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November, 2016; 143 (22)

IN THIS ISSUE

  • You have accessSubscription required
    A postnatal model for Zika virus infection
    Development 2016 143: e2201
  • You have accessSubscription required
    New network for tooth development: Sox2 bites back
    Development 2016 143: e2202

SPOTLIGHT

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    An interview with Kathryn Anderson
    Aidan Maartens
    Development 2016 143: 4095-4096; doi: 10.1242/dev.145706

    Summary: Kathryn Anderson, recipient of the Edwin G. Conklin medal, talks about swapping flies for mice, her work on primary cilia and why science needs more women in leadership positions.

MEETING REVIEW

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    Quantitative stem cell biology: the threat and the glory
    Steven M. Pollard
    Development 2016 143: 4097-4100; doi: 10.1242/dev.140541

    Summary: This meeting report highlights the major advances and emerging trends in quantitative stem cell biology as presented at the 5th annual Cambridge Stem Cell Symposium this year.

REVIEW

  • You have accessSubscription required
    The impact of transposable elements on mammalian development
    Jose L. Garcia-Perez, Thomas J. Widmann, Ian R. Adams
    Development 2016 143: 4101-4114; doi: 10.1242/dev.132639

    Summary: This Review discusses how and when transposable elements are expressed during development and how they modulate genome architecture, gene regulatory networks and protein function during embryogenesis.

STEM CELLS AND REGENERATION

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    Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal
    Zhao Sun, Wenjie Yu, Maria Sanz Navarro, Mason Sweat, Steven Eliason, Thad Sharp, Huan Liu, Kerstin Seidel, Li Zhang, Myriam Moreno, Thomas Lynch, Nathan E. Holton, Laura Rogers, Traci Neff, Michael J. Goodheart, Frederic Michon, Ophir D. Klein, Yang Chai, Adam Dupuy, John F. Engelhardt, Zhi Chen, Brad A. Amendt
    Development 2016 143: 4115-4126; doi: 10.1242/dev.138883

    Highlighted article: Conditional Sox2 ablation affects dental epithelial stem cell proliferation and differentiation and causes arrested incisor development and abnormal molar development in rodents.

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    Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage
    Qiang Shao, Stephanie Herrlinger, Si-Lu Yang, Fan Lai, Julie M. Moore, Melinda A. Brindley, Jian-Fu Chen
    Development 2016 143: 4127-4136; doi: 10.1242/dev.143768

    Highlighted article: A postnatal model for ZIKV infection reveals blood-brain barrier leakage, neuronal death, apoptosis and cell cycle arrest of NPCs, leading to microcephaly with brain damage in ZIKV-infected pups.

  • Open Access
    MicroRNA deep sequencing in two adult stem cell populations identifies miR-501 as a novel regulator of myosin heavy chain during muscle regeneration
    Amir Mizbani, Edlira Luca, Elisabeth J. Rushing, Jan Krützfeldt
    Development 2016 143: 4137-4148; doi: 10.1242/dev.136051

    Summary: MicroRNA 501 is a novel muscle-specific microRNA that is induced during muscle regeneration and regulates the transition of myosin heavy chains during early myogenesis.

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    Localization of planarian β-CATENIN-1 reveals multiple roles during anterior-posterior regeneration and organogenesis
    Miquel Sureda-Gómez, José M. Martín-Durán, Teresa Adell
    Development 2016 143: 4149-4160; doi: 10.1242/dev.135152

    Summary: Immunohistochemistry reveals an anteroposterior gradient of nuclear β-CATENIN-1 in the adult planarian, with the lowest levels in the pre-pharyngeal region and the highest levels at the tip of the tail.

  • Open Access
    A reporter model to visualize imprinting stability at the Dlk1 locus during mouse development and in pluripotent cells
    Emily Swanzey, Matthias Stadtfeld
    Development 2016 143: 4161-4166; doi: 10.1242/dev.138255

    Summary: A Dlk1 knock-in reporter mouse reports allele- and tissue-specific Dlk1 expression in developing embryos that can be used to study changes in genomic imprinting during cellular reprogramming.

