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February, 2018; 145 (4)

RESEARCH HIGHLIGHTS

  • You have accessSubscription required
    It's about time: a mESC-derived model of the segmentation clock
    Development 2018 145: e0401
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    Resident microbes in development: a gut feeling for Notch
    Development 2018 145: e0402
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    Podoplanin and Wnt/β-cat signaling: new partners in mammary development and tumorigenesis
    Development 2018 145: e0403

EDITORIAL

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    Introducing preLights: preprint highlights, selected by the biological community
    Katherine Brown, Olivier Pourquié
    Development 2018 145: dev164186 doi: 10.1242/dev.164186 Published 22 February 2018

SPOTLIGHT

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    An interview with Ykä Helariutta
    Aidan Maartens
    Development 2018 145: dev162339 doi: 10.1242/dev.162339 Published 27 February 2018

DEVELOPMENT AT A GLANCE

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    Cytokinin signaling in plant development
    Joseph J. Kieber, G. Eric Schaller
    Development 2018 145: dev149344 doi: 10.1242/dev.149344 Published 27 February 2018

REVIEW

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    Autophagy in stem cells: repair, remodelling and metabolic reprogramming
    Patricia Boya, Patrice Codogno, Natalia Rodriguez-Muela
    Development 2018 145: dev146506 doi: 10.1242/dev.146506 Published 26 February 2018

    Summary: This Review summarizes the role of autophagy in embryonic, adult and cancer stem cells and cellular reprogramming, and highlights the consequences of autophagy dysregulation on tissue development and homeostasis.

HUMAN DEVELOPMENT

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    TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency
    Robert A. Sierra, Nathan P. Hoverter, Ricardo N. Ramirez, Linh M. Vuong, Ali Mortazavi, Bradley J. Merrill, Marian L. Waterman, Peter J. Donovan
    Development 2018 145: dev161075 doi: 10.1242/dev.161075 Published 23 February 2018

    Summary: TCF7L1 represses PS gene expression to maintain the primed, pluripotent state, with relief of this repression by BMP4 leading to upregulation of PS-promoting genes (including NODAL, WNT3 and BMP4) to drive hESC differentiation.

STEM CELLS AND REGENERATION

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    Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling
    Laura Bresson, Marisa M. Faraldo, Amandine Di-Cicco, Miguel Quintanilla, Marina A. Glukhova, Marie-Ange Deugnier
    Development 2018 145: dev160382 doi: 10.1242/dev.160382 Published 21 February 2018

    Highlighted Article: This study reveals a role for the transmembrane glycoprotein podoplanin in mammary stem cell function and tumorigenesis through the positive regulation of Wnt/β-catenin signaling.

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    H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming
    Xin Liu, Yizhi Wang, Yuanpeng Gao, Jianmin Su, Jingcheng Zhang, Xupeng Xing, Chuan Zhou, Kezhen Yao, Quanli An, Yong Zhang
    Development 2018 145: dev158261 doi: 10.1242/dev.158261 Published 16 February 2018

    Summary: RNA-dependent KDM4E chromatin localization is essential for active H3K9 demethylation during bovine embryonic genome activation, an observation that could improve outcomes in cloned cattle production.

  • Open Access
    ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock
    Marina Matsumiya, Takehito Tomita, Kumiko Yoshioka-Kobayashi, Akihiro Isomura, Ryoichiro Kageyama
    Development 2018 145: dev156836 doi: 10.1242/dev.156836 Published 14 February 2018

    Highlighted Article: Embryonic stem cell-derived presomitic mesoderm-like tissues exhibit synchronized Hes7 oscillations, anterior-posterior-like axis formation and segment formation, and are suitable for chemical-library screening for detailed analysis of the segmentation clock.

