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JOURNAL ARTICLES
Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo
B. Oh, S.Y. Hwang, D. Solter, B.B. Knowles
Development 1997 124: 493-503;
B. Oh
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S.Y. Hwang
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D. Solter
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B.B. Knowles
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Summary

Timely translation of maternal transcripts and post-translational modification of their gene products control the initial development of preimplantation-stage embryos. We have isolated and characterized a gene encoding a stage-specific embryonic protein. This novel gene, spindlin (Spin), is an abundant maternal transcript present in the unfertilized egg and 2-cell, but not 8-cell, stage embryo. Spin exhibits high homology to a multicopy gene, Y-linked spermiogenesis-specific transcript (Ssty), and together they form a new gene family expressed during gametogenesis. We find that spindlin associates with the meiotic spindle and is modified by phosphorylation in a cell-cycle-dependent fashion. Furthermore, it comigrates with the previously described 30x10(3) Mr metaphase complex which is posttranslationally modified during the first mitotic cell cycle. Our data suggest that spindlin plays a role in cell-cycle regulation during the transition from gamete to embryo.

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JOURNAL ARTICLES
Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo
B. Oh, S.Y. Hwang, D. Solter, B.B. Knowles
Development 1997 124: 493-503;
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JOURNAL ARTICLES
Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo
B. Oh, S.Y. Hwang, D. Solter, B.B. Knowles
Development 1997 124: 493-503;

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