RESEARCH REPORT

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    Antagonism between β-catenin and Gata.a sequentially segregates the germ layers of ascidian embryos
    Kaoru S. Imai, Clare Hudson, Izumi Oda-Ishii, Hitoyoshi Yasuo, Yutaka Satou
    Development 2016 143: 4167-4172; doi: 10.1242/dev.141481

    Summary: The antagonistic action between β-catenin and Gata.a in Ciona intestinalis is involved in segregation between ectoderm and endomesoderm at the 16-cell stage, and between endoderm and mesoderm at the 32-cell stage.

RESEARCH ARTICLES

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    A network of conserved formins, regulated by the guanine exchange factor EXC-5 and the GTPase CDC-42, modulates tubulogenesis in vivo
    Daniel D. Shaye, Iva Greenwald
    Development 2016 143: 4173-4181; doi: 10.1242/dev.141861

    Summary: An EXC-5/FGD-CDC-42 pathway regulates the two formins INFT-2/INF2 and CYK-1/mDia to control F-actin levels and modulate cell outgrowth during tubulogenesis in C. elegans.

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    The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis
    Keren Gueta, Ahuvit David, Tsadok Cohen, Yotam Menuchin-Lasowski, Hila Nobel, Ginat Narkis, LiQi Li, Paul Love, Jimmy de Melo, Seth Blackshaw, Heiner Westphal, Ruth Ashery-Padan
    Development 2016 143: 4182-4192; doi: 10.1242/dev.129734

    Summary: Ldb1 and Ldb2 have both overlapping and specific functions in mouse retinal development, specifically in maintaining the pool of retinal progenitors and for the generation of early-born photoreceptors.

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    Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells
    Courtney R. Bone, Yu-Tai Chang, Natalie E. Cain, Shaun P. Murphy, Daniel A. Starr
    Development 2016 143: 4193-4202; doi: 10.1242/dev.141192

    Summary: Nuclear migration through a constricted space of about 200 nm between muscle and cuticle in C. elegans larval P cells requires microtubule motors, actin and nuclear deformation.

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    A new mode of mitochondrial transport and polarized sorting regulated by Dynein, Milton and Miro
    Anna Melkov, Raju Baskar, Yehonatan Alcalay, Uri Abdu
    Development 2016 143: 4203-4213; doi: 10.1242/dev.138289

    Summary: Bi-directional mitochondrial transport driven by Dynein is regulated by Milton at primary anterograde sorting, whereas Miro regulates a retrograde transport switch.

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    A gene regulatory network for apical organ neurogenesis and its spatial control in sea star embryos
    Alys M. Cheatle Jarvela, Kristen A. Yankura, Veronica F. Hinman
    Development 2016 143: 4214-4223; doi: 10.1242/dev.134999

    Summary: The progression of apical organ neurogenesis in sea star larvae is controlled by the formation of nested concentric domains of gene expression along the anteroposterior axis.

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    The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM
    Dolores Irala, Antonela Bonafina, Paula Aldana Fontanet, Fernando Cruz Alsina, Gustavo Paratcha, Fernanda Ledda
    Development 2016 143: 4224-4235; doi: 10.1242/dev.140350

    Summary: Postsynaptic engagement of GDNF and GFRα1 is required for proper development of hippocampal dendritic arbors and spine maturation through NCAM signaling.

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    Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis
    Richard E. Heinz, Michael C. Rudolph, Palani Ramanathan, Nicole S. Spoelstra, Kiel T. Butterfield, Patricia G. Webb, Beatrice L. Babbs, Hongwei Gao, Shang Chen, Michael A. Gordon, Steve M. Anderson, Margaret C. Neville, Haihua Gu, Jennifer K. Richer
    Development 2016 143: 4236-4248; doi: 10.1242/dev.139642

    Summary: A decline in miR-150 is critical for lactation, as pups nursed by dams in which this decline is prevented exhibit a dramatic decrease in survival compared with littermate controls.

