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JOURNAL ARTICLES
Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6
D. Caric, D. Gooday, R.E. Hill, S.K. McConnell, D.J. Price
Development 1997 124: 5087-5096;

Summary

The cerebral cortex forms by the orderly migration and subsequent differentiation of neuronal precursors generated in the proliferative ventricular zone. We studied the role of the transcription factor Pax-6, which is expressed in the ventricular zone, in cortical development. Embryos homozygous for a mutation of Pax-6 (Small eye; Sey) had abnormalities suggesting defective migration of late-born cortical precursors. When late-born Sey/Sey precursors were transplanted into wild-type embryonic rat cortex, they showed similar integrative, migrational and differentiative abilities to those of transplanted wild-type mouse precursors. These results suggest that postmitotic cortical cells do not need Pax-6 to acquire the capacity to migrate and differentiate, but that Pax-6 generates a cortical environment that permits later-born precursors to express their full developmental potential.

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JOURNAL ARTICLES
Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6
D. Caric, D. Gooday, R.E. Hill, S.K. McConnell, D.J. Price
Development 1997 124: 5087-5096;
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