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July, 2019; 146 (13)

RESEARCH HIGHLIGHTS

  • You have accessSubscription required
    Teasing asymmetric cell division and differentiation apart
    Development 2019 146: e1301
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    Initiation and maintenance: transcriptional autoregulation in C. elegans
    Development 2019 146: e1302
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    RGCing the light with help from mTOR
    Development 2019 146: e1303

INTERVIEW

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    The people behind the papers – Eduardo Leyva-Díaz and Oliver Hobert
    Development 2019 146: dev180869 doi: 10.1242/dev.180869 Published 21 June 2019

DEVELOPMENT AT A GLANCE

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    Retinoic acid signaling pathways
    Norbert B. Ghyselinck, Gregg Duester
    Development 2019 146: dev167502 doi: 10.1242/dev.167502 Published 4 July 2019

    Summary: This Development at a Glance article highlights how retinoic acid and its nuclear receptors regulate organ development, which may guide efforts for its use as a therapeutic agent to improve human health.

MEETING REVIEW

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    A SY-Stematic approach towards understanding stem cell biology
    Gregor-Alexander Pilz, Marlen Knobloch
    Development 2019 146: dev177220 doi: 10.1242/dev.177220 Published 21 June 2019

    Summary: This Meeting Review reports on the main results presented 2nd SY-Stem Symposium held in March 2019.

REVIEW

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    Cell competition: the winners and losers of fitness selection
    Sarah Bowling, Katerina Lawlor, Tristan A. Rodríguez
    Development 2019 146: dev167486 doi: 10.1242/dev.167486 Published 5 July 2019

    Summary: This Review summarises key discoveries in the field of cell competition and outlines exciting future directions for this area of research.

HUMAN DEVELOPMENT

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    Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway
    Pooja Teotia, Matthew J. Van Hook, Dietmar Fischer, Iqbal Ahmad
    Development 2019 146: dev178012 doi: 10.1242/dev.178012 Published 4 July 2019

    Highlighted Article: Recruitment of the developmentally relevant mTOR pathway can facilitate regeneration of injured axons of human retinal neurons, which die in glaucoma leading to irreversible vision loss.

STEM CELLS AND REGENERATION

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    Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties
    Robert A. Bradley, Jack Shireman, Caya McFalls, Jeea Choi, Scott G. Canfield, Yi Dong, Katie Liu, Brianne Lisota, Jeffery R. Jones, Andrew Petersen, Anita Bhattacharyya, Sean P. Palecek, Eric V. Shusta, Christina Kendziorski, Su-Chun Zhang
    Development 2019 146: dev170910 doi: 10.1242/dev.170910 Published 8 July 2019

    Summary: Astrocytes generated from hPSC-derived regional neural progenitors maintain their identity throughout their differentiation and exhibit differential gene expression and functions, suggesting developmental origins of astrocyte functional diversity.

  • Open Access
    Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart
    Vanessa Lowe, Laura Wisniewski, Jacob Sayers, Ian Evans, Paul Frankel, Nadia Mercader-Huber, Ian C. Zachary, Caroline Pellet-Many
    Development 2019 146: dev174482 doi: 10.1242/dev.174482 Published 2 July 2019

    Summary: nrp1a is required for zebrafish heart regeneration in response to cryoinjury by inducing wt1b to promote the revascularization, and the activation and migration of the epicardium.

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    The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
    Ying Mao, Renjun Tu, Yan Huang, Decai Mao, Zhihao Yang, Pik Ki Lau, Jinhui Wang, Jianquan Ni, Yusong Guo, Ting Xie
    Development 2019 146: dev174615 doi: 10.1242/dev.174615 Published 28 June 2019

    Summary: The exocyst directly controls EGFR membrane trafficking, recycling and activation in Drosophila and human cells, and is required in the niche to promote germline stem cell differentiation by regulating EGFR signaling.

RESEARCH REPORTS

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    Organization of motor pools depends on the combined function of N-cadherin and type II cadherins
    Carola Dewitz, Xin Duan, Niccolò Zampieri
    Development 2019 146: dev180422 doi: 10.1242/dev.180422 Published 10 July 2019

    Summary: In mouse, type II cadherins control the organization of motor neurons into pools by functional interaction with N-cadherin rather than via the implementation of an adhesive code.

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    Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity
    Eduardo Leyva-Díaz, Oliver Hobert
    Development 2019 146: dev177378 doi: 10.1242/dev.177378 Published 21 June 2019

    Highlighted Article: Mutation of an autoregulatory motif of che-1, a cell identity-specifying transcription factor, shows that autoregulation is required for both acquisition and maintenance of cellular identity in C. elegans.

