Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in
  • Log out

Search

  • Advanced search
Development
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Development

  • Log in
Advanced search

RSS  Twitter  Facebook  YouTube 

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
JOURNAL ARTICLES
Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis
W.M. Deng, M. Bownes
Development 1997 124: 4639-4647;
W.M. Deng
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Bownes
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & metrics
  • PDF
Loading

Summary

The Drosophila eggshell, which has a pair of chorionic appendages (dorsal appendages) located asymmetrically along both the anterior/posterior and dorsal/ventral axes, provides a good model to study signal instructed morphogenesis. We show that the Broad-Complex, a gene encoding zinc-finger transcription factors, is essential for the morphogenesis of dorsal appendages and is expressed in a bilaterally symmetrical pattern in the lateral-dorsal-anterior follicle cells during late oogenesis. This is induced and specified along the dorsoventral axis by an epidermal growth factor receptor signalling pathway, which includes a localised transforming growth factor-alpha like molecule, Gurken, in the oocyte and the Drosophila EGF receptor homologue, Torpedo, in the surrounding somatic follicle cells. Furthermore, the precisely localised expression of BR-C along the AP axis requires a separate signalling pathway, initiated by a transforming growth factor-beta homologue, Decapentaplegic, in nearby follicle cells. These two signalling pathways, one from the oocyte and the other from the follicle cells, co-ordinately specify patches of follicle cells to express the Broad-Complex in a unique position in respect to both major axes, which in turn directs the differentiation of the dorsal appendages in the correct position on the eggshell.

