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November, 2019; 146 (21)

RESEARCH HIGHLIGHTS

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    PLXNA1 and PLXNA3 let GnRH neurons follow your nose
    Development 2019 146: e2101
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    A lineage tracing hat TRiCK
    Development 2019 146: e2102
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    Myosin's motor – behind the wheel in embryonic cytokinesis
    Development 2019 146: e2103

INTERVIEW

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    The people behind the papers – Daniel OsĂ³rio, Elaine Chan, Joana Saramago and Ana Carvalho
    Development 2019 146: dev185371 doi: 10.1242/dev.185371 Published 12 November 2019

OBITUARY

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    Suzanne Eaton (1959-2019)
    Frank JĂ¼licher
    Development 2019 146: dev185538 doi: 10.1242/dev.185538 Published 4 November 2019

    Summary: Frank JĂ¼licher looks back on the life of Suzanne Eaton and reflects on how her work on Drosophila tissue morphogenesis contributed to the fields of cell and developmental biology.

PRIMER

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    Model systems for regeneration: Hydra
    Matthias C. Vogg, Brigitte Galliot, Charisios D. Tsiairis
    Development 2019 146: dev177212 doi: 10.1242/dev.177212 Published 1 November 2019

    Summary: This Primer discusses Hydra as a model system for investigating regeneration, highlighting how the reactivation of developmental processes leads to whole-body regeneration after amputation and also after tissue dissociation and reaggregation of organoid-like structures.

REVIEW

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    Axo-glial interdependence in peripheral nerve development
    Robert Fledrich, Theresa Kungl, Klaus-Armin Nave, Ruth M. Stassart
    Development 2019 146: dev151704 doi: 10.1242/dev.151704 Published 12 November 2019

    Summary: This Review focuses on the specific interdependence of axons and Schwann cells that enables peripheral nerve development and maintenance.

STEM CELLS AND REGENERATION

  • Open Access
    N-cadherin stabilises neural identity by dampening anti-neural signals
    Karolina Punovuori, Rosa P. Migueles, Mattias Malaguti, Guillaume Blin, Kenneth G. Macleod, Neil O. Carragher, Tim Pieters, Frans van Roy, Marc P. Stemmler, Sally Lowell
    Development 2019 146: dev183269 doi: 10.1242/dev.183269 Published 8 November 2019

    Summary: As pluripotent cells undergo neural differentiation they swap E-cadherin for N-cadherin. This switch in adhesion molecules modulates signalling in order to facilitate the differentiation process.

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    CDK2 kinase activity is a regulator of male germ cell fate
    Priti Singh, Ravi K. Patel, Nathan Palmer, Jennifer K. Grenier, Darius Paduch, Philipp Kaldis, Andrew Grimson, John C. Schimenti
    Development 2019 146: dev180273 doi: 10.1242/dev.180273 Published 6 November 2019

    Summary: Although the cyclin-dependent kinase CDK2 is not necessary for spermatogonial function in mice, CDK2 hyperactivity delays establishment of the spermatogonial stem cells and prevents their differentiation.

RESEARCH REPORTS

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    PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons
    Roberto Oleari, Alessia Caramello, Sara Campinoti, Antonella Lettieri, Elena Ioannou, Alyssa Paganoni, Alessandro Fantin, Anna Cariboni, Christiana Ruhrberg
    Development 2019 146: dev176461 doi: 10.1242/dev.176461 Published 5 November 2019

    Highlighted Article: PLXNA1 and PLXNA3 convey the pathfinding of olfactory and vomeronasal axons as a prerequisite for neuroendocrine neurons to migrate into the hypothalamus and release gonadotropins into the circulation.

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    Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function
    Sri Teja Mullapudi, Giulia L. M. Boezio, Andrea Rossi, Michele Marass, Ryota L. Matsuoka, Hiroki Matsuda, Christian S. M. Helker, Yu Hsuan Carol Yang, Didier Y. R. Stainier
    Development 2019 146: dev173674 doi: 10.1242/dev.173674 Published 4 November 2019

    Summary: Expressing anti-angiogenic signals in the zebrafish pancreatic islet reveals distinct roles for the vasculature in tissue architecture and function.

RESEARCH ARTICLES

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    Dynamics of Spaetzle morphogen shuttling in the Drosophila embryo shapes gastrulation patterning
    Neta Rahimi, Inna Averbukh, Shari Carmon, Eyal D. Schejter, Naama Barkai, Ben-Zion Shilo
    Development 2019 146: dev181487 doi: 10.1242/dev.181487 Published 12 November 2019

    Summary: Live imaging of the early Drosophila embryo reveals the dynamics of an extracellular morphogen gradient that undergoes continuous refinement by ligand shuttling, generating a sharp morphogen peak that is essential for patterning gastrulation.

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    Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature
    Shigeru Okuhara, Anahid A. Birjandi, Hadeel Adel Al-Lami, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi, Guilherme M. Xavier, Karen J. Liu, Martyn T. Cobourne, Sachiko Iseki
    Development 2019 146: dev180075 doi: 10.1242/dev.180075 Published 12 November 2019

    Summary: Temporospatial sonic hedgehog signalling in neural crest-derived lingual mesenchyme is involved in arrangement of the lingual muscles through tenocyte differentiation.

