A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart by Honkoop et al.

Heart regeneration: Cardiomyocytes need to undergo a metabolic switch in order to re-enter the cell cycle.

Selected by Andreas van Impel. Read the preLight here

A direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila by Uyehara & McKay

Here, there, everywhere: extensive and dynamic genome binding by a steroid hormone receptor highlights the interconnection between systemic and local cues for organ development.

Selected by Natalie Dye. Read the preLight here

Single cell RNA-Seq reveals distinct stem cell populations that drive sensory hair cell regeneration in response to loss of Fgf and Notch signaling by Lush et al.

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Distinct progenitor populations mediate regeneration in the zebrafish lateral line by Thomas & Raible

How to keep an organ ticking? Two preprints delve into the molecular and functional heterogeneity within the progenitor cell populations that maintains the zebrafish sensory hair cells, and forms the basis of hair cell regeneration.

Selected by Rudra Nayan Das. Read the preLight here

Reconstruction of the global neural crest gene regulatory network in vivo by Williams et al.

How to build a vertebrate neural crest: reconstructing neural crest gene regulatory networks in vivo.

Selected by Hannah Brunsdon. Read the preLight here

Lineage tracing on transcriptional landscapes links state to fate during differentiation by Weinreb et al.

Lineage-traced scRNA-seq reveals that inheritable fate restriction occurring early in hematopoiesis is not detected computationally from the progenitor transcriptome.

Selected by Yen-Chung Chen. Read the preLight here

Charting a tissue from single-cell transcriptomes by Nitzan et al.

A new exciting approach promises to resuscitate the spatial context of cells from scRNAseq without marker genes.

Selected by Irepan Salvador-Martinez. Read the preLight here

A conserved MFS orchestrates a subset of O-glycosylation to facilitate macrophage dissemination and tissue invasion by Valoskova et al.

Minerva instructs Drosophila embryonic macrophages to push the boundaries of tissue invasion by initiating a developmentally controlled program of glycosylation.

Selected by Giuliana Clemente. Read the preLight here

High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue-specificity by Mattioli et al.

What core promoter sequence features are important for gene activity? Mattioli et al. uncover an important role of overlapping motifs.

Selected by Clarice Hong. Read the preLight here

Actomyosin-II facilitates long-range retrograde transport of large cargoes by controlling axonal radial contractility by Wang et al.

Be flexible or die: how neuronal axons transport large cargos.

Selected by Ivana Viktorianova. Read the preLight here

Distinct ROPGEFs successively drive polarization and outgrowth of root hairs by Denninger et al.

From root hair site initiation to tip-guided outgrowth: a timeline of ROP-GEF activities.

Selected by Marc Somssich. Read the preLight here

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts by Chang et al.

A new role for the MRN complex - protecting our genome from R-loops via recruitment and activation of the Fanconi Anemia pathway.

Selected by Katie Weiner. Read the preLight here

Embryo geometry drives formation of robust signaling gradients through receptor localization by Zhang et al.

Polarity, geometry and patterning: an in vivo role for BMP receptor basolateral polarization and tissue geometry in robust embryonic patterning.

Selected by Diana Pinheiro. Read the preLight here

Regulation of modulatory cell activity across olfactory structures in Drosophila melanogaster by Zhang et al.

Multifaceted cells in the brain – Upon receiving a stimulus, a huge serotonergic neuron can simultaneously provide different outputs at its different target-sites.

Selected by Rudra Nayan Das. Read the preLight here

Force inference predicts local and tissue-scale stress patterns in epithelia by Kong et al.

How to probe tissue mechanics without performing an invasive experiment? Kong et al. discuss and validate the force inference methodology.

Selected by Sundar Naganathan. Read the preLight here

Atlas of Subcellular RNA Localization Revealed by APEX-seq Furqan by Fazal et al.

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Proximity RNA labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules by Padròn et al.

APEX-Seq: A novel method to study RNA localisation reveals the spatial organisation of the transcriptome.

Selected by Christian Bates. Read the preLight here

Functional characterization of Arabidopsis ARGONAUTE 3 in reproductive tissue by Jullien et al.

Argonaute 3 facilitates posttranscriptional gene silencing in Arabidopsis female reproductive tissues.

Selected by Chandra Shekhar Misra. Read the preLight here

Tracking the popularity and outcomes of all bioRxiv preprints by Abdill & Blekhman

What makes preprints popular? preLighters respond to a meta-analysis of bioRxiv preprints.

Read the preLight here