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JOURNAL ARTICLES
A role for Siamois in Spemann organizer formation
M.J. Fan, S.Y. Sokol
Development 1997 124: 2581-2589;
M.J. Fan
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S.Y. Sokol
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Summary

The vertebrate body plan is specified in the early embryo through the inductive influence of the organizer, a special region that forms on the dorsalmost side of the embryo at the beginning of gastrulation. In Xenopus, the homeobox gene Siamois is activated prior to gastrulation in the area of organizer activity and is capable of inducing a secondary body axis when ectopically expressed. To elucidate the function of endogeneous Siamois in dorsoventral axis formation, we made a dominant repressor construct (SE) in which the Siamois homeodomain was fused to an active repression domain of Drosophila engrailed. Overexpression of 1–5 pg of this chimeric mRNA in the early embryo blocks axis development and inhibits activation of dorsal, but not ventrolateral, marginal zone markers. At similar expression levels, SE proteins with altered DNA-binding specificity do not have the same effect. Coexpression of mRNA encoding wild-type Siamois, but not a mutated Siamois, restores dorsal development to SE embryos. Furthermore, SE strongly blocks axis formation triggered by beta-catenin but not by the organizer product noggin. These results suggest that Siamois function is essential for beta-catenin-mediated formation of the Spemann organizer, and that Siamois acts prior to noggin in specifying dorsal development.

REFERENCES

    1. Acampora D.,
    2. Mazan S.,
    3. Lallemand Y.,
    4. Avantaggiato V.,
    5. Maury M.,
    6. Simeone A.,
    7. Brulet P.
    (1995) Forebrain and midbrain regions aredeleted in Otx2−/−mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279–3290
    OpenUrlAbstract
    1. Ang S.-L.,
    2. Rossant J.
    (1994) HNF-3 is essential for node and notochord formation in mouse development. Cell 78, 561–574
    OpenUrlCrossRefPubMedWeb of Science
    1. Ang S.-L.,
    2. Jin O.,
    3. Rhinn M.,
    4. Daigle N.,
    5. Stevenson L.,
    6. Rossant J.
    (1996) A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development 122, 243–252
    OpenUrlAbstract
    1. Badiani P.,
    2. Corbella P.,
    3. Kioussis D.,
    4. Marvel J.,
    5. Weston K.
    (1994) Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev 8, 770–782
    OpenUrlAbstract/FREE Full Text
    1. Behrens J.,
    2. von Kries J. P.,
    3. Kuhl M.,
    4. Bruhn L.,
    5. Wedlich D.,
    6. Grosschedl R.,
    7. Birchmeier W.
    (1996) Functional interaction of-catenin with the transcription factor LEF-1. Nature 382, 638–642
    OpenUrlCrossRefPubMed
    1. Blumberg B.,
    2. Wright C. V. E.,
    3. De Robertis E. M.,
    4. Cho K. W. Y.
    (1991) Organizer-specific homeobox genes in Xenopuslaevis embryos. Science 253, 194–196
    OpenUrlAbstract/FREE Full Text
    1. Bouwmeester T.,
    2. Kim S.-H.,
    3. Sasai Y.,
    4. Lu B.,
    5. De Robertis E. M.
    (1996) Cerberus is a head-inducing secreted factor expressed in the anterior ectoderm of Spemann's organizer. Nature 382, 595–601
    OpenUrlCrossRefPubMed
    1. Brannon M.,
    2. Kimelman D.
    (1996) Activation of Siamois by the Wnt pathway. Dev. Biol 180, 344–347
    OpenUrlCrossRefPubMedWeb of Science
    1. Carnac G.,
    2. Kodjabachian L.,
    3. Gurdon J. B.,
    4. Lemaire P.
    (1996) The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm. Development 122, 3055–3065
    OpenUrlAbstract
    1. Christian J. L.,
    2. McMahon J. A.,
    3. McMahon A. P.,
    4. Moon R. T.
    (1991) Xwnt 8, a XenopusWnt −1/ int −1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development 111, 1045–1055
    OpenUrlAbstract/FREE Full Text
    1. Conlon F. L.,
    2. Sedgwick S. G.,
    3. Weston K. M.,
    4. Smith J. C.
    (1996) Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm. Development 122, 2427–2435