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    Functional antagonism of voltage-gated K+ channel α-subunits in the developing brain ventricular system
    Hongyuan Shen, Elke Bocksteins, Igor Kondrychyn, Dirk Snyders, Vladimir Korzh
    Development 2016 143: 4249-4260; doi: 10.1242/dev.140467

    Summary: Voltage-gated K+ channels establish a balance between cell proliferation and barrier properties in the neuroepithelium that lines the ventricles during development of the zebrafish brain ventricular system.

  • Open Access
    Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila
    Guangxia Miao, Shigeo Hayashi
    Development 2016 143: 4261-4271; doi: 10.1242/dev.133322

    Summary: The migratory behavior of tracheal fusion cells is controlled by the FGF-induced expression of the transcription factor Escargot, which subsequently suppresses ERK signaling.

TECHNIQUES AND RESOURCES

  • Open Access
    iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins
    Jose Arturo Gutierrez-Triana, Juan L. Mateo, David Ibberson, Soojin Ryu, Joachim Wittbrodt
    Development 2016 143: 4272-4278; doi: 10.1242/dev.139261

    Summary: Critical improvements to the DamID protocol improve specificity and sensitivity in determining genome-wide protein-DNA interactions in transient or stable transgenic animal lines.

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    Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons
    Thomas Weber, Kazuhiko Namikawa, Barbara Winter, Karina Müller-Brown, Ralf Kühn, Wolfgang Wurst, Reinhard W. Köster
    Development 2016 143: 4279-4287; doi: 10.1242/dev.122721

    Summary: Tamoxifen-induced Caspase activation in zebrafish enables fast, efficient and specific cell ablation via targeted apoptosis.

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

  • From Journal of Cell Science

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      VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis
      Dimitris Basagiannis, Sofia Zografou, Carol Murphy, Theodore Fotsis, Lucia Morbidelli, Marina Ziche, Christopher Bleck, Jason Mercer, Savvas Christoforidis
      Development 2016 143: e1.1 doi: 10.1242/dev.146456
    • You have accessSubscription required
      Localized translation regulates cell adhesion and transendothelial migration
      Jonathan Bergeman, Alexia Caillier, François Houle, Laurence M. Gagné, Marc-Étienne Huot
      Development 2016 143: e1.2 doi: 10.1242/dev.146464
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Development: 143 (22)
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    Brachyury controls Ciona notochord fate as part of a feedforward network

    Wendy M. Reeves, Kotaro Shimai, Konner M. Winkley, Michael T. Veeman
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    Enteric nervous system can regenerate in zebrafish larva via migration into the ablated area and proliferation of neural crest-derived cells

    Maria Ohno, Masataka Nikaido, Natsumi Horiuchi, Koichi Kawakami, Kohei Hatta
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    Pharyngeal pouches provide a niche microenvironment for arch artery progenitor specification

    Aihua Mao, Mingming Zhang, Linwei Li, Jie Liu, Guozhu Ning, Yu Cao, Qiang Wang
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  • Open Access

    Widespread labeling and genomic editing of the fetal central nervous system by in utero CRISRP AAV9-PHP.eB administration

    Shuntong Hu, Tao Yang, Yu Wang
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  • Open Access

    Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development

    Yuanyuan Ma, Junjun Jing, Jifan Feng, Yuan Yuan, Quan Wen, Xia Han, Jinzhi He, Shuo Chen, Thach-Vu Ho, Yang Chai
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Kathryn Virginia Anderson (1952-2020)

Developmental geneticist Kathryn Anderson passed away at home on 30 November 2020. Tamara Caspary, a former postdoc and friend, remembers Kathryn and her remarkable contribution to developmental biology.


Zooming into 2021

In a new Editorial, Editor-in-Chief James Briscoe and Executive Editor Katherine Brown reflect on the triumphs and tribulations of the last 12 months, and look towards a hopefully calmer and more predictable year.


Read & Publish participation extends worldwide

Over 60 institutions in 12 countries are now participating in our Read & Publish initiative. Here, James Briscoe explains what this means for his institution, The Francis Crick Institute. Find out more and view our full list of participating institutions.


Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.


Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Sign up to join our next session:

10 February
Time: 13:00 (GMT)
Chaired by: preLights

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