ABSTRACT
The heart is an essential organ with a fascinating developmental biology. It is also one of the organs that is most often affected in human disease, either during development or in postnatal life. Over the last few decades, insights into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart, exemplifying the importance of understanding the mechanistic underpinnings that lead to the development of an organ.
Footnotes
Competing interests
B.G.B. is a co-founder of Tenaya Therapeutics, which aims to use developmentally important factors as therapies for heart failure.
Funding
B.G.B. was funded by the National Heart, Lung, and Blood Institute (R01 HL114948, UM1 HL098179) and the Gladstone Institutes. Deposited in PMC for release after 12 months.
- Received June 18, 2020.
- Accepted September 28, 2020.
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