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December, 2016; 143 (23)

IN THIS ISSUE

  • You have accessSubscription required
    Syndecan 4 lets lymphatic endothelial cells go with the flow
    Development 2016 143: e2301
  • You have accessSubscription required
    Optimized inducible gene knockdown and knockout in hPSCs
    Development 2016 143: e2302
  • You have accessSubscription required
    Transposing from ligament to bone
    Development 2016 143: e2303
  • You have accessSubscription required
    Bringing in fresh blood: SOX7, RUNX1, AP-1 and TEAD4
    Development 2016 143: e2304
  • You have accessSubscription required
    CHK2 mediates DNA damage in adult stem cells
    Development 2016 143: e2305

SPOTLIGHT

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    An interview with David McClay
    Aidan Maartens
    Development 2016 143: 4289-4290; doi: 10.1242/dev.145771

    Summary: David McClay – recipient of the 2016 Society for Developmental Biology Lifetime Achievement Award – talks to us about his career, his research with sea urchins, and his thoughts on mentorship.

HYPOTHESIS

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    A common framework for EMT and collective cell migration
    Kyra Campbell, Jordi Casanova
    Development 2016 143: 4291-4300; doi: 10.1242/dev.139071

    Summary: This Hypothesis article poses that EMT and collective migration can be viewed as extreme cases of a general continuum, with cells displaying arrays of epithelial and mesenchymal features, and migratory behaviours.

REVIEW

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    Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming
    Abdenour Soufi, Stephen Dalton
    Development 2016 143: 4301-4311; doi: 10.1242/dev.142075

    Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.

STEM CELLS AND REGENERATION

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    DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
    Xing Ma, Yingying Han, Xiaoqing Song, Trieu Do, Zhihao Yang, Jianquan Ni, Ting Xie
    Development 2016 143: 4312-4323; doi: 10.1242/dev.141069

    Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary.

  • Open Access
    Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate
    Nadine Obier, Pierre Cauchy, Salam A. Assi, Jane Gilmour, Michael Lie-A-Ling, Monika Lichtinger, Maarten Hoogenkamp, Laura Noailles, Peter N. Cockerill, Georges Lacaud, Valerie Kouskoff, Constanze Bonifer
    Development 2016 143: 4324-4340; doi: 10.1242/dev.139857

    Highlighted article: AP-1 activates the expression of vascular genes in hemogenic endothelial cells and is required for de novo binding of the Hippo signaling transcription factor TEAD4.

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    Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac
    Andrew J. Lilly, Guilherme Costa, Anne Largeot, Muhammad Z. H. Fadlullah, Michael Lie-A-Ling, Georges Lacaud, Valerie Kouskoff
    Development 2016 143: 4341-4351; doi: 10.1242/dev.140970

    Highlighted article: In mouse hemogenic endothelium, SOX7 inhibits the expression of RUNX1 target genes by directly interacting with RUNX1 and inhibiting its transcriptional activity.

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    Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2
    Valerie S. Salazar, Satoshi Ohte, Luciane P. Capelo, Laura Gamer, Vicki Rosen
    Development 2016 143: 4352-4367; doi: 10.1242/dev.136879

    Summary: Osteoblast specification requires regulatory inputs from BMP2 at the Runx2/Osx1 transition by a mechanism that is not compensated for by canonical Wnt signaling and involves Grhl3.

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    Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality
    Ludovic Zimmerlin, Tea Soon Park, Jeffrey S. Huo, Karan Verma, Sarshan R. Pather, C. Conover Talbot, Jr., Jasmin Agarwal, Diana Steppan, Yang W. Zhang, Michael Considine, Hong Guo, Xiufeng Zhong, Christian Gutierrez, Leslie Cope, M. Valeria Canto-Soler, Alan D. Friedman, Stephen B. Baylin, Elias T. Zambidis
    Development 2016 143: 4368-4380; doi: 10.1242/dev.138982

    Summary: A broad repertoire of conventional human ESCs and transgene-independent iPSC lines can be reverted to stable naive states using WNT, MEK/ERK and tankyrase inhibition.

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    Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs
    Will J. McLean, Dalton T. McLean, Ruth Anne Eatock, Albert S. B. Edge
    Development 2016 143: 4381-4393; doi: 10.1242/dev.139840

    Summary: Progenitor cells isolated from different regions of the inner ear show distinct capacities for differentiation, acquiring phenotypic properties of their respective compartments of origin.

