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Research Article
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation
Yafeng Ma, Ang Li, William J. Faller, Silvana Libertini, Florencia Fiorito, David A. Gillespie, Owen J. Sansom, Shigeko Yamashiro, Laura M. Machesky
Development 2013 140: 2203-2211; doi: 10.1242/dev.089789
Yafeng Ma
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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Ang Li
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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William J. Faller
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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Silvana Libertini
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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Florencia Fiorito
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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David A. Gillespie
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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Owen J. Sansom
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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Shigeko Yamashiro
2 Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08855, USA.
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Laura M. Machesky
1 Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
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  • For correspondence: laura.machesky@glasgow.ac.uk
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Summary

Fascins, a family of actin-bundling proteins, are expressed in a spatially and temporally restricted manner during development and often in cancer. Fascin 1 has a clear role in cell migration in vitro, but its role in vivo in mammals is not well understood. Here, we investigate the role of fascin 1 in the melanocyte lineage and in melanoma cells. Fascin 1 knockout causes hypopigmentation in adult mice owing to migration and cell cycle progression defects in melanoblasts, the melanocyte precursor cell. Study of live embryo skin explants reveals that E14.5 fascin 1-null melanoblasts migrate slower, and generate fewer and thinner pseudopods. By contrast, fascin 1 expression drives faster migration and lamellipodia protrusion in melanocytes in vitro. In addition, fascin 1 depletion retards melanoblast proliferation in vivo and melanoma cell growth in vitro. These data indicate that fascin 1 not only promotes cell migration in mouse melanocytes but it also has a role in growth and cell cycle progression.

  • Accepted March 22, 2013.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Keywords

  • Fascin 1 (Fscn1)
  • Melanoblast
  • Migration
  • Mouse

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Research Article
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation
Yafeng Ma, Ang Li, William J. Faller, Silvana Libertini, Florencia Fiorito, David A. Gillespie, Owen J. Sansom, Shigeko Yamashiro, Laura M. Machesky
Development 2013 140: 2203-2211; doi: 10.1242/dev.089789
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Research Article
Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation
Yafeng Ma, Ang Li, William J. Faller, Silvana Libertini, Florencia Fiorito, David A. Gillespie, Owen J. Sansom, Shigeko Yamashiro, Laura M. Machesky
Development 2013 140: 2203-2211; doi: 10.1242/dev.089789

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