RESEARCH HIGHLIGHTS
INTERVIEWS
SPOTLIGHT
- Unravelling spiral cleavage
Summary: Spiral cleavage is one of the most under-investigated, yet widespread developmental strategies in animals: a powerful system for exploring fundamental questions in evolutionary developmental biology.
CORRESPONDENCE
REVIEWS
- X chromosome inactivation in human development
Summary: This Review discusses our current knowledge of how X chromosome inactivation, an important model for epigenetic gene regulation, is initiated and controlled during early human embryo development.
- Parallels between wound healing, epimorphic regeneration and solid tumors
Summary: Although regeneration and cancer retain certain core differences as research models, emerging studies could allow us to bridge the biological mechanisms found in both and tackle important questions using a unified approach.
STEM CELLS AND REGENERATION
- Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain
Summary: A combination of lineage tracing and single cell sequencing identifies specific markers and functional subpopulations of adult newborn neurons in the zebrafish forebrain.
- Dual role of Jam3b in early hematopoietic and vascular development
Summary: A cell adhesion molecule, Jam3b, regulates both hematopoietic and vascular development via two independent signaling pathways in the zebrafish embryo.
- Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation
Summary: Analysis and quantification of chromatin accessibility and 5-hydroxymethylcytosine reveals cis-regulatory dynamics and associated transcription factors involved in intestinal stem cell differentiation.
RESEARCH ARTICLES
- Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression
Highlighted Article: Cilia movement and its induced asymmetric Hh signalling are the two key regulators for the establishment of amphioxus left-right asymmetry, likely representing an evolutionarily conserved mechanism in deuterostomes.
- Dosage-dependent requirements of Magoh for cortical interneuron generation and survival
Highlighted Article: Genetics, live imaging and genomics demonstrate that the RNA-binding protein Magoh, which controls progenitor mitosis, interneuron generation and survival, is required in a dosage-dependent manner for interneuron development.
- Neural crest cells bulldoze through the microenvironment using Aquaporin 1 to stabilize filopodia
Highlighted Article: Neural crest cells migrate through dense extracellular matrix and mesoderm towards specific embryonic targets. We have discovered that AQP-1, a water channel, affects cell speed, filopodia stability and ECM degradation.
- Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in C. elegans
Highlighted Article: Investigations of cytokinesis reveal reproducible patterns during early embryonic development and specialized cytokinesis during epithelial polarization at morphogenesis in Caenorhabditis elegans.
- The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis
Summary: Discovery of novel PAX-SIX-EYA-DACH and GATA network interactions in Drosophila hematopoiesis reveal that human SIX proteins can associate with GATA1, stimulate GATA1-dependent transcription and enhance human erythropoiesis in vitro.
- A developmental gene regulatory network for C. elegans anchor cell invasion
Summary: Transcription factors that independently regulate specification of the C. elegans anchor cell function together in a gene regulatory network encompassing cell cycle-dependent and -independent sub-circuits that coordinate basement membrane invasion.