RESEARCH ARTICLES

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    PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis
    Xiukun Wang, Jun-Yan Kang, Leixin Wei, Xiaogan Yang, Hongduo Sun, Suming Yang, Lei Lu, Meng Yan, Meizhu Bai, Yanyan Chen, Juanjuan Long, Na Li, Dangsheng Li, Jing Huang, Ming Lei, Zhen Shao, Wen Yuan, Erwei Zuo, Kehuan Lu, Mo-Fang Liu, Jinsong Li
    Development 2019 146: dev175547 doi: 10.1242/dev.175547 Published 10 July 2019

    Summary: PHF7 functions as both an epigenetic reader that recognizes H3K4me3/2 and an epigenetic writer that can mediate H2A ubiquitylation prior to histone-to-protamine exchange in mouse spermiogenesis.

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    Type-B response regulators of rice play key roles in growth, development and cytokinin signaling
    Jennifer M. Worthen, Maria V. Yamburenko, Jeewoo Lim, Zachary L. Nimchuk, Joseph J. Kieber, G. Eric Schaller
    Development 2019 146: dev174870 doi: 10.1242/dev.174870 Published 10 July 2019

    Summary: Developmental roles are uncovered in rice for a family of transcription factors that mediate signaling using the hormone cytokinin, including roles in inflorescence branching, flower development and fertilization.

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    Tfap2a is a novel gatekeeper of nephron differentiation during kidney development
    Brooke E. Chambers, Gary F. Gerlach, Eleanor G. Clark, Karen H. Chen, Anna E. Levesque, Ignaty Leshchiner, Wolfram Goessling, Rebecca A. Wingert
    Development 2019 146: dev172387 doi: 10.1242/dev.172387 Published 10 July 2019

    Summary: tfap2a functions in distal nephron development to control the progression of cells to a fully differentiated state. This fundamentally deepens our knowledge about the genetic control of kidney development.

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    Drosophila Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation
    Neena Dhiman, Kumari Shweta, Shweta Tendulkar, Girish Deshpande, Girish S. Ratnaparkhi, Anuradha Ratnaparkhi
    Development 2019 146: dev166504 doi: 10.1242/dev.166504 Published 10 July 2019

    Summary: Mon1 activity in a small subset of 137 neurons regulates ovary maturation, over a distance, by regulating activity of insulin-like peptides.

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    PIP degron-stabilized Dacapo/p21Cip1 and mutations in ago act in an anti- versus pro-proliferative manner, yet both trigger an increase in Cyclin E levels
    Caroline Bivik Stadler, Badrul Arefin, Helen Ekman, Stefan Thor
    Development 2019 146: dev175927 doi: 10.1242/dev.175927 Published 9 July 2019

    Summary: Mutating the PIP degron stabilizes Dacapo/p21Cip1, making them strongly anti-proliferative. Yet stabilized Dacapo/p21Cip1 trigger a major increase in Cyclin E levels.

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    HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis
    Meng Xia, Wen Luo, Hengwei Jin, Zhongzhou Yang
    Development 2019 146: dev177477 doi: 10.1242/dev.177477 Published 4 July 2019

    Summary: Using aSHF-specific Hand2-deletion mice, a new function is revealed for HAND2 in mediating OFT epithelial maintenance and integrity in OFT morphogenesis during early heart development.

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    The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2
    Xue Han, Jiejie Zhang, Yaxi Liu, Xiaoying Fan, Shanshan Ai, Yingjie Luo, Xin Li, Hengwei Jin, Sai Luo, Hui Zheng, Yanzhu Yue, Zai Chang, Zhongzhou Yang, Fuchou Tang, Aibin He, Xiaohua Shen
    Development 2019 146: dev176198 doi: 10.1242/dev.176198 Published 4 July 2019

    Summary: The lncRNA Hand2os1 locus critically controls the precise expression of its neighboring gene Hand2, thereby balancing cardiac lineages and expression programs that are essential for heart development and function.

  • Open Access
    Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells
    Laura Andrés-Delgado, Alexander Ernst, María Galardi-Castilla, David Bazaga, Marina Peralta, Juliane Münch, Juan M. González-Rosa, Inês Marques, Federico Tessadori, José Luis de la Pompa, Julien Vermot, Nadia Mercader
    Development 2019 146: dev174961 doi: 10.1242/dev.174961 Published 4 July 2019

    Summary: Proepicardial cells emerge from the pericardial mesothelium through apical extrusion, a process that depends on BMP signaling and actomyosin rearrangements.

