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December, 2019; 146 (24)

RESEARCH HIGHLIGHTS

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    BNC1: at the heart of epicardial development
    Development 2019 146: e2401
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    Paf1C maintains neural crest progenitors
    Development 2019 146: e2402
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    Human endoderm development: the nEnd is only a beginning
    Development 2019 146: e2403

INTERVIEW

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    The people behind the papers – Madeleine Linneberg-Agerholm, Yan Fung Wong and Josh Brickman
    Development 2019 146: dev186635 doi: 10.1242/dev.186635 Published 16 December 2019

SPOTLIGHT

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    Wolpert's French Flag: what's the problem?
    James Sharpe
    Development 2019 146: dev185967 doi: 10.1242/dev.185967 Published 20 December 2019

    Summary: This Spotlight discusses how and why Wolpert introduced the French Flag metaphor into developmental biology, but how his original idea was probably oversimplified by the community.

REVIEW

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    Positional information and tissue scaling during development and regeneration
    Daniel Čapek, Patrick Müller
    Development 2019 146: dev177709 doi: 10.1242/dev.177709 Published 20 December 2019

    Summary: Tissue proportions can adjust to altered cell numbers. This Review discusses scaling mechanisms from a molecular and mathematical perspective.

HUMAN DEVELOPMENT

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    Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm
    Madeleine Linneberg-Agerholm, Yan Fung Wong, Jose Alejandro Romero Herrera, Rita S. Monteiro, Kathryn G. V. Anderson, Joshua M. Brickman
    Development 2019 146: dev180620 doi: 10.1242/dev.180620 Published 16 December 2019

    Highlighted Article: Exploiting naïve human embryonic stem cells, this study generates an in vitro model for primitive endoderm, its expansion, and demonstrates a conserved role for FGF/ERK signalling in its induction.

  • Open Access
    BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium
    Laure Gambardella, Sophie A. McManus, Victoria Moignard, Derya Sebukhan, Agathe Delaune, Simon Andrews, William G. Bernard, Maura A. Morrison, Paul R. Riley, Berthold Göttgens, Nicolas Gambardella Le Novère, Sanjay Sinha
    Development 2019 146: dev174441 doi: 10.1242/dev.174441 Published 13 December 2019

    Highlighted Article: Single cell analysis of human pluripotent stem cell-derived epicardium revealed that epicardial heterogeneity is regulated by the transcription factor BNC1 and separates the cells into two populations with different properties.

STEM CELLS AND REGENERATION

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    Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche
    Harleen Kaur, Shiv Kumar Sharma, Sudip Mandal, Lolitika Mandal
    Development 2019 146: dev178202 doi: 10.1242/dev.178202 Published 23 December 2019

    Summary: Lar limits insulin signaling to regulate the size and activity of the larval hematopoietic niche in Drosophila.

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    The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors
    Michael J. Jurynec, Xiaoying Bai, Brent W. Bisgrove, Haley Jackson, Alex Nechiporuk, Rebecca A. S. Palu, Hannah A. Grunwald, Yi-Chu Su, Kazuyuki Hoshijima, H. Joseph Yost, Leonard I. Zon, David Jonah Grunwald
    Development 2019 146: dev180133 doi: 10.1242/dev.180133 Published 16 December 2019

    Highlighted Article: Polymerase-associated factor 1 complex function is required to maintain the neural crest progenitor population in zebrafish.

RESEARCH ARTICLES

  • Open Access
    The histone demethylase KDM5 controls developmental timing in Drosophila by promoting prothoracic gland endocycles
    Coralie Drelon, Michael F. Rogers, Helen M. Belalcazar, Julie Secombe
    Development 2019 146: dev182568 doi: 10.1242/dev.182568 Published 20 December 2019

    Summary: Identification of KDM5 as a new transcriptional regulator of the MAPK signaling cascade provides insights into the molecular mechanisms governing the regulation of ecdysone production and developmental growth control.