    OpenUrlAbstract
    1. Dominguez I.,
    2. Itoh K.,
    3. Sokol S. Y.
    (1995) Role of glycogen synthase kinase 3β as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc. Natl. Acad. Sci. USA 92, 8498–8502
    OpenUrlAbstract/FREE Full Text
    1. Fagotto F.,
    2. Guger K.,
    3. Gumbiner B. M.
    (1997) Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/-catenin signaling pathway, but not by Vg1, Activin or Noggin. Development 124, 453–460
    OpenUrlAbstract
    1. Gerhart J.,
    2. Danilchik M.,
    3. Doniach T.,
    4. Roberts S.,
    5. Rowning B.,
    6. Stewart R.
    (1989) Cortical rotation of the Xenopus egg: consequences for the anterioposterior pattern of embryonic dorsal development. Development 107, 31–51
    1. Guger K.,
    2. Gumbiner B. M.
    (1995) -catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning. Dev. Biol 172, 115–125
    OpenUrlCrossRefPubMedWeb of Science
    1. Han K.,
    2. Manley J. L.
    (1993) Functional domains of the Drosophila Engrailed protein. EMBO J 12, 2723–2733
    OpenUrlPubMedWeb of Science
    1. Hanna-Rose W.,
    2. Hansen U.
    (1996) Active repression mechanisms of eukaryotic transcription repressors. Trends Genet 12, 229–234
    OpenUrlCrossRefPubMedWeb of Science
    1. Hanes S. D.,
    2. Brent R.
    (1989) DNA specificity of the Bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell 57, 1274–1283
    OpenUrl
    1. He X.,
    2. Saint-Jeannet J.-P.,
    3. Woodgett J. R.,
    4. Varmus H. E.,
    5. Dawid I. B.
    (1995) Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374, 617–622
    OpenUrlCrossRefPubMed
    1. Heasman J.,
    2. Crawford A.,
    3. Goldstone K.,
    4. Garner-Hamrick P.,
    5. Gumbiner B.,
    6. McCrea P.,
    7. Kintner C.,
    8. Noro C. Y.,
    9. Wylie C.
    (1994) Overepxression of cadherins and underexpression of-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 79, 791–803
    OpenUrlCrossRefPubMedWeb of Science
    1. Hemmati-Brivanlou A.,
    2. Harland R. M.
    (1989) Expression of an engrailed- related protein is induced in the anterior neural ectoderm of early Xenopus embryos. Development 106, 611–617
    OpenUrlAbstract
    1. Horton R.,
    2. Cai Z.,
    3. Ho S.,
    4. Pease L.
    (1990) Gene splicing by overlap extension: tailor made genes using the polymerase chain reaction. BioTechniques 8, 528–535
    OpenUrlPubMedWeb of Science
    1. Huber O.,
    2. Korn R.,
    3. McLaughlin J.,
    4. Ohsugi M.,
    5. Herrmann B. G.,
    6. Kemler R.
    (1996) Nuclear localization of-catenin by interaction with transcription factor LEF-1. Mech. Dev 59, 3–10
    OpenUrlCrossRefPubMedWeb of Science
    1. Itoh K.,
    2. Tang T. L.,
    3. Neel B. G.,
    4. Sokol S. Y.
    (1995) Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase. Development 121, 3979–3988
    OpenUrlAbstract
    1. Jaynes J. B.,
    2. O'Farrell P. H.
    (1991) Active repression of transcription by the Engrailed homeodomain protein. EMBO J 10, 1427–1433
    OpenUrlPubMedWeb of Science
    1. John A.,
    2. Smith S. T.,
    3. Jaynes J. B.
    (1995) Inserting the Ftz homeodomain into Engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo. Development 121, 1801–1813
    OpenUrlAbstract
    1. Kao K. R.,
    2. Elinson R. P.
    (1988) The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos. Dev. Biol 127, 64–77
    OpenUrlCrossRefPubMedWeb of Science
    1. Karnovsky A.,
    2. Klymkowsky M. W.
    (1995) Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin. Proc. Natl. Acad. Sci. USA 92, 4522–4526
    OpenUrlAbstract/FREE Full Text
    1. Krieg P. A.,
    2. Melton D. A.
    (1985) Developmental regulation of a gastrula specific gene injected into fertilized Xenopus eggs. EMBO J 4, 3463–3471
