Advertisement
JOURNAL ARTICLES
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
M.J. Solloway, E.J. Robertson
Development 1999 126: 1753-1768;

Summary

Members of the BMP family of signaling molecules display a high conservation of structure and function, and multiple BMPs are often coexpressed in a variety of tissues during development. Moreover, distinct BMP ligands are capable of activating common pathways. Here we describe the coexpression of two members of the 60A subfamily of BMPs, Bmp5 and Bmp7, at a number of different sites in the embryo from gastrulation onwards. Previous studies demonstrate that loss of either Bmp5 or Bmp7 has negligible effects on development, suggesting these molecules functionally compensate for each other at early stages of embryonic development. Here we show this is indeed the case. Thus we find that Bmp5;Bmp7 double mutants die at 10.5 dpc and display striking defects primarily affecting the tissues where these factors are coexpressed. The present analysis also uncovers novel roles for BMP signaling during the development of the allantois, heart, branchial arches, somites and forebrain. Bmp5 and Bmp7 do not appear to be involved in establishing pattern in these tissues, but are instead necessary for the proliferation and maintenance of specific cell populations. These findings are discussed with respect to potential mechanisms underlying cooperative signaling by multiple members of the TGF-beta superfamily.

Reference

    1. Arkell R.,
    2. Beddington R. S. P.
    (1997) BMP-7 influences pattern and growth of the developing hindbrain of mouse embryos. Development 124, 1–12
    OpenUrlAbstract
    1. Arora K.,
    2. Levine M. S.,
    3. O'Connor M. B.
    (1994) The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo. Genes Dev 8, 2588–2601
    OpenUrlAbstract/FREE Full Text
    1. Bellusci S.,
    2. Henderson R.,
    3. Winnier G.,
    4. Oikawa T.,
    5. Hogan B. L.
    (1996) Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122, 1693–1702
    OpenUrlAbstract
    1. Bronner-Fraser M.
    (1986) Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1. Dev. Biol 115, 44–55
    OpenUrlCrossRefPubMedWeb of Science
    1. Capdevila J.,
    2. Johnson R. L.
    (1998) Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning. Dev. Biol 197, 205–217
    OpenUrlCrossRefPubMedWeb of Science
    1. Chen Y.,
    2. Riese M. J.,
    3. Killinger M. A.,
    4. Hoffmann F. M.
    (1998) A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. Development 125, 1759–1768
    OpenUrlAbstract
    1. Chen Z. F.,
    2. Behringer R. R.
    (1995) twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev 9, 686–699
    OpenUrlAbstract/FREE Full Text
    1. Conlon R. A.,
    2. Reaume A. G.,
    3. Rossant J.
    (1995) Notch1 is required for the coordinate segmentation of the somites. Development 121, 1533–1545
    OpenUrlAbstract
    1. Dewulf N.,
    2. Verschueren K.,
    3. Lonnoy O.,
    4. Moren A.,
    5. Grimsby S.,
    6. Vande Spiegle K.,
    7. Miyazono K.,
    8. Huylebroeck D.,
    9. ten Dijke P.
    (1995) Distinct spatial and temporal patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. Endo 136, 2652–2653
    OpenUrlCrossRefPubMedWeb of Science
    1. Dudley A. T.,
    2. Lyons K. M.,
    3. Robertson E. J.
    (1995) A requirement for bone morphogenetic protein-7 during development of the mouse mammalian kidney and eye. Genes Dev 9, 2795–2807
    OpenUrlAbstract/FREE Full Text
    1. Dudley A. T.,
    2. Robertson E. J.
    (1997) Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev. Dyn 208, 349–362
    OpenUrlCrossRefPubMedWeb of Science
    1. Echelard Y.,
    2. Epstein D. J.,
    3. St-Jacques B.,
    4. Shen L.,
    5. Mohler J.,
    6. McMahon J. A.,
    7. McMahon A. P.
    (1993) Sonic Hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417–1430
    OpenUrlCrossRefPubMedWeb of Science
    1. Ferguson E. L.,
    2. Anderson K. V.
    (1992) Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71, 451–461
    OpenUrlCrossRefPubMedWeb of Science
    1. Fishman M. C.,
    2. Chien K. R.
    (1997) Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099–2117
    OpenUrlAbstract
    1. Fuchtbauer E. M.
    (1995) Expression of M-twist during postimplantation development of the mouse. Dev. Dyn 204, 316–322
    OpenUrlCrossRefPubMedWeb of Science