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    Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo
    Bradley J. Goldstein, Garrett M. Goss, Rhea Choi, Dieter Saur, Barbara Seidler, Joshua M. Hare, Nirupa Chaudhari
    Development 2016 143: 4394-4404; doi: 10.1242/dev.142653

    Summary: Adult c-KIT+ olfactory basal stem cells may be propagated as expansion-competent BMI1+ progenitors in culture and provide insight into olfactory homeostasis.

  • Open Access
    Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs
    Alessandro Bertero, Matthias Pawlowski, Daniel Ortmann, Kirsten Snijders, Loukia Yiangou, Miguel Cardoso de Brito, Stephanie Brown, William G. Bernard, James D. Cooper, Elisa Giacomelli, Laure Gambardella, Nicholas R. F. Hannan, Dharini Iyer, Fotios Sampaziotis, Felipe Serrano, Mariëlle C. F. Zonneveld, Sanjay Sinha, Mark Kotter, Ludovic Vallier
    Development 2016 143: 4405-4418; doi: 10.1242/dev.138081

    Highlighted article: Novel optimized inducible knockdown and knockout platforms are developed and used to assess gene function in human pluripotent stem cells and their differentiated progeny.

RESEARCH REPORTS

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    Cytokinin response factors integrate auxin and cytokinin pathways for female reproductive organ development
    Mara Cucinotta, Silvia Manrique, Andrea Guazzotti, Nadia E. Quadrelli, Marta A. Mendes, Eva Benkova, Lucia Colombo
    Development 2016 143: 4419-4424; doi: 10.1242/dev.143545

    Summary: CRF2, CRF3 and CRF6 are required to regulate PIN1 expression in the inflorescence and this regulation is necessary for correct pistil elongation and ovule number.

  • You have accessSubscription required
    Ovary-derived precursor gibberellin A9 is essential for female flower development in cucumber
    Maria João Pimenta Lange, Theo Lange
    Development 2016 143: 4425-4429; doi: 10.1242/dev.135947

    Summary: During cucumber female flower development, ovaries produce the gibberellin precursor GA9, which is translocated to the sepal/petals and converted into bioactive GA4.

RESEARCH ARTICLES

  • You have accessSubscription required
    Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca
    James T. Nichols, Bernardo Blanco-Sánchez, Elliott P. Brooks, Raghuveer Parthasarathy, John Dowd, Arul Subramanian, Gregory Nachtrab, Kenneth D. Poss, Thomas F. Schilling, Charles B. Kimmel
    Development 2016 143: 4430-4440; doi: 10.1242/dev.141036

    Highlighted article: Phenotypic variation in zebrafish mef2ca mutants is due to cells switching fate, from ligament to bone, possibly as a result of variable transposon epigenetic silencing.

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    Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development
    Yingdi Wang, Nicolas Baeyens, Federico Corti, Keiichiro Tanaka, Jennifer S. Fang, Jiasheng Zhang, Yu Jin, Brian Coon, Karen K. Hirschi, Martin A. Schwartz, Michael Simons
    Development 2016 143: 4441-4451; doi: 10.1242/dev.140129

    Highlighted article: Perturbation of syndecan 4 in mouse embryos reveals a new mechanism of fluid shear stress-mediated signaling involving syndecan 4-dependent upregulation of the PCP protein Vangl2.

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    Demethylation of ERECTA receptor genes by IBM1 histone demethylase affects stomatal development
    Yuhua Wang, Xueyi Xue, Jian-Kang Zhu, Juan Dong
    Development 2016 143: 4452-4461; doi: 10.1242/dev.129932

    Summary: The histone demethylase IBM1 regulates Arabidopsis stomatal development by suppressing DNA methylation on the gene body region of ERECTA receptors.

  • You have accessSubscription required
    Six3 dosage mediates the pathogenesis of holoprosencephaly
    Xin Geng, Sandra Acosta, Oleg Lagutin, Hyea Jin Gil, Guillermo Oliver
    Development 2016 143: 4462-4473; doi: 10.1242/dev.132142

    Summary: Analysis of a hypomorphic Six3 allele reveals that variability in Six3 dosage is sufficient to generate mice exhibiting a spectrum of holoprosencephaly forms in a non-strain-specific manner.

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    Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues
    Piero Sanfilippo, Peter Smibert, Hong Duan, Eric C. Lai
    Development 2016 143: 4474-4485; doi: 10.1242/dev.141978

    Summary: Elav – the canonical Drosophila marker for post-mitotic neurons – has a previously unrecognized component of ubiquitous expression that is suppressed by the microRNA pathway, including by miR-279/996.