REFERENCES

    1. Bardwell V. J.,
    2. Treisman R.
    (1994) The POZ domain: A conserved protein-protein interaction motif. Genes Dev 8, 1664–1677
    OpenUrlAbstract/FREE Full Text
    1. Bayer C. A.,
    2. Holley B.,
    3. Fristrom J. W.
    (1996) A switch in broad-complex zinc-finger isoform expression is regulated posttranscriptionally during the metamorphosis of Drosophila imaginal discs. Dev. Biol 177, 1–14
    OpenUrlCrossRefPubMedWeb of Science
    1. Bayer C. A.,
    2. von Kalm L.,
    3. Fristrom J. W.
    (1997) Relationship between protein isoforms and genetic functions demonstrate functional redundancy at Broad-Complex during Drosophila metamorphosis. Dev. Biol 187, 267–282
    OpenUrlCrossRefPubMedWeb of Science
    1. Belyaeva E. S.,
    2. Aizenzon M. G.,
    3. Semeshin V. F.,
    4. Kiss I.,
    5. Koczya K.,
    6. Baritcheva M.,
    7. Goraelova T. D.,
    8. Zhimulev I.
    (1980) Cytogenetic analyses of the 2B3/4-2B11 region of the X-chromosome of Drosophila melanogaster. I. Cytology of the region and mutant complementation groups. Chromosoma 81, 281–306
    OpenUrlCrossRefPubMedWeb of Science
    1. Brand A. H.,
    2. Perrimon N.
    (1994) Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev 8, 629–639
    OpenUrlAbstract/FREE Full Text
    1. Brand A.H.,
    2. Perrimon N.
    (1993) Targeted gene expression as a means ofaltering cell fates and generating dominant phenotypes. Development 118, 401–415
    OpenUrlAbstract
    1. Brunner D.,
    2. Ducker K.,
    3. Oellers N.,
    4. Hafen E.,
    5. Scholz H.,
    6. Klämbt C.
    (1994) The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway. Nature 370, 386–389
    OpenUrlCrossRefPubMedWeb of Science
    1. Cheung H. K.,
    2. Serano T. L.,
    3. Cohen R. S.
    (1992) Evidence for a highly selective RNA transport system and its role in establishing the dorsoventral axis of the Drosophila egg. Development 114, 653–661
    OpenUrlAbstract
    1. Christenson L. B.,
    2. McKearin D. M.
    (1994) Orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis. Genes Dev 8, 614–628
    OpenUrlAbstract/FREE Full Text
    1. De Celis J. F.,
    2. Barrio R.,
    3. Kafatos F. C.
    (1996) A gene complex acting downstream of dpp in Drosophila wing morphogenesis. Nature 381, 421–424
    OpenUrlCrossRefPubMed
    1. DiBello P. R.,
    2. Withers D. A.,
    3. Bayer C. A.,
    4. Fristrom J. W.,
    5. Guild G. M.
    (1991) The DrosophilaBroad-Complex encodes a family of related proteins containing zinc fingers. Genetics 129, 385–97
    OpenUrlAbstract/FREE Full Text
    1. Edwards K. A.,
    2. Kiehart D. P.
    (1996) Drosophila nonmuscle myosin-II has multiple essential roles in imaginal disc and egg chamber morphogenesis. Development 122, 1499–1511
    OpenUrlAbstract
    1. Emery I. F.,
    2. Bedian V.,
    3. Guild G. M.
    (1994) Differential expression of Broad-Complex transcription factors may forecast distinct developmental tissue fates during Drosophila metamorphosis. Development 120, 3275–3287
    OpenUrlAbstract
    1. González-Reyes A.,
    2. Elliott H.,
    3. St Johston D.
    (1995) Polarization of both major body axes in Drosophila by gurken-torpedo signalling. Nature 375, 654–658
    OpenUrlCrossRefPubMedWeb of Science
    1. Gotwals B.,
    2. Fristrom J. W.
    (1991) Three neighbouring genes interacting with Broad-Complex and the Stubble-stubboid locus to affect imaginal disc morphogenesis in Drosophila. Genetics 127, 747–759
    OpenUrlAbstract/FREE Full Text
    1. Henrich V. C.,
    2. Livingston L.,
    3. Gilbert L. I.
    (1993) Developmental requirements for the ecdysoneless (ecd) locus in Drosophilamelanogaster. Dev. Genet 14, 369–77
    OpenUrlCrossRefPubMedWeb of Science
    1. Hsu T.,
    2. Bagni C. J.,
    3. Sutherland D.,
    4. Kafatos F. C.
    (1996) The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. Genes Dev 10, 1411–1421
    OpenUrlAbstract/FREE Full Text
    1. Huang R. Y.,
    2. Orr W. C.
    (1992) Broad-Complex function during oogenesis in Drosophilamelanogaster. Dev. Genet 13, 277–88
    OpenUrlCrossRefPubMed
    1. Karim F. D.,
    2. Guild G. M.,
    3. Thummel C. S.
    (1993) The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis. Development 118, 977–988
    OpenUrlAbstract
    1. Kiss I.,
    2. Beaton A. H.,
    3. Tardiff J.,
    4. Fristrom D.,
    5. Fristrom J. W.
    (1988) Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster. Genetics 118, 247–59
    OpenUrlAbstract/FREE Full Text
    1. Klaes A.,
    2. Menne T.,
    3. Stollewerk A.,
    4. Schloz H.,
    5. Klämbt C.
    (1994) The ETS transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS. Cell 78, 149–160
    OpenUrlCrossRefPubMedWeb of Science
    1. Klämbt C.
    (1993) The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117, 163–176
    OpenUrlAbstract/FREE Full Text
    1. Lecuit T.,
    2. Brook W. J.,
    3. Ng M.,
    4. Calleja M.,
    5. Sun H.,
    6. Cohen S. M.
    (1996) Two distinct mechanisms for long-range patterning by decapentaplegic in the Drosophila wing. Nature 381, 387–393
    OpenUrlCrossRefPubMedWeb of Science
    1. Lu X.,
    2. Melnick M. B.,
    3. Hsu J. C.,
    4. Perrimon N.
    (1994) Genetic and molecular analysis of mutations involved in Drosophila Raf signal transduction. EMBO J 13, 2592–2599
    OpenUrlPubMedWeb of Science
    1. Manseau L. J.,
    2. Schupbach T.
    (1989) cappuccino and spire: Two unique maternal effect loci required for both the anterioposterior and dorsoventral patterns of the Drosophila embryo. Genes Dev 3, 1437–1452
    OpenUrlAbstract/FREE Full Text
    1. Morimoto A. M.,
    2. Jordan K. C.,
    3. Tietze. K.,
    4. Britton J. S.,
    5. O'Neill E. M.,
    6. Ruohola-Baker H.
    (1996) Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis. Development 122, 3745–3754
    OpenUrlAbstract
    1. Neuman-Silberberg F. S.,
    2. Schupbach T.
    (1994) Dorsoventral axis formation in Drosophila depends on the correct dosage of the gene gurken. Development 120, 2457–2463
    OpenUrlAbstract/FREE Full Text
    1. Neuman-Silberberg F. S.,
    2. Schupbach T.
    (1993) The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein. Cell 75, 165–174
    OpenUrlCrossRefPubMedWeb of Science
    1. Padgett R. W.,
    2. St. Johnston R. D.,
    3. Gelbart W. M.
    (1987) A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family. Nature 325, 81–84
    OpenUrlCrossRefPubMed
    1. Price J. V.,
    2. Clifford R. J.,
    3. Schupbach T.
    (1989) The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56, 1085–1092
    OpenUrlCrossRefPubMed
    1. Roth S.,
    2. Schupbach T.
    (1994) The relationship between ovarian and embryonic dorsoventral patterning in Drosophila. Development 120, 2245–2257
    OpenUrlAbstract
    1. Roth S.,
    2. Neuman-Silberberg F. S.,
    3. Barcelo G.,
    4. Schupbach T.
    (1995) cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. Cell 81, 967–978
    OpenUrlCrossRefPubMedWeb of Science
    1. Ruohola-Baker H.,
    2. Grell E.,
    3. Chou T.-B.,
    4. Baker D.,
    5. Jan L. Y.,
    6. Jan Y. N.
    (1993) Spatially localized Rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis. Cell 73, 953–965
    OpenUrlCrossRefPubMedWeb of Science
    1. Schnorr J.,
    2. Berg C. A.
    (1996) Differential activity of Ras1 during patterning of the Drosophila dorsoventral axis. Genetics 144, 1545–1557
    OpenUrlAbstract/FREE Full Text
    1. Schupbach T.
    (1987) Germ line and soma co-operate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster. Cell 49, 699–707
    OpenUrlCrossRefPubMedWeb of Science
    1. Staehling-Hampton K.,
    2. Hoffmann F. M.
    (1994) Ectopic decapentaplegic in the Drosophila midgut alters the expression of five homeotic genes, dpp, and wingless, causing specific morphological defects. Dev. Biol 164, 502–512
    OpenUrlCrossRefPubMedWeb of Science
    1. Talbot W. S.,
    2. Swyryd E. A.,
    3. Hogness D. S.
    (1993) Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell 73, 1323–1337
    OpenUrlCrossRefPubMedWeb of Science
    1. Tautz D.,
    2. Pfeifle C.
    (1989) A nonradioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals a translational control of the segmentation gene hunchback. Chromosoma 98, 81–85
    OpenUrlCrossRefPubMedWeb of Science
    1. Twombly V.,
    2. Blackman R. K.,
    3. Jin H.,
    4. Graff J. M.,
    5. Padgett R. W.,
    6. Gelbart W. M.
    (1996) The TGF-signaling pathway is essential for Drosophila oogenesis. Development 122, 1555–1565
    OpenUrlAbstract
Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