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    PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants
    Ravindra S. Prajapati, Mark Hintze, Andrea Streit
    Development 2019 146: dev181107 doi: 10.1242/dev.181107 Published 16 December 2019

    Summary: PRDM1 mediates transcriptional activation of neural and sensory progenitor genes by recruiting histone demethylases such as Kdm4a to their promoters, but must then be repressed to maintain neural, neural crest and placode cell fates.

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    E3 ubiquitin ligase MDM2 acts through p53 to control respiratory progenitor cell number and lung size
    Pengfei Sui, Rongbo Li, Yan Zhang, Chunting Tan, Ankur Garg, Jamie M. Verheyden, Xin Sun
    Development 2019 146: dev179820 doi: 10.1242/dev.179820 Published 16 December 2019

    Summary: The MDM2-p53 axis determines lung progenitor cell number and subsequent organ size, but not airway patterning and cell differentiation.

  • Open Access
    A biphasic role of non-canonical Wnt16 signaling during early anterior-posterior patterning and morphogenesis of the sea urchin embryo
    Marina Martínez-Bartolomé, Ryan C. Range
    Development 2019 146: dev168799 doi: 10.1242/dev.168799 Published 16 December 2019

    Summary: Non-canonical Wnt16 signaling is essential for establishing the position of the early germ layer gene regulatory networks along the anterior-posterior axis, and activates molecular mechanisms necessary for gastrulation and mesenchyme morphogenesis.

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    The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis
    Shashi Kumar Suman, Csaba Daday, Teresa Ferraro, Thanh Vuong-Brender, Saurabh Tak, Sophie Quintin, François Robin, Frauke Gräter, Michel Labouesse
    Development 2019 146: dev183780 doi: 10.1242/dev.183780 Published 13 December 2019

    Summary: CRISPR-derived deletions reveal the roles of distinct domains from the hemidesmosome sprectraplakin VAB-10 in mechanotransduction during C. elegans morphogenesis.

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Development: 146 (24)
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  • Open Access

    PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors

    Li He, Jennifer Jones, Weiguo He, Bryan C. Bjork, Jiayu Wen, Qi Dai
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    Mechanosensory neuron regeneration in adult Drosophila

    Ismael Fernández-Hernández, Evan B. Marsh, Michael A. Bonaguidi
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    Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine

    Meghan Ferguson, Kristina Petkau, Minjeong Shin, Anthony Galenza, David Fast, Edan Foley
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    Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster

    M. Alessandra Vigano, Clara-Maria Ell, Manuela M. M. Kustermann, Gustavo Aguilar, Shinya Matsuda, Ning Zhao, Timothy J. Stasevich, Markus Affolter, George Pyrowolakis
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    Sox2-Evf2 lncRNA mechanisms of chromosome topological control in developing forebrain

    Ivelisse Cajigas, Abhijit Chakraborty, Madison Lynam, Kelsey R. Swyter, Monique Bastidas, Linden Collens, Hao Luo, Ferhat Ay, Jhumku D. Kohtz
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An interview with Swathi Arur

Swathi Arur joined the team at Development as an Academic Editor in 2020. Her lab uses multidisciplinary approaches to understand female germline development and fertility. We met with her over Zoom to hear more about her life, her career and her love for C. elegans.


Jim Wells and Hanna Mikkola join our team of Editors

We are pleased to welcome James (Jim) Wells and Hanna Mikkola to our team of Editors. Jim joins us a new Academic Editor, taking over from Gordan Keller, and Hanna joins our team of Associate Editors. Find out more about their research interests and areas of expertise.


New funding scheme supports sustainable events

As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.


Read & Publish participation continues to grow

“I’d heard of Read & Publish deals and knew that many universities, including mine, had signed up to them but I had not previously understood the benefits that these deals bring to authors who work at those universities.”

Professor Sally Lowell (University of Edinburgh) shares her experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 150 institutions in 15 countries and four library consortia taking part – find out more and view our full list of participating institutions.


Upcoming special issues

Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021

The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022

Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.


Development presents...

Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Here, Brandon Carpenter talks about how inherited histone methylation defines the germline versus soma decision in C. elegans. 

Sign up to join our next session:

10 March
Time: TBC
Chaired by: Thomas Lecuit

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