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REVIEW
From head to tail: regionalization of the neural crest
Manuel Rocha, Anastasia Beiriger, Elaine E. Kushkowski, Tetsuto Miyashita, Noor Singh, Vishruth Venkataraman, Victoria E. Prince
Development 2020 147: dev193888 doi: 10.1242/dev.193888 Published 26 October 2020
Manuel Rocha
1Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, IL 60637, USA
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Anastasia Beiriger
2Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
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Elaine E. Kushkowski
1Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, IL 60637, USA
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Tetsuto Miyashita
2Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
3Canadian Museum of Nature, Ottawa, ON K1P 6P4, Canada
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Noor Singh
2Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
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Vishruth Venkataraman
2Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
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Victoria E. Prince
1Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, IL 60637, USA
2Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
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ABSTRACT

The neural crest is regionalized along the anteroposterior axis, as demonstrated by foundational lineage-tracing experiments that showed the restricted developmental potential of neural crest cells originating in the head. Here, we explore how recent studies of experimental embryology, genetic circuits and stem cell differentiation have shaped our understanding of the mechanisms that establish axial-specific populations of neural crest cells. Additionally, we evaluate how comparative, anatomical and genomic approaches have informed our current understanding of the evolution of the neural crest and its contribution to the vertebrate body.

Footnotes

  • Competing interests

    The authors declare no competing or financial interests.

  • Funding

    Related work in the Prince lab was funded by a National Science Foundation award (1528911) and by the Chicago Biomedical Consortium with support from the Searle Funds at Chicago Community Trust (C-070 to V.E.P. and Ankur Saxena). M.R. and A.B. were supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (T32HD055164). This material is additionally based upon research supported by a grant from the NICHD (F31HD097957 to M.R.) and by the National Science Foundation Graduate Research Fellowship Program (DGE-1144082 to A.B.). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Institutes of Health or the National Science Foundation. Deposited in PMC for release after 12 months.

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Keywords

  • Neural crest
  • Ectomesenchyme
  • Stem cells
  • Gene regulatory networks
  • Patterning

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REVIEW
From head to tail: regionalization of the neural crest
Manuel Rocha, Anastasia Beiriger, Elaine E. Kushkowski, Tetsuto Miyashita, Noor Singh, Vishruth Venkataraman, Victoria E. Prince
Development 2020 147: dev193888 doi: 10.1242/dev.193888 Published 26 October 2020
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REVIEW
From head to tail: regionalization of the neural crest
Manuel Rocha, Anastasia Beiriger, Elaine E. Kushkowski, Tetsuto Miyashita, Noor Singh, Vishruth Venkataraman, Victoria E. Prince
Development 2020 147: dev193888 doi: 10.1242/dev.193888 Published 26 October 2020

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  • Article
    • ABSTRACT
    • Introduction
    • Axial differences in neural crest differentiation potential
    • Axial-specific gene regulatory networks
    • Lessons from stem cells
    • The evolution of neural crest regionalization
    • Conclusions and perspectives
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