  • Open Access
    Widespread failure to complete meiosis does not impair fecundity in parthenogenetic whiptail lizards
    Aracely A. Newton, Robert R. Schnittker, Zulin Yu, Sarah S. Munday, Diana P. Baumann, William B. Neaves, Peter Baumann
    Development 2016 143: 4486-4494; doi: 10.1242/dev.141283

    Summary: The fecundity of unisexual whiptail lizards is similar to bisexual relatives despite pseudo-tetraploid oocytes being exceedingly rare and diploid oocytes failing to proceed past the pairing stage of meiosis.

  • You have accessSubscription required
    Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe
    Maarja Haugas, Laura Tikker, Kaia Achim, Marjo Salminen, Juha Partanen
    Development 2016 143: 4495-4508; doi: 10.1242/dev.136614

    Summary: Dorsal raphe neurons in mice exhibit functionally significant heterogeneity that is established early during their differentiation via the actions of Gata2 and Gata3.

  • You have accessSubscription required
    Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway
    Gewei Lian, Markus Dettenhofer, Jie Lu, Michael Downing, Anjen Chenn, Timothy Wong, Volney Sheen
    Development 2016 143: 4509-4520; doi: 10.1242/dev.139295

    Summary: Loss of filamin and formin causes multiple developmental defects, highlighting roles for these two proteins in Wnt signaling, Lrp6 endocytosis, Gsk3 activation and target gene expression.

  • You have accessSubscription required
    Sensory evolution in blind cavefish is driven by early embryonic events during gastrulation and neurulation
    Hélène Hinaux, Lucie Devos, Maryline Blin, Yannick Elipot, Jonathan Bibliowicz, Alexandre Alié, Sylvie Rétaux
    Development 2016 143: 4521-4532; doi: 10.1242/dev.141291

    Summary: The analysis of Shh signaling, Fgf8 signaling and Bmp4 expression dynamics in cavefish embryos reveals subtle modifications in these pathways that lead to a change in lens versus olfactory fate.

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    Identification and in silico modeling of enhancers reveals new features of the cardiac differentiation network
    Denis Seyres, Yad Ghavi-Helm, Guillaume Junion, Ouarda Taghli-Lamallem, Céline Guichard, Laurence Röder, Charles Girardot, Eileen E. M. Furlong, Laurent Perrin
    Development 2016 143: 4533-4542; doi: 10.1242/dev.140822

    Summary: The analysis of chromatin landscapes, complemented by a machine learning approach, identifies active promoters and enhancers in Drosophila cardiomyocytes, including many new enhancers and their associated transcription factor motifs.

  • You have accessSubscription required
    Drosophila Crumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis
    Linda Nemetschke, Elisabeth Knust
    Development 2016 143: 4543-4553; doi: 10.1242/dev.141762

    Summary: In developing Drosophila wings, the apical determinant Crumbs stabilises the Notch receptor on apical membranes via direct interaction between their extracellular domains.

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

  • From Journal of Cell Science

    • You have accessSubscription required
      Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1
      Aude Espigat-Georger, Vyacheslav Dyachuk, Cécile Chemin, Laurent Emorine, Andreas Merdes
      Development 2016 143: e1.1 doi: 10.1242/dev.146878
    • You have accessSubscription required
      A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization
      Rajalakshmi Veeranan-Karmegam, Devi Prasad Boggupalli, Guojun Liu, Graydon B. Gonsalvez
      Development 2016 143: e1.2 doi: 10.1242/dev.146886
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    Robustness and timing of cellular differentiation through population-based symmetry breaking

    Angel Stanoev, Christian Schröter, Aneta Koseska
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    Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling

    Mengyun Wang, Yue Du, Song Gao, Zheng Wang, Pengxiang Qu, Yang Gao, Jingyi Wang, Zhengqi Liu, Jingcheng Zhang, Yong Zhang, Suzhu Qing, Yongsheng Wang
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    HoxB genes regulate neuronal delamination in the trunk neural tube by controlling the expression of Lzts1

    Axelle Wilmerding, Lucrezia Rinaldi, Nathalie Caruso, Laure Lo Re, Emilie Bonzom, Andrew J. Saurin, Yacine Graba, Marie-Claire Delfini
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    Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor

    Keishi Otsu, Hiroko Ida-Yonemochi, Shojiro Ikezaki, Masatsugu Ema, Jiro Hitomi, Hayato Ohshima, Hidemitsu Harada
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    Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes

    Daniel J. Barbosa, Vanessa Teixeira, Joana Duro, Ana X. Carvalho, Reto Gassmann
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