29, 161–182
    1. Hinz U.,
    2. Giebel B.,
    3. Campos-Ortega J.
    (1994) The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 79, 77–87
    1. Irvine K. D.,
    2. Wieschaus E.
    (1994) fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79, 595–606
    OpenUrlCrossRefPubMedWeb of Science
    1. Jessell T. M.,
    2. Melton D. A.
    (1992) Diffusible factors in vertebrate embryonic induction. Cell 68, 257–270
    OpenUrlCrossRefPubMedWeb of Science
    1. Keynes R. J.,
    2. Stern C. D.
    (1988) Mechanisms of vertebrate segmentation. Development 103, 413–430
    OpenUrlPubMedWeb of Science
    1. Kim J.,
    2. Irvine K. D.,
    3. Carroll S. B.
    (1995) Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell 82, 795–802
    OpenUrlCrossRefPubMedWeb of Science
    1. Kim J.,
    2. Sebring A.,
    3. Esch J. J.,
    4. Kraus M. E.,
    5. Vorwerk K.,
    6. Magee J.,
    7. Carroll S. B.
    (1996) Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133–138
    OpenUrlCrossRefPubMed
    1. Lawrence P. A.,
    2. Struhl G.
    (1996) Morphogens, compartments, and pattern: Lessons from Drosophila. Cell 85, 951–961
    OpenUrlCrossRefPubMedWeb of Science
    1. Lee J. J.,
    2. Ekker S. C.,
    3. Kessler D. P. v.,
    4. Porter J. A.,
    5. Sun B. I.,
    6. Beachy P. A.
    (1994) Autoproteolysis in hedgehog protein biogenesis. Science 266, 1528–1537
    OpenUrlAbstract/FREE Full Text
    1. Lewis J.
    (1996) Neurogenic genes and vertebrate neurogenesis. Curr. Opin. Neurobiol 6, 3–10
    OpenUrlCrossRefPubMedWeb of Science
    1. Lindsell C. E.,
    2. Shawber C. J.,
    3. Boulter J.,
    4. Weinmaster G.
    (1995) Jagged: a mammalian ligand that activates Notch1. Cell 80, 909–917
    OpenUrlCrossRefPubMedWeb of Science
    1. Lumsden A.,
    2. Krumlauf R.
    (1996) Patterning the vertebrate neuraxis. Science 274, 1109–1115
    OpenUrlAbstract/FREE Full Text
    1. Morisato D.,
    2. Anderson K.V.
    (1995) Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Ann. Rev. Genet 29, 371–399
    OpenUrlCrossRefPubMedWeb of Science
    1. Nieto M. A.,
    2. Gilardi-Hebenstreit P.,
    3. Charnay P.,
    4. Wilkinson D. G.
    (1992) A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 116, 1137–1150
    OpenUrlAbstract/FREE Full Text
    1. Riddle R. D.,
    2. Johnson R. L.,
    3. Laufer E.,
    4. Tabin C.
    (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401–1416
    OpenUrlCrossRefPubMedWeb of Science
    1. Roebroek A. J.,
    2. Ayoubi T. A.,
    3. Creemers J. W.,
    4. Pauli I. G.,
    5. Ven W. v. d.
    (1995) The Dfur2 gene of Drosophilamelanogaster: Genetic organization, expression during embryogenesis, and pro-protein processing activity of its translational product Dfurin2. DNA and Cell Biology 14, 223–234
    OpenUrlCrossRefPubMed
    1. Rubin G. M.,
    2. Spradling A. C.
    (1982) Genetic transformation of Drosophila with transposable element vectors. Science 218, 348–353
    OpenUrlAbstract/FREE Full Text
    1. Rulifson E.J.,
    2. Blair S.S.
    (1995) Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing neurogenesis in Drosophila. Development 121, 2813–2824
    OpenUrlAbstract
    1. Speicher S.A.,
    2. Thomas U.,
    3. Hinz U.,
    4. Knust E.
    (1994) The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development 120, 535–544
    OpenUrlAbstract
    1. Tam P. P. L.,
    2. Trainor P. A.
    (1994) Specification and segmentation of the paraxial mesoderm. Anat. Embryol 189, 275–305
    OpenUrlPubMed
    1. Tanabe Y.,
    2. Jessell T. M.
    (1996) Diversity and pattern in the developing spinal cord. Science 274, 1115–1123
    OpenUrlAbstract/FREE Full Text
    1. Thomsen G. H.,
    2. Melton D. A.
    (1993) Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell 74, 433–441
    OpenUrlCrossRefPubMedWeb of Science
    1. van den Heuvel M.,
    2. Nusse R.,
    3. Johnston P.,
    4. Lawrence P.A.
    (1989) Distribution of the wingless gene product in Drosophila embryos: A protein involved in cell-cell communication. Cell 59, 739–749
    OpenUrlCrossRefPubMedWeb of Science
    1. Wu J. Y.,
    2. Wen L.,
    3. Zhang W.-J.,
    4. Rao Y.
    (1996) The secreted product of Xenopus gene lunatic Fringe, a vertebrate signaling molecule. Science 273, 355–358
    OpenUrlAbstract
    1. Zecca M.,
    2. Basler K.,
    3. Struhl G.
    (1996) Direct and long-range action of a wingless morphogen gradient. Cell 87, 833–844
    OpenUrlCrossRefPubMedWeb of Science
    1. Zettlmeissl G.,
    2. Gregersen J.-P.,
    3. Duport J. M.,
    4. Mehdi S.,
    5. Reiner G.,
    6. Seed B.
    (1990) Expression and characterization of human CD4: Immunoglobulin fusion proteins. DNA and Cell Biology 9, 347–353
    OpenUrlCrossRefPubMedWeb of Science
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JOURNAL ARTICLES
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
S.H. Johnston, C. Rauskolb, R. Wilson, B. Prabhakaran, K.D. Irvine, T.F. Vogt
Development 1997 124: 2245-2254;
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