    1. Furuta Y.,
    2. Piston D. W.,
    3. Hogan B. L.
    (1997) Bone Morphogenetic Proteins (BMP's) as regulators of dorsal forebrain development. Development 124, 2203–2212
    OpenUrlAbstract
    1. Gañan Y.,
    2. Macias D.,
    3. Duterque-Coquillaud M.,
    4. Ros M. A.,
    5. Hurle J. M.
    (1996) Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod. Development 122, 2349–2357
    OpenUrlAbstract
    1. Geelen J. A.,
    2. Langman J.
    (1977) Closure of the neural tube in the cephalic region of the mouse embryo. Anat. Rec 189, 625–640
    OpenUrlCrossRefPubMed
    1. Goulding M. D.,
    2. Chalepakis G.,
    3. Detsch U.,
    4. Erselius J. R.,
    5. Gruss P.
    (1991) Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBOJ 10, 1135–1147
    OpenUrlPubMedWeb of Science
    1. Graham A.,
    2. Francis-West P.,
    3. Brickell P.,
    4. Lumsden A.
    (1994) The signaling molecule BMP-4 mediates apoptosis in the rhombencephalic neural crest. Nature 372, 684–686
    OpenUrlCrossRefPubMed
    1. Green E. L.,
    2. Green M. C.
    (1942) The Development of Three Manifestations of the Short Ear Gene in the Mouse. J. Morphol 70, 1–19
    OpenUrlCrossRef
    1. Green M. C.
    (1951) Further morphological effects of the short ear gene in the house mouse. J. Morphol 88, 1–21
    OpenUrlCrossRef
    1. Green J. B.,
    2. New H. V.,
    3. Smith J. C.
    (1992) Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71, 731–739
    OpenUrlCrossRefPubMedWeb of Science
    1. Gurdon J. B.,
    2. Harger P.,
    3. Mitchell A.,
    4. Lemaire P.
    (1994) Activin signalling and response to a morphogen gradient. Nature 371, 487–492
    OpenUrlCrossRefPubMed
    1. Gurtner G. C.,
    2. Davis V.,
    3. Li H.,
    4. McCoy M. J.,
    5. Sharpe A.,
    6. Cybulsky M. I.
    (1995) Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev 9, 1–14
    OpenUrlAbstract/FREE Full Text
    1. Hata A.,
    2. Lo R. S.,
    3. Wotton D.,
    4. Lagna G.,
    5. Massague J.
    (1997) Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388, 82–87
    OpenUrlCrossRefPubMedWeb of Science
    1. Heikinheimo M.,
    2. Lawshe A.,
    3. Shackleford G. M.,
    4. Wilson D. B.,
    5. MacArthur C. A.
    (1994) Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs, and central nervous system. Mech. Dev 48, 129–138
    OpenUrlCrossRefPubMedWeb of Science
    1. Hirsinger E.,
    2. Duprez D.,
    3. Jouve C.,
    4. Malapert P.,
    5. Cooke J.,
    6. Pourquie O.
    (1997) Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning. Development 124, 4605–4614
    OpenUrlAbstract
    1. Hogan B. L. M.
    (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10, 1580–1594
    OpenUrlFREE Full Text
    1. Ikeda T.,
    2. Takahashi H.,
    3. Suzuki A.,
    4. Ueno N.,
    5. Yokose S.,
    6. Yamaguchi A.,
    7. Yoshiki S.
    (1996) Cloning of rat type I receptor cDNA for Bone Morphogenetic Protein-2 and Bone Morphogenetic Protein-4, and the localization compared with that of the ligands. Dev. Dyn 206, 318–329
    OpenUrlCrossRefPubMedWeb of Science
    1. Jeffs P.,
    2. Osmond M.
    (1992) A segmented pattern of cell death during development of the chick embryo. Anat. Embryol. (Berl) 185, 589–598
    OpenUrlPubMed
    1. Khalsa O.,
    2. Yoon J. W.,
    3. Torres-Schumann S.,
    4. Wharton K. A.
    (1998) TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing. Development 125, 2723–2734
    OpenUrlAbstract
    1. King J. A.,
    2. Marker P. C.,
    3. Seung K. J.,
    4. Kingsley D. M.
    (1994) BMP5and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev. Biol 166, 112–122
    OpenUrlCrossRefPubMedWeb of Science
    1. Kingsley D. M.,
    2. Bland A. E.,
    3. Grubber J. M.,
    4. Marker P. C.,
    5. Russell L. B.,
    6. Copeland N. G.,
    7. Jenkins N.
    (1992) The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFSuperfamily. Cell 71, 399–410
    OpenUrlCrossRefPubMedWeb of Science
    1. Kretzschmar M.,
    2. Doody J.,
    3. Massague J.
    (1997) Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389, 618–622
    OpenUrlCrossRefPubMedWeb of Science
    1. Kretzschmar M.,
    2. Massague J.
    (1998) SMADs: mediators and regulators of TGF-beta signaling. Curr. Opin. Genet. Dev 8, 103–111
    OpenUrlCrossRefPubMedWeb of Science
    1. Kubalak S. W.,
    2. Miller-Hance W. C.,
    3. O'Brien T. X.,
