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RESEARCH ARTICLE
A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice
Zakia Abdelhamed, Shawn M. Vuong, Lauren Hill, Crystal Shula, Andrew Timms, David Beier, Kenneth Campbell, Francesco T. Mangano, Rolf W. Stottmann, June Goto
Development 2018 145: dev154500 doi: 10.1242/dev.154500 Published 9 January 2018
Zakia Abdelhamed
1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
2Department of Anatomy and Embryology, Faculty of Medicine (Girls’ Section), Al-Azhar University, Cairo 11651, Egypt
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Shawn M. Vuong
1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
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Lauren Hill
1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
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Crystal Shula
1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
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Andrew Timms
3Center for Developmental Biology and Regenerative Medicine, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA
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David Beier
3Center for Developmental Biology and Regenerative Medicine, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA
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Kenneth Campbell
1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
4Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242 USA
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Francesco T. Mangano
1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
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Rolf W. Stottmann
4Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242 USA
5Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242 USA
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  • ORCID record for Rolf W. Stottmann
  • For correspondence: Rolf.Stottmann@cchmc.org June.Goto@cchmc.org
June Goto
1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
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  • ORCID record for June Goto
  • For correspondence: Rolf.Stottmann@cchmc.org June.Goto@cchmc.org
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Article Information

vol. 145 no. 1, dev154500

DOI 
https://doi.org/10.1242/dev.154500
PubMed 
29317443

Published By 
The Company of Biologists Ltd
Print ISSN 
0950-1991
Online ISSN 
1477-9129
History 
  • Received May 9, 2017
  • Accepted November 16, 2017
  • Published online January 9, 2018.
Copyright & Usage 
© 2018. Published by The Company of Biologists Ltd


Author Information

  1. Zakia Abdelhamed1,2,
  2. Shawn M. Vuong1,
  3. Lauren Hill1,
  4. Crystal Shula1,
  5. Andrew Timms3,
  6. David Beier3,
  7. Kenneth Campbell1,4,
  8. Francesco T. Mangano1,
  9. Rolf W. Stottmann4,5,* and
  10. June Goto1,*
  1. 1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242, USA
  2. 2Department of Anatomy and Embryology, Faculty of Medicine (Girls’ Section), Al-Azhar University, Cairo 11651, Egypt
  3. 3Center for Developmental Biology and Regenerative Medicine, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA
  4. 4Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242 USA
  5. 5Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45242 USA
  1. ↵*Authors for correspondence (Rolf.Stottmann{at}cchmc.org; June.Goto{at}cchmc.org)
View Abstract

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Jan 20181136226129
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Total 2021913549
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Keywords

  • Cilia
  • Hydrocephalus
  • Ependymal cells
  • Cerebrospinal fluid
  • Brain development

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RESEARCH ARTICLE
A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice
Zakia Abdelhamed, Shawn M. Vuong, Lauren Hill, Crystal Shula, Andrew Timms, David Beier, Kenneth Campbell, Francesco T. Mangano, Rolf W. Stottmann, June Goto
Development 2018 145: dev154500 doi: 10.1242/dev.154500 Published 9 January 2018
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RESEARCH ARTICLE
A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice
Zakia Abdelhamed, Shawn M. Vuong, Lauren Hill, Crystal Shula, Andrew Timms, David Beier, Kenneth Campbell, Francesco T. Mangano, Rolf W. Stottmann, June Goto
Development 2018 145: dev154500 doi: 10.1242/dev.154500 Published 9 January 2018

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