RESEARCH REPORT

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    Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling
    Joshua V. Troll, M. Kristina Hamilton, Melissa L. Abel, Julia Ganz, Jennifer M. Bates, W. Zac Stephens, Ellie Melancon, Michiel van der Vaart, Annemarie H. Meijer, Martin Distel, Judith S. Eisen, Karen Guillemin
    Development 2018 145: dev155317 doi: 10.1242/dev.155317 Published 23 February 2018

    Highlighted Article: Investigations in gnotobiotic zebrafish reveal that resident intestinal microbes determine intestinal secretory cell fate by modulating host Notch signaling, a highly conserved pathway involved in myriad host cell fate decisions.

RESEARCH ARTICLES

  • Open Access
    Connexin 30 controls astroglial polarization during postnatal brain development
    Grégory Ghézali, Charles-Félix Calvo, Laure-Elise Pillet, Flora Llense, Pascal Ezan, Ulrike Pannasch, Alexis-Pierre Bemelmans, Sandrine Etienne Manneville, Nathalie Rouach
    Development 2018 145: dev155275 doi: 10.1242/dev.155275 Published 23 February 2018

    Summary: Connexin 30 sets the orientation of astroglial motile protrusions during polarized migration in vitro and contributes in vivo to the establishment of hippocampal astrocyte polarity during postnatal maturation.

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    Forced lipophagy reveals that lipid droplets are required for early embryonic development in mouse
    Takayuki Tatsumi, Kaori Takayama, Shunsuke Ishii, Atsushi Yamamoto, Taichi Hara, Naojiro Minami, Naoyuki Miyasaka, Toshiro Kubota, Akira Matsuura, Eisuke Itakura, Satoshi Tsukamoto
    Development 2018 145: dev161893 doi: 10.1242/dev.161893 Published 23 February 2018

    Summary: A forced lipophagy system, established by expressing an autophagy adaptor on the surface of lipid droplets, demonstrates that depletion of lipid droplets in fertilized mouse embryos causes developmental retardation.

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    Lsd1 interacts with cMyb to demethylate repressive histone marks and maintain inner ear progenitor identity
    Mohi Ahmed, Andrea Streit
    Development 2018 145: dev160325 doi: 10.1242/dev.160325 Published 21 February 2018

    Summary: In chick inner ear development, cMyb is identified as a novel Lsd1-interacting partner that recruits Lsd1 to promoter regions of actively transcribed genes to control H3K9 demethylation.

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    Mesenchymal Wnt/β-catenin signaling limits tooth number
    Elina Järvinen, Junko Shimomura-Kuroki, Anamaria Balic, Maria Jussila, Irma Thesleff
    Development 2018 145: dev158048 doi: 10.1242/dev.158048 Published 21 February 2018

    Summary: Using mouse models to investigate serial tooth formation reveals that contrasting changes in tooth number associated with human mutations in AXIN2 and RUNX2 result from modulation of Wnt/β-catenin signaling in dental mesenchyme.

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    β-Catenin signaling is essential for mammalian larynx recanalization and the establishment of vocal fold progenitor cells
    Vlasta Lungova, Jamie M. Verheyden, Xin Sun, Susan L. Thibeault
    Development 2018 145: dev157677 doi: 10.1242/dev.157677 Published 16 February 2018

    Summary: The first demonstration that β-catenin signaling contributes to vocal fold morphogenesis by regulating proliferation and epithelial progenitor establishment, shedding light on the etiology of poorly understood congenital laryngeal malformations.

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    The ELMO-MBC complex and RhoGAP19D couple Rho family GTPases during mesenchymal-to-epithelial-like transitions
    Christopher P. Toret, Pruthvi C. Shivakumar, Pierre-François Lenne, Andre Le Bivic
    Development 2018 145: dev157495 doi: 10.1242/dev.157495 Published 14 February 2018

    Summary: Rac and Rho activities during dorsal closure are coordinated by the atypical Rac GEF, the ELMO-MBC complex and the Rho GAP RhoGAP19D during in vivo Drosophila mesenchymal-to-epithelial-like transitions.