    4. Dyson E.,
    5. Chien K. R.
    (1994) Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J. Biol. Chem 269, 16961–70
    OpenUrlAbstract/FREE Full Text
    1. Kwee L.,
    2. Baldwin H. S.,
    3. Shen H. M.,
    4. Stewart C. L.,
    5. Buck C.,
    6. Buck C. A.,
    7. Labow M. A.
    (1995) Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121, 489–503
    OpenUrlAbstract
    1. Liem K. F.,
    2. Tremml G.,
    3. Roelink H.,
    4. Jessell T. M.
    (1995) Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82, 969–979
    OpenUrlCrossRefPubMedWeb of Science
    1. Liem K. F. J.,
    2. Tremml G.,
    3. Jessell T. M.
    (1997) A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord. Cell 91, 127–138
    OpenUrlCrossRefPubMedWeb of Science
    1. Luo G.,
    2. Hofmann C.,
    3. Bronckers A. L. J. J.,
    4. Sohocki M.,
    5. Bradley A.,
    6. Karsenty G.
    (1995) BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9, 2808–2820
    OpenUrlAbstract/FREE Full Text
    1. Luo K.,
    2. Lodish H. F.
    (1996) Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction. EMBO J 15, 4485–4496
    OpenUrlPubMedWeb of Science
    1. Lyons K. M.,
    2. Hogan B. L. M.,
    3. Robertson E. J.
    (1995) Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. Mech. Dev 50, 71–83
    OpenUrlCrossRefPubMedWeb of Science
    1. Marcelle C.,
    2. Stark M. R.,
    3. Bronner-Fraser M.
    (1997) Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite. Development 124, 3955–3963
    OpenUrlAbstract
    1. Massague J.
    (1998) TGF-beta signal transduction. Annu. Rev. Biochem 67, 753–791
    OpenUrlCrossRefPubMedWeb of Science
    1. McMahon J. A.,
    2. Takada S.,
    3. Zimmerman L. B.,
    4. Fan C. M.,
    5. Harland R. M.,
    6. McMahon A. P.
    (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 12, 1438–1452
    OpenUrlAbstract/FREE Full Text
    1. Mishina Y.,
    2. Suzuki A.,
    3. Ueno N.,
    4. Behringer R. R.
    (1995) Bmpr encodes a type I Bone morhogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev 9, 3027–3037
    OpenUrlAbstract/FREE Full Text
    1. Mitchell P. J.,
    2. Timmons P. M.,
    3. Hebert J. M.,
    4. Rigby P. W.,
    5. Tjian R.
    (1991) Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev 5, 105–119
    OpenUrlAbstract/FREE Full Text
    1. Nakao A.,
    2. Imamura T.,
    3. Souchelnytskyi S.,
    4. Kawabata M.,
    5. Ishisaki A.,
    6. Oeda E.,
    7. Tamaki K.,
    8. Hanai J.,
    9. Heldin C. H.,
    10. Miyazono K.,
    11. ten Dijke P.
    (1997) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16, 5353–5362
    OpenUrlAbstract
    1. Neul J. L.,
    2. Ferguson E. L.
    (1998) Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning. Cell 95, 483–494
    OpenUrlCrossRefPubMedWeb of Science
    1. Nguyen M.,
    2. Park S.,
    3. Marques G.,
    4. Arora K.
    (1998) Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV. Cell 95, 495–506
    OpenUrlCrossRefPubMedWeb of Science
    1. Nishimatsu S.,
    2. Thomsen G. H.
    (1998) Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos. Mech. Dev 74, 75–88
    OpenUrlCrossRefPubMedWeb of Science
    1. Parr B. A.,
    2. Shea M. J.,
    3. Vassileva G.,
    4. McMahon A. P.
    (1993) Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development 119, 247–261
    OpenUrlAbstract
    1. Pourquie O.,
    2. Fan C. M.,
    3. Coltey M.,
    4. Hirsinger E.,
    5. Watanabe Y.,
    6. Breant C.,
    7. Francis-West P.,
    8. Brickell P.,
    9. Tessier-Lavigne M.,
    10. Le Douarin N. M.
    (1996) Lateral and axial signals involved in avian somite patterning: a role for BMP4. Cell 84, 461–471
    OpenUrlCrossRefPubMedWeb of Science
    1. Raftery L. A.,
    2. Twombly V.,
    3. Wharton K.,
    4. Gelbart W. M.
    (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139, 241–254
    OpenUrlAbstract/FREE Full Text
    1. Reshef R.,
    2. Maroto M.,
    3. Lassar A. B.
    (1998) Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. Genes Dev 12, 290–303
    OpenUrlAbstract/FREE Full Text
    1. Schluter G.
    (1973) Ultrastructural observations on cell necrosis during formation of the neural tube in mouse embryos. Z. Anat. Entwicklungsgesch 141, 251–264
    OpenUrlCrossRefPubMedWeb of Science
    1. Shah N. M.,
    2. Groves A. L.,
    3. Anderson D. J.