  • Open Access
    Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans
    Daniel S. OsĂ³rio, Fung-Yi Chan, Joana Saramago, Joana Leite, Ana M. Silva, Ana F. Sobral, Reto Gassmann, Ana Xavier Carvalho
    Development 2019 146: dev179150 doi: 10.1242/dev.179150 Published 12 November 2019

    Highlighted Article: The motor activity of non-muscle myosin II is essential for cytokinesis and contributes to all stages of the process in C. elegans embryos.

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    Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans
    Orkan Ilbay, Victor Ambros
    Development 2019 146: dev183111 doi: 10.1242/dev.183111 Published 6 November 2019

    Summary: Inhibition of nuclear accumulation and microRNA-mediated repression of protein synthesis cooperate to confer the necessary precision and robustness to temporal downregulation of a transcription factor.

  • Open Access
    GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126
    Md. Riaj Mahamud, Xin Geng, Yen-Chun Ho, Boksik Cha, Yuenhee Kim, Jing Ma, Lijuan Chen, Greggory Myers, Sally Camper, Debbie Mustacich, Marlys Witte, Dongwon Choi, Young-Kwon Hong, Hong Chen, Gaurav Varshney, James Douglas Engel, Shusheng Wang, Tae-Hoon Kim, Kim-Chew Lim, R. Sathish Srinivasan
    Development 2019 146: dev184218 doi: 10.1242/dev.184218 Published 5 November 2019

    Summary: GATA2 and its target gene miR-126 are novel regulators of lymphatic endothelial cell junctions, which are important regulators of vascular morphogenesis.

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    Endocrine and local signaling interact to regulate spermatogenesis in zebrafish: follicle-stimulating hormone, retinoic acid and androgens
    Diego Crespo, Luiz H. C. Assis, Henk J. G. van de Kant, Sjors de Waard, Diego Safian, Moline S. Lemos, Jan Bogerd, RĂ¼diger W. Schulz
    Development 2019 146: dev178665 doi: 10.1242/dev.178665 Published 4 November 2019

    Summary: Retinoic acid is important for, and integrated into, the endocrine regulation of zebrafish spermatogenesis; however, in contrast to mammals, is not crucial for spermatogonia differentiation.

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    Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea
    Tomoko Tateya, Susumu Sakamoto, Fumiyoshi Ishidate, Tsuyoshi Hirashima, Itaru Imayoshi, Ryoichiro Kageyama
    Development 2019 146: dev177881 doi: 10.1242/dev.177881 Published 1 November 2019

    Summary: Time-lapse three-dimensional imaging is a powerful method to analyze spatiotemporal gene expression changes of individual cells in inner and outer hair cell fate control of embryonic cochlear epithelium.

TECHNIQUES AND RESOURCES

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    Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers
    Takashi Serizawa, Ayako Isotani, Takafumi Matsumura, Katsuyuki Nakanishi, Shigenori Nonaka, Shinsuke Shibata, Masahito Ikawa, Hideyuki Okano
    Development 2019 146: dev174938 doi: 10.1242/dev.174938 Published 4 November 2019

    Highlighted Article: We have developed a new transgenic technique for simultaneous labelling of all three germ layers in mice that overcomes the difficulties of conventional single-gene tracing systems in precision lineage tracing.

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Development: 146 (21)
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    Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes

    Daniel J. Barbosa, Vanessa Teixeira, Joana Duro, Ana X. Carvalho, Reto Gassmann
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    CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains

    Toshiya Kimura, Hiroko Saito, Miwa Kawasaki, Masatoshi Takeichi
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    Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

    Thomas J. Cahill, Xin Sun, Christophe Ravaud, Cristina Villa del Campo, Konstantinos Klaourakis, Irina-Elena Lupu, Allegra M. Lord, Cathy Browne, Sten Eirik W. Jacobsen, David R. Greaves, David G. Jackson, Sally A. Cowley, William James, Robin P. Choudhury, Joaquim Miguel Vieira, Paul R. Riley
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    C. elegans establishes germline versus soma by balancing inherited histone methylation

    Brandon S. Carpenter, Teresa W. Lee, Caroline F. Plott, Juan D. Rodriguez, Jovan S. Brockett, Dexter A. Myrick, David J. Katz
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    Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton

    Joanna Smeeton, Natasha Natarajan, Arati Naveen Kumar, Tetsuto Miyashita, Pranidhi Baddam, Peter Fabian, Daniel Graf, J. Gage Crump
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Kathryn Virginia Anderson (1952-2020)

Developmental geneticist Kathryn Anderson passed away at home on 30 November 2020. Tamara Caspary, a former postdoc and friend, remembers Kathryn and her remarkable contribution to developmental biology.


Zooming into 2021

In a new Editorial, Editor-in-Chief James Briscoe and Executive Editor Katherine Brown reflect on the triumphs and tribulations of the last 12 months, and look towards a hopefully calmer and more predictable year.


Read & Publish participation extends worldwide

Over 60 institutions in 12 countries are now participating in our Read & Publish initiative. Here, James Briscoe explains what this means for his institution, The Francis Crick Institute. Find out more and view our full list of participating institutions.


Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.


Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Sign up to join our next session:

10 February
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