 Download PDF

Email

Thank you for your interest in spreading the word on Development.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis
(Your Name) has sent you a message from Development
(Your Name) thought you would like to see the Development web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
JOURNAL ARTICLES
Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis
W.M. Deng, M. Bownes
Development 1997 124: 4639-4647;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
JOURNAL ARTICLES
Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis
W.M. Deng, M. Bownes
Development 1997 124: 4639-4647;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
  • Info & metrics
  • PDF

Related articles

Cited by...

More in this TOC section

  • A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development
  • Visualization and functional characterization of the developing murine cardiac conduction system
  • Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
Show more JOURNAL ARTICLES

Similar articles

Other journals from The Company of Biologists

Journal of Cell Science

Journal of Experimental Biology

Disease Models & Mechanisms

Biology Open

Advertisement

Kathryn Virginia Anderson (1952-2020)

Developmental geneticist Kathryn Anderson passed away at home on 30 November 2020. Tamara Caspary, a former postdoc and friend, remembers Kathryn and her remarkable contribution to developmental biology.


Zooming into 2021

In a new Editorial, Editor-in-Chief James Briscoe and Executive Editor Katherine Brown reflect on the triumphs and tribulations of the last 12 months, and look towards a hopefully calmer and more predictable year.


Read & Publish participation extends worldwide

Over 60 institutions in 12 countries are now participating in our Read & Publish initiative. Here, James Briscoe explains what this means for his institution, The Francis Crick Institute. Find out more and view our full list of participating institutions.


Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.


Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Sign up to join our next session:

10 February
Time: 13:00 (GMT)
Chaired by: preLights

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Sign up for alerts

About us

  • About Development
  • About the Node
  • Editors and board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact Development
  • Subscriptions
  • Advertising
  • Feedback

 Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992