    (1996) Alternative neural crest cell fates are instructively promoted by TGFsuperfamily members. Cell 85, 331–344
    OpenUrlCrossRefPubMedWeb of Science
    1. Shi Y.,
    2. Hata A.,
    3. Lo R. S.,
    4. Massague J.,
    5. Pavletich N. P.
    (1997) A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388, 87–93
    OpenUrlCrossRefPubMedWeb of Science
    1. Shimamura K.,
    2. Rubenstein J. L.
    (1997) Inductive interactions direct early regionalization of the mouse forebrain. Development 124, 2709–2718
    OpenUrlAbstract
    1. Solloway M. J.,
    2. Dudley A. T.,
    3. Bikoff E. K.,
    4. Lyons K. M.,
    5. Hogan B. L.,
    6. Robertson E. J.
    (1998) Mice lacking Bmp6 function. Dev. Genet 22, 321–339
    OpenUrlCrossRefPubMedWeb of Science
    1. Song Q.,
    2. Mehler M. F.,
    3. Kessler J. A.
    (1998) Bone morphogenetic proteins induce apoptosis and growth factor dependence of cultured sympathoadrenal progenitor cells. Dev. Biol 196, 119–127
    OpenUrlCrossRefPubMedWeb of Science
    1. Stemple D. L.,
    2. Anderson D. J.
    (1992) Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell 71, 973–985
    OpenUrlCrossRefPubMedWeb of Science
    1. Suzuki A.,
    2. Kaneko E.,
    3. Maeda J.,
    4. Ueno N.
    (1997) Mesoderm induction by BMP-4 and-7 heterodimers. Biochem. Biophys. Res. Commun 232, 153–156
    OpenUrlCrossRefPubMedWeb of Science
    1. Tajbakhsh S.,
    2. Spörle R.
    (1998) Somite development: constructing the vertebrate body. Cell 92, 9–16
    OpenUrlCrossRefPubMed
    1. ten Dijke P.,
    2. Yamashita H.,
    3. Sampath T. K.,
    4. Reddi A. H.,
    5. Estevez M.,
    6. Riddle D. L.,
    7. Ichijo H.,
    8. Heldin C. H.,
    9. Miyazono K.
    (1994) Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J. Biol. Chem 269, 16985–16988
    OpenUrlAbstract/FREE Full Text
    1. Tonegawa A.,
    2. Funayama N.,
    3. Ueno N.,
    4. Takahashi Y.
    (1997) Mesodermal subdivision along the mediolateral axis in chicken controlled by different concentrations of BMP-4. Development 124, 1975–1984
    OpenUrlAbstract
    1. Vale W.,
    2. Rivier C.,
    3. Hsueh A.,
    4. Campen C.,
    5. Meunier H.,
    6. Bicsak T.,
    7. Vaughan J.,
    8. Corrigan A.,
    9. Bardin W.,
    10. Sawchenko P.,
    11. et al.
    (1988) Chemical and biological characterization of the inhibin family of protein hormones. Recent Prog. Horm. Res 44, 1–34
    1. Waldrip W. R.,
    2. Bikoff E. K.,
    3. Hoodless P. A.,
    4. Wrana J. L.,
    5. Robertson E. J.
    (1998) Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92, 797–808
    OpenUrlCrossRefPubMedWeb of Science
    1. Wall N. A.,
    2. Hogan B. L. M.
    (1995) Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick. Mech. Dev 53, 383–392
    OpenUrlCrossRefPubMedWeb of Science
    1. Weil M.,
    2. Jacobson M. D.,
    3. Raff M. C.
    (1997) Is programmed cell death required for neural tube closure?. Curr. Biol 7, 281–284
    OpenUrlCrossRefPubMedWeb of Science
    1. Winnier G.,
    2. Blessing M.,
    3. Labosky P. A.,
    4. Hogan B. L. M.
    (1995) Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 9, 2105–2116
    OpenUrlAbstract/FREE Full Text
    1. Yamashita H.,
    2. ten Dijke P.,
    3. Franzen P.,
    4. Miyazono K.,
    5. Heldin C. H.
    (1994) Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta. J. Biol. Chem 269, 20172–20178
    OpenUrlAbstract/FREE Full Text
    1. Yang J. T.,
    2. Rayburn H.,
    3. Hynes R. O.
    (1995) Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121, 549–560
    OpenUrlAbstract
    1. Zhang H.,
    2. Bradley A.
    (1996) Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122, 2977–2986
    OpenUrlAbstract
    1. Zhang J.,
    2. Hagopian-Donaldson S.,
    3. Serbedzija G.,
    4. Elsemore J.,
    5. Plehn-Dujowich D.,
    6. McMahon A. P.,
    7. Flavell R. A.,
    8. Williams T.
    (1996) Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 381, 238–241
    OpenUrlCrossRefPubMedWeb of Science
    1. Zhang Y.,
    2. Feng X.,
    3. We R.,
    4. Derynck R.
    (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383, 168–172
    OpenUrlCrossRefPubMedWeb of Science
    1. Zimmerman L. B.,
    2. De Jesus-Escobar J. M.,
    3. Harland R. M.
    (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86, 599–606
    OpenUrlCrossRefPubMedWeb of Science
Back to top