    OpenUrlPubMedWeb of Science
    1. Lamb T. M.,
    2. Knecht A. K.,
    3. Smith W. C.,
    4. Stachel S. E.,
    5. Economides A. N.,
    6. Stahl N.,
    7. Yancopolous G. D.,
    8. Harland R. M.
    (1993) Neural induction by the secreted polypeptide noggin. Science 262, 713–718
    OpenUrlAbstract/FREE Full Text
    1. Lemaire P.,
    2. Garrett N.,
    3. Gurdon J. B.
    (1995) Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell 81, 85–94
    OpenUrlCrossRefPubMedWeb of Science
    1. Lemaire P.,
    2. Kodjabachian L.
    (1996) The vertebrate organiser: structure and molecules. Trends Genet 12, 525–531
    OpenUrlCrossRefPubMedWeb of Science
    1. Mann R. S.
    (1995) The specificity of homeotic gene function. BioEssays 17, 855–863
    OpenUrlCrossRefPubMedWeb of Science
    1. Matsuo I.,
    2. Kuratani S.,
    3. Kimura C.,
    4. Takeda N.,
    5. Aizawa S.
    (1995) Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev 9, 2646–2658
    OpenUrlAbstract/FREE Full Text
    1. McCrea P.,
    2. Turck C. W.,
    3. Gumbiner B.
    (1991) A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 254, 1359–1361
    OpenUrlAbstract/FREE Full Text
    1. Miller J. R.,
    2. Moon R. T.
    (1996) Signal transduction through-catenin and specification of cell fate during embryogenesis. Genes Dev 10, 2527–2539
    OpenUrlFREE Full Text
    1. Molenaar M.,
    2. van de Wetering M.,
    3. Oosterwegel M.,
    4. Peterson-Maduro J.,
    5. Godsave S.,
    6. Korinek V.,
    7. Roose J.,
    8. Destree O.,
    9. Clevers H.
    (1996) XTcf-3 transcription factor mediates-catenin-induced axis formation in Xenopus embryos. Cell 86, 391–399
    OpenUrlCrossRefPubMedWeb of Science
    1. Newport J.,
    2. Kirschner M.
    (1982) A major developmental transition in early Xenopus embryos: I. Characterization and timing of cellular changes at the midblastula stage. Cell 30, 675–686
    OpenUrlCrossRefPubMedWeb of Science
    1. Pannese M.,
    2. Polo C.,
    3. Andreazzoli M.,
    4. Vignali R.,
    5. Kablar B.,
    6. Barsacchi G.,
    7. Boncinelli E.
    (1995) The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. Development 121, 707–720
    OpenUrlAbstract
    1. Pierce S. B.,
    2. Kimelman D.
    (1996) Overexpression of Xgsk-3 disrupts anterior ectodermal patterning in Xenopus. Dev. Biol 175, 256–264
    OpenUrlCrossRefPubMed
    1. Ryan K.,
    2. Garrett N.,
    3. Mitchell A.,
    4. Gurdon J. B.
    (1996) Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Cell 87, 989–1000
    OpenUrlCrossRefPubMedWeb of Science
    1. Sasai Y.,
    2. Lu B.,
    3. Steinbeisser H.,
    4. Geissert D.,
    5. Gont L. K.,
    6. De Robertis E. M.
    (1994) Xenopus chordin, a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79, 779–790
    OpenUrlCrossRefPubMedWeb of Science
    1. Sasai Y.,
    2. Lu B.,
    3. Piccolo S.,
    4. De Robertis E. M.
    (1996) Endoderminduction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. EMBO J 15, 4547–4555
    OpenUrlPubMedWeb of Science
    1. Sater A. K.,
    2. Jacobson A. G.
    (1990) The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis. Development 108, 461–470
    OpenUrlAbstract
    1. Schier A. F.,
    2. Gehring W. J.
    (1993) Functional specificity of the homeodomain protein fushi tarazu: The role of DNA-binding specificity in vivo. Proc. Natl. Acad. Sci. USA 90, 1450–1454
    OpenUrlAbstract/FREE Full Text
    1. Schneider S.,
    2. Steinbeisser H.,
    3. Warga R. M.,
    4. Hausen P.
    (1996) -catenin translocation into nuclei demarcates the dorsalizing centers of frog and fish embryos. Mech. Dev 57, 191–198