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    Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions in vivo
    Daniel B. Lybrand, Misha Naiman, Jessie May Laumann, Mitzi Boardman, Samuel Petshow, Kevin Hansen, Gregory Scott, Marcel Wehrli
    Development 2019 146: dev164145 doi: 10.1242/dev.164145 Published 2 July 2019

    Summary: Distinct conformations for active and inactivated destruction complex, the central regulator in the Wnt/β-catenin pathway, are identified in vivo using bimolecular fluorescence complementation.

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    Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis
    John E. La Marca, Sarah T. Diepstraten, Amy L. Hodge, Hongyan Wang, Adam H. Hart, Helena E. Richardson, W. Gregory Somers
    Development 2019 146: dev174292 doi: 10.1242/dev.174292 Published 28 June 2019

    Summary: A novel role for Strip and Cka in JNK signalling is revealed in the Drosophila testis, using the jam mutant.

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    Evidence of a developmental origin for β-cell heterogeneity using a dual lineage-tracing technology
    Congde Chen, Chiyo Shiota, Guy Agostinelli, Daniel Ridley, Yinan Jiang, Jie Ma, Krishna Prasadan, Xiangwei Xiao, George K. Gittes
    Development 2019 146: dev164913 doi: 10.1242/dev.164913 Published 27 June 2019

    Summary: Using a novel dual lineage-tracing technology (Dre/RoxP and Cre/LoxP), differential activation of Ptf1a in the developing pancreas is revealed to potentially correlate with β-cell heterogeneity.

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    yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets
    Javier Vázquez-Marín, José Arturo Gutiérrez-Triana, María Almuedo-Castillo, Lorena Buono, José Luis Gómez-Skarmeta, Juan Luis Mateo, Joachim Wittbrodt, Juan Ramón Martínez-Morales
    Development 2019 146: dev173286 doi: 10.1242/dev.173286 Published 21 June 2019

    Summary: Using a combination of DamID-seq and CRISPR-Cas9, the evolutionary origin, chromatin-binding properties and biological function of Yap1b, a novel Yap family member with an atypical activation domain, are investigated.

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    Specification of basal region identity after asymmetric zygotic division requires mitogen-activated protein kinase 6 in rice
    Kiyoe Ishimoto, Shino Sohonahra, Mitsuko Kishi-Kaboshi, Jun-ichi Itoh, Ken-ichiro Hibara, Yutaka Sato, Tsuneaki Watanabe, Kiyomi Abe, Akio Miyao, Misuzu Nosaka-Takahashi, Toshiya Suzuki, Nhung Kim Ta, Sae Shimizu-Sato, Takamasa Suzuki, Atsushi Toyoda, Hirokazu Takahashi, Mikio Nakazono, Yasuo Nagato, Hirohiko Hirochika, Yutaka Sato
    Development 2019 146: dev176305 doi: 10.1242/dev.176305 Published 21 June 2019

    Highlighted Article: Studies in gle4/osmpk6 rice mutants raise the possibility that the asymmetric zygotic division and cellular differentiation that lead to apical-basal polarity can be separately regulated.

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    SOX2 is required for inner ear growth and cochlear nonsensory formation before sensory development
    Aleta R. Steevens, Jenna C. Glatzer, Courtney C. Kellogg, Walter C. Low, Peter A. Santi, Amy E. Kiernan
    Development 2019 146: dev170522 doi: 10.1242/dev.170522 Published 21 June 2019

    Summary: The transcription factor SOX2 has a novel early role in promoting progenitor proliferation and in the growth and morphogenesis of the otocyst before its sensory-specific function during inner ear development.

CORRECTIONS

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    Correction: Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk (doi:10.1242/dev.178673)
    Alexander N. Combes, Belinda Phipson, Kynan T. Lawlor, Aude Dorison, Ralph Patrick, Luke Zappia, Richard P. Harvey, Alicia Oshlack, Melissa H. Little
    Development 2019 146: dev182162 doi: 10.1242/dev.182162 Published 11 July 2019
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    Correction: Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions (doi: 10.1242/dev.174177)
    Stefania Dell'Orso, Aster H. Juan, Kyung-Dae Ko, Faiza Naz, Jelena Perovanovic, Gustavo Gutierrez-Cruz, Xuesong Feng, Vittorio Sartorelli
    Development 2019 146: dev181743 doi: 10.1242/dev.181743 Published 28 June 2019

PREPRINT HIGHLIGHTS

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    The latest from the preLights community – June 2019
    Development 2019 146: p1301
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Development: 146 (13)
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