 Download PDF

Email
JOURNAL ARTICLES
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
M.J. Solloway, E.J. Robertson
Development 1999 126: 1753-1768;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Alerts

Article navigation

Other journals from The Company of Biologists

Advertisement

An interview with Swathi Arur

Swathi Arur joined the team at Development as an Academic Editor in 2020. Her lab uses multidisciplinary approaches to understand female germline development and fertility. We met with her over Zoom to hear more about her life, her career and her love for C. elegans.

Jim Wells and Hanna Mikkola join our team of Editors

We are pleased to welcome James (Jim) Wells and Hanna Mikkola to our team of Editors. Jim joins us a new Academic Editor, taking over from Gordan Keller, and Hanna joins our team of Associate Editors. Find out more about their research interests and areas of expertise.

New funding scheme supports sustainable events

As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.

Read & Publish participation continues to grow

“I’d heard of Read & Publish deals and knew that many universities, including mine, had signed up to them but I had not previously understood the benefits that these deals bring to authors who work at those universities.”

Professor Sally Lowell (University of Edinburgh) shares her experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 150 institutions in 15 countries and four library consortia taking part – find out more and view our full list of participating institutions.

Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.

Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Here, Brandon Carpenter talks about how inherited histone methylation defines the germline versus soma decision in C. elegans. 

Sign up to join our next session:

10 March
Time: TBC
Chaired by: Thomas Lecuit