    OpenUrlCrossRefPubMedWeb of Science
    1. Shawlot W.,
    2. Behringer R. R.
    (1995) Requirement for Lim1 in head-organizer function. Nature 374, 425–430
    OpenUrlCrossRefPubMed
    1. Smith J. C.,
    2. Price B. M. J.,
    3. Green J. B. A.,
    4. Weigel D.,
    5. Herrmann B. G.
    (1991) Expression of a Xenopus homolog of brachyury (T) is an immediate-early response to mesoderm induction. Cell 67, 79–87
    OpenUrlCrossRefPubMedWeb of Science
    1. Smith W. C.,
    2. Harland R. M.
    (1992) Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 70, 829–840
    OpenUrlCrossRefPubMedWeb of Science
    1. Smith W. C.,
    2. McKendry R.,
    3. Ribisi S., Jr.,
    4. Harland R. M.
    (1995) A nodal -related gene defines a physical and functional domain within the Spemann organizer. Cell 82, 37–46
    OpenUrlCrossRefPubMedWeb of Science
    1. Sokol S. Y.,
    2. Melton D. A.
    (1992) Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus. Dev. Biol 154, 348–355
    OpenUrlCrossRefPubMedWeb of Science
    1. Taira M.,
    2. Jamrich M.,
    3. Good P. J.,
    4. Dawid I. B.
    (1992) The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Genes Dev 6, 365–366
    1. Talbot W. S.,
    2. Trevarrow B.,
    3. Halpern M. E.,
    4. Melby A. E.,
    5. Farr G.,
    6. Postlethwait J. H.,
    7. Jowett T.,
    8. Kimmel C. B.,
    9. Kimelman D.
    (1995) A homeobox gene essential for zebrafish notochord development. Nature 378, 150–157
    OpenUrlCrossRefPubMed
    1. Treisman J.,
    2. Gönczy P.,
    3. Vashishtha M.,
    4. Harris E.,
    5. Desplan C.
    (1989) A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell 59, 553–562
    OpenUrlCrossRefPubMedWeb of Science
    1. Vleminckx K.,
    2. Wong E.,
    3. Guger K.,
    4. Rubinfeld B.,
    5. Polakis P.,
    6. Gumbiner B. M.
    (1997) Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis. J. Cell Biol 136, 411–420
    OpenUrlAbstract/FREE Full Text
    1. Watabe T.,
    2. Kim S.,
    3. Candia A.,
    4. Rothbächer U.,
    5. Hashimoto C.,
    6. Inoue K.,
    7. Cho K. W. Y.
    (1995) Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev 9, 3038–3050
    OpenUrlAbstract/FREE Full Text
    1. Weinstein D. C.,
    2. Ruiz i Altaba A.,
    3. Chen W. S.,
    4. Hoodless P.,
    5. Prezioso V. R.,
    6. Jessell T. M.,
    7. Darnell J. E., Jr.
    (1994) The winged-helix transcription factor HNF-3 is required for notochord development in the mouse embryo. Cell 78, 575–588
    OpenUrlCrossRefPubMedWeb of Science
    1. Wilson D.,
    2. Sheng G.,
    3. Lecuit T.,
    4. Dostatni N.,
    5. Desplan C.
    (1993) Cooperative dimerization of Paired class homeodomains on DNA. Genes Dev 7, 2120–2134
    OpenUrlAbstract/FREE Full Text
    1. Wylie C.,
    2. Kofron M.,
    3. Payne C.,
    4. Anderson R.,
    5. Hosobuchi M.,
    6. Joseph E.,
    7. Heasman J.
    (1996) Maternal-catenin establishes a ‘dorsal signal’ in early Xenopus embryos. Development 122, 2987–2996
    OpenUrlAbstract
    1. Yang-Snyder J.,
    2. Miller J. R.,
    3. Brown J. D.,
    4. Lai C.-J.,
    5. Moon R. T.
    (1996) A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol 6, 1302–1306
    OpenUrlCrossRefPubMedWeb of Science
    1. Zhou X.,
    2. Sasaki H.,
    3. Lowe L.,
    4. Hogan B. L. M.,
    5. Kuehn M. R.
    (1993) Nodal is a novel TGF-like gene expressed in the mouse node during gastrulation. Nature 361, 543–547
    OpenUrlCrossRefPubMed
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JOURNAL ARTICLES
A role for Siamois in Spemann organizer formation
M.J. Fan, S.Y. Sokol
Development 1997 124: 2581-2589;
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JOURNAL ARTICLES
A role for Siamois in Spemann organizer formation
M.J. Fan, S.Y. Sokol
Development 1997 124: 2581-2589;

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