RESEARCH HIGHLIGHTS
INTERVIEWS
SPOTLIGHT
- Unravelling spiral cleavage
Summary: Spiral cleavage is one of the most under-investigated, yet widespread developmental strategies in animals: a powerful system for exploring fundamental questions in evolutionary developmental biology.
CORRESPONDENCE
REVIEWS
- X chromosome inactivation in human development
Summary: This Review discusses our current knowledge of how X chromosome inactivation, an important model for epigenetic gene regulation, is initiated and controlled during early human embryo development.
- Parallels between wound healing, epimorphic regeneration and solid tumors
Summary: Although regeneration and cancer retain certain core differences as research models, emerging studies could allow us to bridge the biological mechanisms found in both and tackle important questions using a unified approach.
STEM CELLS AND REGENERATION
- Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain
Summary: A combination of lineage tracing and single cell sequencing identifies specific markers and functional subpopulations of adult newborn neurons in the zebrafish forebrain.
- Dual role of Jam3b in early hematopoietic and vascular development
Summary: A cell adhesion molecule, Jam3b, regulates both hematopoietic and vascular development via two independent signaling pathways in the zebrafish embryo.
- Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation
Summary: Analysis and quantification of chromatin accessibility and 5-hydroxymethylcytosine reveals cis-regulatory dynamics and associated transcription factors involved in intestinal stem cell differentiation.
RESEARCH ARTICLES
- Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression
Highlighted Article: Cilia movement and its induced asymmetric Hh signalling are the two key regulators for the establishment of amphioxus left-right asymmetry, likely representing an evolutionarily conserved mechanism in deuterostomes.
- Dosage-dependent requirements of Magoh for cortical interneuron generation and survival
Highlighted Article: Genetics, live imaging and genomics demonstrate that the RNA-binding protein Magoh, which controls progenitor mitosis, interneuron generation and survival, is required in a dosage-dependent manner for interneuron development.
- Neural crest cells bulldoze through the microenvironment using Aquaporin 1 to stabilize filopodia
Highlighted Article: Neural crest cells migrate through dense extracellular matrix and mesoderm towards specific embryonic targets. We have discovered that AQP-1, a water channel, affects cell speed, filopodia stability and ECM degradation.
- Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in C. elegans
Highlighted Article: Investigations of cytokinesis reveal reproducible patterns during early embryonic development and specialized cytokinesis during epithelial polarization at morphogenesis in Caenorhabditis elegans.
- The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis
Summary: Discovery of novel PAX-SIX-EYA-DACH and GATA network interactions in Drosophila hematopoiesis reveal that human SIX proteins can associate with GATA1, stimulate GATA1-dependent transcription and enhance human erythropoiesis in vitro.
- A developmental gene regulatory network for C. elegans anchor cell invasion
Summary: Transcription factors that independently regulate specification of the C. elegans anchor cell function together in a gene regulatory network encompassing cell cycle-dependent and -independent sub-circuits that coordinate basement membrane invasion.
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2019 on the Node
Read about the most-read posts, scientists on tour and a glimpse into what to look our for in 2020.
Interview – Madeleine Linneberg-Agerholm, Yan Fung Wong and Josh Brickman
Three Copenhagen-based researchers discuss their new paper, which exploits naïve human embryonic stem cells to generate in vitro models for the extra-embryonic endoderm.
As 2020 gets well and truly underway, join us as we look back at seven things that shaped preLights in 2019. From launching preLists to getting nominated for an award, it was an exciting year!
Publishing peer review reports
To continue working towards transparency around the editorial process, Development now publishes a ‘Peer review history file’ alongside published papers. Read more about the policy and see the reports for yourself in one the first papers to publish the reports (under the ‘Info & metrics’ tab).