TECHNIQUES AND RESOURCES

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    Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo
    Ruth M. Williams, Upeka Senanayake, Mara Artibani, Gunes Taylor, Daniel Wells, Ahmed Ashour Ahmed, Tatjana Sauka-Spengler
    Development 2018 145: dev160333 doi: 10.1242/dev.160333 Published 23 February 2018

    Summary: The use of an optimised toolkit for efficient genome and epigenome engineering using CRISPR in chicken embryos is demonstrated, focussing on probing gene regulatory interactions during neural crest development.

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    Validating upstream regulators of Yorkie activity in Hippo signaling through scalloped-based genetic epistasis
    Jianzhong Yu, Duojia Pan
    Development 2018 145: dev157545 doi: 10.1242/dev.157545 Published 21 February 2018

    Summary: Analysis of double-mutant clones of sd and putative Yki regulators provides a simple and efficient strategy to validate upstream regulators of Yki activity in Hippo signaling.

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    A genetically encoded fluorescent probe for imaging of oxygenation gradients in living Drosophila
    Peter V. Lidsky, Konstantin A. Lukyanov, Tvisha Misra, Björn Handke, Alexander S. Mishin, Christian F. Lehner
    Development 2018 145: dev156257 doi: 10.1242/dev.156257 Published 14 February 2018

    Summary: DsRed FT forms the basis of a simple and robust method for direct visualization of oxygenation exposure that is applicable to whole animals with single-cell precision.

CORRECTION

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    Correction: CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation (doi:10.1242/dev.158584)
    HaiYang Wang, Min Ho Choe, In-Won Lee, Suk Namgoong, Jae-Sung Kim, Nam-Hyung Kim, Jeong Su Oh
    Development 2018 145: dev164483 doi: 10.1242/dev.164483 Published 21 February 2018
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Development: 145 (4)
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  • RESEARCH HIGHLIGHTS
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  • DEVELOPMENT AT A GLANCE
  • REVIEW
  • HUMAN DEVELOPMENT
  • STEM CELLS AND REGENERATION
  • RESEARCH REPORT
  • RESEARCH ARTICLES
  • TECHNIQUES AND RESOURCES
  • CORRECTION

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    Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes

    Daniel J. Barbosa, Vanessa Teixeira, Joana Duro, Ana X. Carvalho, Reto Gassmann
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    CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains

    Toshiya Kimura, Hiroko Saito, Miwa Kawasaki, Masatoshi Takeichi
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    Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

    Thomas J. Cahill, Xin Sun, Christophe Ravaud, Cristina Villa del Campo, Konstantinos Klaourakis, Irina-Elena Lupu, Allegra M. Lord, Cathy Browne, Sten Eirik W. Jacobsen, David R. Greaves, David G. Jackson, Sally A. Cowley, William James, Robin P. Choudhury, Joaquim Miguel Vieira, Paul R. Riley
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    C. elegans establishes germline versus soma by balancing inherited histone methylation

    Brandon S. Carpenter, Teresa W. Lee, Caroline F. Plott, Juan D. Rodriguez, Jovan S. Brockett, Dexter A. Myrick, David J. Katz
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    Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton

    Joanna Smeeton, Natasha Natarajan, Arati Naveen Kumar, Tetsuto Miyashita, Pranidhi Baddam, Peter Fabian, Daniel Graf, J. Gage Crump
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Kathryn Virginia Anderson (1952-2020)

Developmental geneticist Kathryn Anderson passed away at home on 30 November 2020. Tamara Caspary, a former postdoc and friend, remembers Kathryn and her remarkable contribution to developmental biology.


Zooming into 2021

In a new Editorial, Editor-in-Chief James Briscoe and Executive Editor Katherine Brown reflect on the triumphs and tribulations of the last 12 months, and look towards a hopefully calmer and more predictable year.


Read & Publish participation extends worldwide

Over 60 institutions in 12 countries are now participating in our Read & Publish initiative. Here, James Briscoe explains what this means for his institution, The Francis Crick Institute. Find out more and view our full list of participating institutions.


Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.


Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Sign up to join our next session:

10 February
Time: 13:00 (GMT)
Chaired by: preLights

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