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PRIMER
The developing heart: from The Wizard of Oz to congenital heart disease
Benoit G. Bruneau
Development 2020 147: dev194233 doi: 10.1242/dev.194233 Published 21 October 2020
Benoit G. Bruneau
1Gladstone Institutes, San Francisco, CA 94158, USA
2Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA
3Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
4Department of Pediatrics, University of California, San Francisco, CA 94143, USA
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  • For correspondence: benoit.bruneau@gladstone.ucsf.edu
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ABSTRACT

The heart is an essential organ with a fascinating developmental biology. It is also one of the organs that is most often affected in human disease, either during development or in postnatal life. Over the last few decades, insights into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart, exemplifying the importance of understanding the mechanistic underpinnings that lead to the development of an organ.

Footnotes

  • Competing interests

    B.G.B. is a co-founder of Tenaya Therapeutics, which aims to use developmentally important factors as therapies for heart failure.

  • Funding

    B.G.B. was funded by the National Heart, Lung, and Blood Institute (R01 HL114948, UM1 HL098179) and the Gladstone Institutes. Deposited in PMC for release after 12 months.

  • Received June 18, 2020.
  • Accepted September 28, 2020.
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Keywords

  • Heart development
  • Gene regulation
  • Congenital heart disease
  • Regeneration

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PRIMER
The developing heart: from The Wizard of Oz to congenital heart disease
Benoit G. Bruneau
Development 2020 147: dev194233 doi: 10.1242/dev.194233 Published 21 October 2020
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PRIMER
The developing heart: from The Wizard of Oz to congenital heart disease
Benoit G. Bruneau
Development 2020 147: dev194233 doi: 10.1242/dev.194233 Published 21 October 2020

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Article navigation

  • Top
  • Article
    • ABSTRACT
    • Introduction
    • Tinman and the heart
    • From Tinman to congenital heart disease
    • Other transcription factors and CHD
    • Chromatin factors in heart development and CHD
    • Back to the issue of regeneration
    • Concluding remarks
    • Footnotes
    • References
  • Figures & tables
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